LOCUS BC028919 1290 bp mRNA linear HUM 06-APR-2004
DEFINITION Homo sapiens transducer of ERBB2, 2, mRNA (cDNA clone MGC:24875
IMAGE:4940977), complete cds.
ACCESSION BC028919
VERSION BC028919.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1290)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1290)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (01-MAY-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: David N. Louis, M.D.
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Baylor College of Medicine Human Genome
Sequencing Center
Center code: BCM-HGSC
Web site: http://www.hgsc.bcm.tmc.edu/cdna/
Contact: amg@bcm.tmc.edu
Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
A.N., Gibbs, R.A.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 29 Row: p Column: 22
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 7706738.
FEATURES Location/Qualifiers
source 1..1290
/db_xref="H-InvDB:HIT000259011"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:24875 IMAGE:4940977"
/tissue_type="Brain, anaplastic oligodendroglioma with
1p/19q loss"
/clone_lib="NCI_CGAP_Brn67"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..1290
/gene="TOB2"
/gene_synonym="bK223H9"
/gene_synonym="bK223H9.1.mRNA"
/gene_synonym="KIAA1663"
/gene_synonym="TOB4"
/gene_synonym="TOBL"
/gene_synonym="TROB2"
/db_xref="GeneID:10766"
/db_xref="MIM:607396"
CDS 457..1209
/gene="TOB2"
/gene_synonym="bK223H9"
/gene_synonym="bK223H9.1.mRNA"
/gene_synonym="KIAA1663"
/gene_synonym="TOB4"
/gene_synonym="TOBL"
/gene_synonym="TROB2"
/codon_start=1
/product="TOB2 protein"
/protein_id="AAH28919.1"
/db_xref="GeneID:10766"
/db_xref="MIM:607396"
/translation="MQLEIKVALNFIISYLYNKLPRRRADLFGEELERLLKKKYEGHW
YPEKPLKGSGFRCVHIGEMVDPVVELAAKRSGLAVEDVRANVPEELSVWIDPFEVSYQ
IGEKGAVKVLYLDDSEGCGAPELDKEIKSSFNPDAQVFVPIGSQDSSLSNSPSPSFGQ
SPSPTFIPRSAQPITFTTASFAATKFGSTKMKKGGGAASGGGVASSGAGGQQPPQQPR
MARSPTNSLLKHKSLSLSMHSLNFITDYNHDQ"
misc_feature 457..888
/gene="TOB2"
/gene_synonym="bK223H9"
/gene_synonym="bK223H9.1.mRNA"
/gene_synonym="KIAA1663"
/gene_synonym="TOB4"
/gene_synonym="TOBL"
/gene_synonym="TROB2"
/note="Anti_proliferat; Region: BTG1 family. A novel
family of anti-proliferative proteins"
/db_xref="CDD:pfam01211"
BASE COUNT 306 a 405 c 363 g 216 t
ORIGIN
1 gcgggttgtt ggctgaggca agccgtggct cgggcgacgc ggggccagga gggcaggacc
61 gtctgccggc gacagcccat accgtctgcc gttgcgcgac acgaaccacc ctccgatccg
121 ccatccccgc gtcgtcgccg ctagtccgcc cgcccgccct cgggcccccc gctgccgagc
181 ccgacctcct aagagctgaa agaaattatt gagagtcata gtccatagcc ccctgcttcg
241 tcccccaacc ctcaacgacg aaaaggactt cggtcccctg gcccggcgac gcccgggaag
301 gaaaggagag cgacctccgc cccgcgctca ggccaccctg gagggagaag ccgccccgcg
361 accggtagag cgccccgccg ccgcggagac ccgaagccgc ctggagccca aggctgtaca
421 cgtgccctgt gctgattctc tgcctaggaa aggaccatgc agctagagat caaagtggcc
481 ctgaacttca tcatctccta cttgtacaac aagctgcccc ggcgccgggc agacctgttt
541 ggggaggagc tagagcggct tttgaaaaag aaatatgaag gccactggta ccctgagaag
601 ccactgaaag gctctggctt ccgctgtgtt cacattgggg agatggtgga ccccgtggtg
661 gagctggccg ccaagcggag tggcctggcg gtggaagatg tgcgggccaa tgtgcctgag
721 gagctgagtg tctggattga tccctttgag gtgtcctacc agattggtga gaagggagct
781 gtgaaagtgc tgtacctgga tgacagtgag ggttgcggtg ccccagagct ggacaaggag
841 atcaagagca gcttcaaccc tgacgcccag gtgttcgtgc ccattggcag ccaggacagc
901 tccctgtcca actccccatc gccatccttt ggccagtcac ccagccctac cttcattccc
961 cgctccgctc agcccatcac cttcaccacc gcctccttcg ctgccaccaa atttggctcc
1021 actaagatga agaagggggg cggggcagca agtggtgggg gtgtagccag cagtggggcg
1081 ggtggccagc agccaccaca gcagcctcgc atggcccgct cacccaccaa cagcctgctg
1141 aagcacaaga gcctctctct gtctatgcat tcactgaact tcatcacgga ctacaaccac
1201 gaccaatgat atgaaaaacc atcgttgtat ttcaactaca agaacaaaaa aaaaaaaaaa
1261 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//