LOCUS BC028425 3568 bp mRNA linear HUM 19-JUN-2006
DEFINITION Homo sapiens megalencephalic leukoencephalopathy with subcortical
cysts 1, mRNA (cDNA clone MGC:34016 IMAGE:4817175), complete cds.
ACCESSION BC028425
VERSION BC028425.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3568)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3568)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (23-APR-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Aug 25, 2003 this sequence version replaced BC028425.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Miklos Palkovits, M.D., Ph.D.
cDNA Library Preparation: Michael J. Brownstein (NHGRI) & Shiraki
Toshiyuki and Piero Carninci (RIKEN)
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Institute for Systems Biology
http://www.systemsbiology.org
contact: amadan@systemsbiology.org
Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha
Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 46 Row: f Column: 7
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 21237731.
FEATURES Location/Qualifiers
source 1..3568
/db_xref="H-InvDB:HIT000040565"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:34016 IMAGE:4817175"
/tissue_type="Brain, hippocampus"
/clone_lib="NIH_MGC_95"
/lab_host="DH10B"
/note="Vector: pBluescriptR"
gene 1..3568
/gene="MLC1"
/gene_synonym="KIAA0027"
/gene_synonym="LVM"
/gene_synonym="MLC"
/gene_synonym="VL"
/db_xref="GeneID:23209"
/db_xref="HGNC:HGNC:17082"
/db_xref="MIM:605908"
CDS 234..1367
/gene="MLC1"
/gene_synonym="KIAA0027"
/gene_synonym="LVM"
/gene_synonym="MLC"
/gene_synonym="VL"
/codon_start=1
/product="megalencephalic leukoencephalopathy with
subcortical cysts 1"
/protein_id="AAH28425.1"
/db_xref="GeneID:23209"
/db_xref="HGNC:HGNC:17082"
/db_xref="MIM:605908"
/translation="MTQEPFREELAYDRMPTLERGRQDHASYAPDAKPSDLQLSKRLP
PCFSHKTWVFSVLMGSCLLVTSGFSLYLGNVFPAEMDYLRCAAGSCIPSAIVSFTVSR
RNANVIPNFQILFVSTFAVTTTCLIWFGCKLVLNPSAININFNLILLLLLELLMAATV
IIAARSSEEDCKKKKGSMSDSANILDEVPFPARVLKSYSVVEVIAGISAVLGGIIALN
VDDSVSGPHLSVTFFWILVACFPSAIASHVAAECPSKCLVEVLIAISSLTSPLLFTAS
GYLSFSIMRIVEMFKDYPPAIKPSYDVLLLLLLLVLLLQAGLNTGTAIQCVRFKVSAR
LQGASWDTQNGPQERLAGEVARSPLKEFDKEKAWRAVVVQMAQ"
BASE COUNT 705 a 1048 c 1013 g 802 t
ORIGIN
1 gtgatctctc gtttagctac caattggagc agtttaacgt gcttgagtcc ccggcgtgat
61 gtgttcatgg acgaagttgc cgatggatgt tgtcaggtgt tgcacctgga gggcccagat
121 ggatcaatga ggcatttaaa gtgtagaatc tcaccctgaa cccagactat tcagataaag
181 aactggtgac acgtggctgt acattcagca cagctgtggt gtccccaagt gccatgaccc
241 aggagccatt cagagaggag ctggcctatg accggatgcc cacgctggag cggggccggc
301 aagaccacgc cagctatgcc ccagacgcga agccgagcga cctgcagctg tcgaagagac
361 tgcccccctg cttcagccac aagacgtggg tcttctctgt gctgatgggg agctgcctcc
421 tggtgacctc ggggttttcg ctgtacctgg ggaacgtgtt cccggctgag atggattact
481 tgcgctgtgc tgcaggctct tgcatcccct cggcaattgt gagcttcacc gtctccagga
541 ggaacgccaa tgtgattccc aactttcaga tattgtttgt ttccacgttt gctgtgacca
601 ctacgtgttt aatttggttt ggatgcaaac tagtcctgaa cccatcagca ataaacatca
661 acttcaacct catcctgctg ctcctgctgg agctgctcat ggcggccacg gtgatcatcg
721 ctgcacggtc cagcgaggag gactgcaaga aaaagaaggg ctccatgtct gacagcgcca
781 acattctgga cgaagtgcca tttcctgctc gggtcctgaa atcttactca gtcgtcgagg
841 taatcgcagg catctctgcc gtcctcgggg ggatcattgc cctgaacgtg gatgactcag
901 tttcaggccc acacctctca gtgacgttct tttggatcct agtggcctgc tttccaagtg
961 ccattgccag tcatgtggca gcagagtgtc ccagcaagtg tctggtggag gtcctgattg
1021 ccataagcag cctcacgtct ccgctgctgt tcacagcctc tggatatctg tcattcagca
1081 tcatgagaat cgtggagatg tttaaggatt acccgccagc cataaaacca tcctacgatg
1141 tgctgctgct gctgctgctg ctagtgctcc tgctgcaggc cggcctcaac acgggcaccg
1201 ccatccagtg cgtgcgcttc aaggtcagtg caaggctgca gggtgcatcc tgggacaccc
1261 agaacggccc gcaggagcgc ctggctgggg aggtggccag gagccccctg aaggagttcg
1321 acaaggagaa agcctggaga gccgtcgtgg tgcaaatggc ccagtgaccc ccagacgcgg
1381 aaaccgggtg gcagcgccca gcctggcccc aagcatggaa acgcacaacc cctaatcgcc
1441 ctgagctact gcttctaaca cctcttttcc cttgtgtgag ggcaaaccag gctgcaggtg
1501 gggttttcac ttcctagggt agtttaattt taaaataggc caatgttggc tagtctgtgc
1561 ctcagtgaga tcagtcagct ccgagtggct cccgtgtcgt aacagcagga gcatggccgc
1621 aacttcccag gccgaggaag ggcccccggc tcggcctctt gagagcccca cccctgaact
1681 ggccccagct cctcttcctg cctctctcat ggcttgggct ggagtgggct ctctggacct
1741 gaccagactg tgggtccctg cgtctcctgc ccactctgac cgggcttcct ccctccacgc
1801 ttagggtctg tcccgggtac tcagtcagcc cagtgggatc ttacccactt ccctgcaagg
1861 tgcacctgcc ccaggctcag gctgcccagc ggctcttcct ggacagtgag agcagggctg
1921 ggcgcctctg tcctggcccg ggagccgcag gggcccctcc tccagagcct gggcgcaagc
1981 gacacaggct gccgctgctc tcccaggtga aatccacacc agtccacgcc gggtcgcctg
2041 ccctgtctcc ctacttagac ccagtcattc tagagggatc caccgccaca ctggccggcc
2101 cacgtcctgg gtgctgtcat gcccagcttg gagtgccacg tggccgctgc ccacgtcccg
2161 ggcactgtca tgcccagctt ggagtgccac atggccgctg cccacgtccc gggcactgtc
2221 atgcccagct tggagtgcca cgtggccgct gctgtgacag gcagtgttct tgggggtggg
2281 gctgcatcca aggctttgta aaccggctgg accacgtctc cctggcccaa gtgaccgggg
2341 gaagctgagc ccctccctcc tgtgtttgct cccattactc aaaatgcagg acagatcagg
2401 tcagagccca ggaattctca caggttcacc cagcgccctc tacctcctag caagtacttt
2461 gtcttgatcc tcactgagaa ggccccaggg cagtggtctt ctccatctcc gctgttttgg
2521 ggtcttaggg tacagcccag gcggtcactg cccacctgcc aggctgcagg gacagttggg
2581 tgtgagaata acactggctt tgggtagtgc catggccagg agtgggtttc cctgcgtctc
2641 ctcgtcccga gggcgcctgg gtcctcccag ctgacggcag taaatccaca gtgagttggg
2701 gcgactgtga aactggaatg ctgttacttt gataattact ttccagcagg tgttttcctt
2761 cacaatggtt ttgtttcttt ccttctgatc tgagaagaca tgaacgtttt ctcttcaccg
2821 ccgtggggtg tattgactgg tcccccatgg gctgctggaa aggcccggag atgcatctgt
2881 ggcctggggc catcaagatc aaagaaccag gaggcctggg agatgcagct ggatggggcg
2941 gcctgcagac cctgccaggg ggtttgagga ccctcccagg tttcccactg cggaacagga
3001 gtgactctgg ctgccaagat accttcatgg tgttcatgac aagtggaatc attattttca
3061 accattgaag ggggatgcag gcaagacacc ttcccagctg ctcctagagg ggacaagcca
3121 ggccctctct gcagtcctcg gcagctccgg aaggacacag tcaggggccg ggcaaacact
3181 ttggccacag ccccaaacaa gcgccaccgt gggagaggag aggctgctgt cactggtacc
3241 ggatgcagac cccaccctgt ctgcaggcca cccccacctc cctgcagctt tgaggctggc
3301 ggggtctgct cctgggaatg gggtgggagc cacagggacg acccggggcg ggctgatgtc
3361 ttcttggggg cagaccagag agctcaagtt tcagagtcag aattaggcac ttggagcgtt
3421 tttgctggct tgcactttct tattttctta ttttagagcg cttaaaaaat ccggaaaaat
3481 ggggtttaaa agaactgtct ctttcagtct acatttttgt ttaatacgct tgagcaataa
3541 acgctgactt ccaaaaaaaa aaaaaaaa
//