LOCUS BC027179 1452 bp mRNA linear HUM 06-OCT-2003
DEFINITION Homo sapiens tyrosinase (oculocutaneous albinism IA), mRNA (cDNA
clone MGC:9191 IMAGE:3923096), complete cds.
ACCESSION BC027179
VERSION BC027179.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1452)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1452)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (04-APR-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC/DCTD/DTP
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Baylor College of Medicine Human Genome
Sequencing Center
Center code: BCM-HGSC
Web site: http://www.hgsc.bcm.tmc.edu/cdna/
Contact: amg@bcm.tmc.edu
Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
A.N., Gibbs, R.A.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 26 Row: d Column: 20
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 24475623.
FEATURES Location/Qualifiers
source 1..1452
/db_xref="H-InvDB:HIT000040247"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:9191 IMAGE:3923096"
/tissue_type="Skin, melanotic melanoma."
/clone_lib="NIH_MGC_72"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..1452
/gene="TYR"
/gene_synonym="OCA1A"
/gene_synonym="OCAIA"
/db_xref="GeneID:7299"
/db_xref="MIM:606933"
CDS 62..1195
/gene="TYR"
/gene_synonym="OCA1A"
/gene_synonym="OCAIA"
/codon_start=1
/product="TYR protein"
/protein_id="AAH27179.1"
/db_xref="GeneID:7299"
/db_xref="MIM:606933"
/translation="MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRS
PCGQLSGRGSCQNILLSNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGN
CKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMK
NGSTPMFNDINIYDLFVWMHYYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRW
EQEIQKLTGDENFTIPYWDWRDAEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVC
SRLEEYNSHQSLCNGTPEGPLRRNPGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDK
AANFSFRNTLEEMGFLHVGWAGLKLLTSRDPPPWPPKMLGLQA"
misc_feature 392..1096
/gene="TYR"
/gene_synonym="OCA1A"
/gene_synonym="OCAIA"
/note="tyrosinase; Region: Common central domain of
tyrosinase. This family also contains polyphenol oxidases
and some hemocyanins. Binds two copper ions via two sets
of three histidines. This family is related to pfam00372"
/db_xref="CDD:pfam00264"
BASE COUNT 401 a 331 c 317 g 403 t
ORIGIN
1 aagagaaatc tgtgactcca attagccagt tcctgcagac cttgtgagga ctagaggaag
61 aatgctcctg gctgttttgt actgcctgct gtggagtttc cagacctccg ctggccattt
121 ccctagagcc tgtgtctcct ctaagaacct gatggagaag gaatgctgtc caccgtggag
181 cggggacagg agtccctgtg gccagctttc aggcagaggt tcctgtcaga atatccttct
241 gtccaatgca ccacttgggc ctcaatttcc cttcacaggg gtggatgacc gggagtcgtg
301 gccttccgtc ttttataata ggacctgcca gtgctctggc aacttcatgg gattcaactg
361 tggaaactgc aagtttggct tttggggacc aaactgcaca gagagacgac tcttggtgag
421 aagaaacatc ttcgatttga gtgccccaga gaaggacaaa ttttttgcct acctcacttt
481 agcaaagcat accatcagct cagactatgt catccccata gggacctatg gccaaatgaa
541 aaatggatca acacccatgt ttaacgacat caatatttat gacctctttg tctggatgca
601 ttattatgtg tcaatggatg cactgcttgg gggatctgaa atctggagag acattgattt
661 tgcccatgaa gcaccagctt ttctgccttg gcatagactc ttcttgttgc ggtgggaaca
721 agaaatccag aagctgacag gagatgaaaa cttcactatt ccatattggg actggcggga
781 tgcagaaaag tgtgacattt gcacagatga gtacatggga ggtcagcacc ccacaaatcc
841 taacttactc agcccagcat cattcttctc ctcttggcag attgtctgta gccgattgga
901 ggagtacaac agccatcagt ctttatgcaa tggaacgccc gagggacctt tacggcgtaa
961 tcctggaaac catgacaaat ccagaacccc aaggctcccc tcttcagctg atgtagaatt
1021 ttgcctgagt ttgacccaat atgaatctgg ttccatggat aaagctgcca atttcagctt
1081 tagaaataca ctggaagaga tgggatttct ccatgttggc tgggctggtc tcaaactcct
1141 gacctcaaga gatccaccac cttggcctcc caaaatgctg ggattacagg cttgagccac
1201 cacacctggc ctaacttcaa ggtatcaaag acaaattaac aatgtctgat gcatacatag
1261 gactgctttg taatcttcta cactaatgat ttgtactatt ttggtttcag aatccattta
1321 taactcttac aatatatgaa aaatttctgc cagcttttat ttatgtgggt tatatttatg
1381 actacttctc atttgtaaaa ctgaaataaa aagatcttgc atatttgtat taatttaaaa
1441 aaaaaaaaaa aa
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