LOCUS BC026251 2181 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens phenylalanine hydroxylase, mRNA (cDNA clone MGC:22457
IMAGE:4767736), complete cds.
ACCESSION BC026251
VERSION BC026251.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2181)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2181)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (02-APR-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: CLONTECH
cDNA Library Preparation: CLONTECH Laboratories, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 37 Row: k Column: 23
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 4557818.
FEATURES Location/Qualifiers
source 1..2181
/db_xref="H-InvDB:HIT000040161"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:22457 IMAGE:4767736"
/tissue_type="Liver"
/clone_lib="NIH_MGC_76"
/lab_host="DH10B"
/note="Vector: pDNR-LIB"
gene 1..2181
/gene="PAH"
/gene_synonym="PKU"
/gene_synonym="PKU1"
/db_xref="GeneID:5053"
/db_xref="HGNC:HGNC:8582"
/db_xref="MIM:261600"
CDS 154..1512
/gene="PAH"
/gene_synonym="PKU"
/gene_synonym="PKU1"
/codon_start=1
/product="phenylalanine hydroxylase"
/protein_id="AAH26251.1"
/db_xref="GeneID:5053"
/db_xref="HGNC:HGNC:8582"
/db_xref="MIM:261600"
/translation="MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEE
VGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFFTHLDKRSLPALTNIIKILRHDI
GATVHELSRDKKKDTVPWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQ
FADIAYNYRHGQPIPRVEYMEEGKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCG
FHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPM
YTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLC
KQGDSIKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESF
NDAKEKVRNFAATIPRPFSVRYDPYTQRIEVLDNTQQLKILADSINSEIGILCSALQK
IK"
BASE COUNT 662 a 489 c 436 g 594 t
ORIGIN
1 actgtgcgga gatgcaccac gcaagagaca ccctttgtaa ctctcttctc ctccctagtg
61 cgaggttaaa accttcagcc ccccgtgctg tttgcaaacc tgcctgtacc tgaggcccta
121 aaaagccaga gacctcactc ccggggagcc agcatgtcca ctgcggtcct ggaaaaccca
181 ggcttgggca ggaaactctc tgactttgga caggaaacaa gctatattga agacaactgc
241 aatcaaaatg gtgccatatc gctgatcttc tcactcaaag aagaagttgg tgcattggcc
301 aaagtattgc gcttatttga ggagaatgat gtaaacctga cccacattga atctagacct
361 tctcgtttaa agaaagatga gtatgaattt ttcacccatt tggataaacg tagcctgcct
421 gctctgacaa acatcatcaa gatcttgagg catgacattg gtgccactgt ccatgagctt
481 tcacgagata agaagaaaga cacagtgccc tggttcccaa gaaccattca agagctggac
541 agatttgcca atcagattct cagctatgga gcggaactgg atgctgacca ccctggtttt
601 aaagatcctg tgtaccgtgc aagacggaag cagtttgctg acattgccta caactaccgc
661 catgggcagc ccatccctcg agtggaatac atggaggaag gaaagaaaac atggggcaca
721 gtgttcaaga ctctgaagtc cttgtataaa acccatgctt gctatgagta caatcacatt
781 tttccacttc ttgaaaagta ctgtggcttc catgaagata acattcccca gctggaagac
841 gtttctcagt tcctgcagac ttgcactggt ttccgcctcc gacctgtggc tggcctgctt
901 tcctctcggg atttcttggg tggcctggcc ttccgagtct tccactgcac acagtacatc
961 agacatggat ccaagcccat gtataccccc gaacctgaca tctgccatga gctgttggga
1021 catgtgccct tgttttcaga tcgcagcttt gcccagtttt cccaggaaat tggccttgcc
1081 tctctgggtg cacctgatga atacattgaa aagctcgcca caatttactg gtttactgtg
1141 gagtttgggc tctgcaaaca aggagactcc ataaaggcat atggtgctgg gctcctgtca
1201 tcctttggtg aattacagta ctgcttatca gagaagccaa agcttctccc cctggagctg
1261 gagaagacag ccatccaaaa ttacactgtc acggagttcc agcccctcta ttacgtggca
1321 gagagtttta atgatgccaa ggagaaagta aggaactttg ctgccacaat acctcggccc
1381 ttctcagttc gctacgaccc atacacccaa aggattgagg tcttggacaa tacccagcag
1441 cttaagattt tggctgattc cattaacagt gaaattggaa tcctttgcag tgccctccag
1501 aaaataaagt aaagccatgg acagaatgtg gtctgtcagc tgtgaatctg ttgatggaga
1561 tccaactatt tctttcatca gaaaaagtcc gaaaagcaaa ccttaatttg aaataacagc
1621 cttaaatcct ttacaagatg gagaaacaac aaataagtca aaataatctg aaatgacagg
1681 atatgagtac atactcaaga gcataatggt aaatcttttg gggtcatctt tgatttagag
1741 atgataatcc catactctca attgagttaa atcagtaatc tgtcgcattt catcaagatt
1801 aattaaaatt tgggacctgc ttcattcaag cttcatatat gctttgcaga gaactcataa
1861 aggagcatat aaggctaaat gtaaaacaca agactgtcat tagaattgaa ttattgggct
1921 taatataaat cgtaacctat gaagtttatt ttctatttta gttaactatg attccaatta
1981 ctactttgtt attgtaccta agtaaatttt ctttaagtca gaagcccatt aaaatagtta
2041 caagcattga acttctttag tattatatta atataaaaac atttttgtat gttttattgt
2101 aatcataaat actgctgtat aaggtaataa aactctgcac ctaatcccca taaaaaaaaa
2161 aaaaaaaaaa aaaaaaaaaa a
//