LOCUS       BC025415                2920 bp    mRNA    linear   HUM 07-AUG-2008
DEFINITION  Homo sapiens GTP cyclohydrolase 1, mRNA (cDNA clone MGC:12737
            IMAGE:4129035), complete cds.
ACCESSION   BC025415
VERSION     BC025415.2
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2920)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 2920)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAR-2002) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     On Aug 19, 2003 this sequence version replaced BC025415.1.
            Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: ATCC
            cDNA Library Preparation: Rubin Laboratory
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: National Institutes of Health Intramural
            Sequencing Center (NISC),
            Gaithersburg, Maryland;
            Web site: http://www.nisc.nih.gov/
            Contact: nisc_mgc@nhgri.nih.gov
            Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
            Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
            Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
            Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
            Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
            McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
            Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
            Young,A., Zhang,L.-H. and Green,E.D.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAL Plate: 17 Row: h Column: 1
            This clone was selected for full length sequencing because it
            passed the following selection criteria: matched mRNA gi: 66932966.
FEATURES             Location/Qualifiers
     source          1..2920
                     /db_xref="H-InvDB:HIT000039940"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:12737 IMAGE:4129035"
                     /tissue_type="Brain, neuroblastoma"
                     /clone_lib="NIH_MGC_19"
                     /lab_host="DH10B-R"
                     /note="Vector: pOTB7"
     gene            1..2920
                     /gene="GCH1"
                     /gene_synonym="GTP-CH-1"
                     /gene_synonym="GTPCH1"
                     /db_xref="GeneID:2643"
                     /db_xref="HGNC:HGNC:4193"
                     /db_xref="MIM:600225"
     CDS             149..901
                     /gene="GCH1"
                     /gene_synonym="GTP-CH-1"
                     /gene_synonym="GTPCH1"
                     /codon_start=1
                     /product="GTP cyclohydrolase 1"
                     /protein_id="AAH25415.1"
                     /db_xref="GeneID:2643"
                     /db_xref="HGNC:HGNC:4193"
                     /db_xref="MIM:600225"
                     /translation="MEKGPVRAPAEKPRGARCSNGFPERDPPRPGPSRPAEKPPRPEA
                     KSAQPADGWKGERPRSEEDNELNLPNLAAAYSSILSSLGENPQRQGLLKTPWRAASAM
                     QFFTKGYQETISDVLNDAIFDEDHDEMVIVKDIDMFSMCEHHLVPFVGKVHIGYLPNK
                     QVLGLSKLARIVEIYSRRLQVQERLTKQIAVAITEALRPAGVGVVVEATHMCMVMRGV
                     QKMNSKTVTSTMLGVFREDPKTREEFLTLIRS"
BASE COUNT          773 a          591 c          651 g          905 t
ORIGIN      
        1 ccggctcgga gtgtgatcta agcaggtcgc gtaccttcct caggtgactc cggccacagc
       61 ccattgtccg cggccaccgg cggagtttag ccgcagacct cgaagcgccc cggggtcctt
      121 cccgaacggc agcggctgcg gcgggtccat ggagaagggc cctgtgcggg caccggcgga
      181 gaagccgcgg ggcgccaggt gcagcaatgg gttccccgag cgggatccgc cgcggcccgg
      241 gcccagcagg ccggcggaga agcccccgcg gcccgaggcc aagagcgcgc agcccgcgga
      301 cggctggaag ggcgagcggc cccgcagcga ggaggataac gagctgaacc tccctaacct
      361 ggcagccgcc tactcgtcca tcctgagctc gctgggcgag aacccccagc ggcaagggct
      421 gctcaagacg ccctggaggg cggcctcggc catgcagttc ttcaccaagg gctaccagga
      481 gaccatctca gatgtcctaa acgatgctat atttgatgaa gatcatgatg agatggtgat
      541 tgtgaaggac atagacatgt tttccatgtg tgagcatcac ttggttccat ttgttggaaa
      601 ggtccatatt ggttatcttc ctaacaagca agtccttggc ctcagcaaac ttgcgaggat
      661 tgtagaaatc tatagtagaa gactacaagt tcaggagcgc cttacaaaac aaattgctgt
      721 agcaatcacg gaagccttgc ggcctgctgg agtcggggta gtggttgaag caacacacat
      781 gtgtatggta atgcgaggtg tacagaaaat gaacagcaaa actgtgacca gcacaatgtt
      841 gggtgtgttc cgggaggatc caaagactcg ggaagagttc ctgactctca ttaggagctg
      901 agcttcattc agtgtgtgtg cgttggttgc cgatcgtact gccagtagca ttgtctgtct
      961 gtccggtctt gtttgtacat tccattttca attgttacag atgtgaactt tattccttgt
     1021 cactaattat atttaaaatt atttctagga agtcaaataa atataataaa gggttgagcc
     1081 ctctactttc ttcttgccac ctttttgtgg caatattaaa gtgaactgct aatagtgtaa
     1141 gtacgtgcac aaaaccactg ccagataacc agaggggcct gggaagggag aagaattagt
     1201 gtattttttt caaatagtac agtaatttgc ctcataagca taggagcatt gggaatgaga
     1261 gggaactgtg cccagtatac tgtttttttt cttcctccaa taaaagtggt gtagtgccga
     1321 aagtgctaaa atatttagtg cggtattgct ctgtgaattc aagttcaaca gacttcactt
     1381 tggtcatgtt tattaaacca ccagtgacat ttaaaaatat atttttagca gtcgtaatgt
     1441 tagtcaccaa gggaaggtgg tggaatgtct atgtttttga ttttactgtg agttaaaaag
     1501 gcacatttct accttctatt gtttttaaat tcaagaatag ggaattagtt cctggtgttg
     1561 tttacgagtg tattctcgtg tcaacataca gggatttaga catttaactc tctgtgcctt
     1621 gataagaata tcatttagag tgtagatact tttgcctttt taaaaaagcc attattttat
     1681 gagacttagt actcacactg caaataacta gtcagctcag ttttaacttt ataggtttat
     1741 tgagtttcct ttgtgtgatc catgtagatg cctcaaaatg tttcttcttc ttcttttttt
     1801 taatcttata agatattttt ctaagtattt ccagaaacat ttgagagtgc ccatcatttt
     1861 caggtctgca gaaccatagc ttccacgcac ctgaacgagc acagaatgaa ctgacggtgg
     1921 aagacattat gagctgtgtc caacgtttta accaaagcgt atcgtaccaa cgatctgtga
     1981 aaatgcactg gaagcttctg gtcccggttt cctttgtggt ctatgtgggt cttgtcctca
     2041 ttgtaactcc gtatagatgg tataggtatt ttaatcctgg aagctgttgc cttattaatg
     2101 attatcttaa aatttcctcc attggggcag cgtgggccaa attaaaacaa acaaaaccgc
     2161 aactcctcca cagaaacaca aacacagtta ttccatgaag tttagtattt ggttgacata
     2221 gtgctcttca aattcatccc attaccctaa aagtaataac tttgatgctt gctttaactt
     2281 tagtcccatc tctgccactt tgatgctatt tgggttatga tggggcaaga tggcagaggt
     2341 attgggtttt ttttgttttt ttccattcct ctctacttct gtttcctagc tttttctttc
     2401 tggagtttaa gtacagtgat ggttggcttg agtacctttt taaatctagc ccagtataaa
     2461 cattagcctg cttaatattt agacatttat aggtagaatt ctgagcactc aactcatgtt
     2521 tggcatttta aagtaaaaac aagtgtgact tcgaggacca aagaaattgt cagctataca
     2581 tttatcttta tgaactcatt tatattcctt tttaatgact cgttgttcta acatttccta
     2641 gaagtgttct tataaaggtc taatgtatcc acaggctgtt gtcttattag taaatgcaaa
     2701 gtaatgactt tgtctgtttt actctagtct ttagtacttc aaaattacct tttcatatcc
     2761 atgatcttga gtccatttgg gggattttta agaatttgat gtatttcaat acactgttca
     2821 aaattaaatt gtttaatttt atgtatgagt atgtatgttc ctgaagttgg tcctatttaa
     2881 attattaaac tattgtaact ttaaaaaaaa aaaaaaaaaa
//