LOCUS BC025291 2487 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 1B, mRNA (cDNA clone MGC:39237 IMAGE:5019417),
complete cds.
ACCESSION BC025291
VERSION BC025291.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2487)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2487)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (05-MAR-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 42 Row: m Column: 11
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 4758221.
FEATURES Location/Qualifiers
source 1..2487
/db_xref="H-InvDB:HIT000039886"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:39237 IMAGE:5019417"
/tissue_type="Pancreas, epithelioid carcinoma"
/clone_lib="NIH_MGC_42"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..2487
/gene="DYRK1B"
/gene_synonym="MIRK"
/db_xref="GeneID:9149"
/db_xref="HGNC:HGNC:3092"
/db_xref="MIM:604556"
CDS 216..2105
/gene="DYRK1B"
/gene_synonym="MIRK"
/codon_start=1
/product="dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 1B"
/protein_id="AAH25291.1"
/db_xref="GeneID:9149"
/db_xref="HGNC:HGNC:3092"
/db_xref="MIM:604556"
/translation="MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAP
LRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVR
SGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLE
LMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLA
QQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQS
RFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPA
AMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAG
EPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSAST
SPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVP
PSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDV
SLVGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQS
TAASS"
BASE COUNT 464 a 874 c 708 g 441 t
ORIGIN
1 attactgggt aatcggggcc ctggcttgcc gcgtccgccg gataccctca gccagtgggc
61 aggtctgagc tcgggctccc cgagcagttt gagtcccctt gcccgctcct tcaggtctca
121 gcggcggtgg cagccgaggt gcaggatgca agaaggcgcc ccccggccgg gctcccgctc
181 caggcctcgc tcccctgcgg ccctctgagc ccaccatggc cgtcccaccg ggccatggtc
241 ccttctctgg cttcccaggg ccccaggagc acacgcaggt attgcctgat gtgcggctac
301 tgcctcggag gctgcccctg gccttccggg atgcaacctc agccccgctg cgtaagctct
361 ctgtggacct catcaagacc tacaagcaca tcaatgaggt atactatgcg aagaagaagc
421 ggcgggccca gcaggcgcca ccccaggatt cgagcaacaa gaaggagaag aaggtcctga
481 accatggtta tgatgacgac aaccatgact acatcgtgcg cagtggcgag cgctggctgg
541 agcgctacga aattgactcg ctcattggca aaggctcctt tggccaggtg gtgaaagcct
601 atgatcatca gacccaggag cttgtggcca tcaagatcat caagaacaaa aaggctttcc
661 tgaaccaggc ccagattgag ctgcggctgc tggagctgat gaaccagcat gacacggaga
721 tgaagtacta tatagtacac ctgaagcggc acttcatgtt ccggaaccac ctgtgcctgg
781 tatttgagct gctgtcctac aacctgtacg acctcctgcg caacacccac ttccgcggcg
841 tctcgctgaa cctgacccgg aagctggcgc agcagctctg cacggcactg ctctttctgg
901 ccacgcctga gctcagcatc attcactgcg acctcaagcc cgaaaacatc ttgctgtgca
961 accccaagcg cagcgccatc aagattgtgg acttcggcag ctcctgccag cttggccaga
1021 ggatctacca gtatatccag agccgcttct accgctcacc tgaggtgctc ctgggcacac
1081 cctacgacct ggccattgac atgtggtccc tgggctgcat ccttgtggag atgcacaccg
1141 gagagcccct cttcagtggc tccaatgagg tcgaccagat gaaccgcatt gtggaggtgc
1201 tgggcatccc accggccgcc atgctggacc aggcgcccaa ggctcgcaag tactttgaac
1261 ggctgcctgg gggtggctgg accctacgaa ggacgaaaga actcaggaag gattaccagg
1321 gccccgggac acggcggctg caggaggtgc tgggcgtgca gacgggcggg cccgggggcc
1381 ggcgggcggg ggagccgggc cacagccccg ccgactacct ccgcttccag gacctggtgc
1441 tgcgcatgct ggagtatgag cccgccgccc gcatcagccc cctgggggct ctgcagcacg
1501 gcttcttccg ccgcacggcc gacgaggcca ccaacacggg cccggcaggc agcagtgcct
1561 ccacctcgcc cgcgcccctc gacacctgcc cctcttccag caccgccagc tccatctcca
1621 gttctggagg ctccagtggc tcctccagtg acaaccggac ctaccgctac agcaaccgat
1681 attgtggggg ccctgggccc cctatcacag actgtgagat gaacagcccc caggtcccac
1741 cctcccagcc gctgcggccc tgggcagggg gtgatgtgcc ccacaagaca catcaagccc
1801 ctgcctctgc ctcgtcactg cctgggaccg gggcccagtt acccccccag ccccgatacc
1861 ttggtcgtcc cccatcacca acctcaccac cacccccgga gctgatggat gtgagcctgg
1921 tgggcggccc tgctgactgc tccccacctc acccagcgcc tgccccccag cacccggctg
1981 cctcagccct ccggactcgg atgactggag gtcgtccacc cctcccgcct cctgatgacc
2041 ctgccactct ggggcctcac ctgggcctcc gtggtgtacc ccagagcaca gcagccagct
2101 cgtgaccctg ccccctccct ggggcccctc ctgaagccat accctccccc atctgggggc
2161 cctgggctcc catcctcatc tctctccttg actggaattg ctgctaccca gctggggtgg
2221 gtgaggcctg cactgattgg ggcctggggc aggggggtca aggagagggt tttggccgct
2281 ccctccccac taaggactgg acccttgggc ccctctcccc ctttttttct atttattgta
2341 ccaaagacag tggtggtccg gtggagggaa gaccccccct caccccagga ccctaggagg
2401 gggtgggggc aggtaggggg agatggcctt gctcctcctc gctgtacccc cagtaaagag
2461 ctttctcaca aaaaaaaaaa aaaaaaa
//