LOCUS       BC020567                4125 bp    mRNA    linear   HUM 06-OCT-2003
DEFINITION  Homo sapiens rho/rac guanine nucleotide exchange factor (GEF) 2,
            mRNA (cDNA clone MGC:21557 IMAGE:4157775), complete cds.
ACCESSION   BC020567
VERSION     BC020567.1
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4125)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 4125)
  AUTHORS   Strausberg,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-JAN-2002) National Institutes of Health, Mammalian
            Gene Collection (MGC), Cancer Genomics Office, National Cancer
            Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
            USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: David N. Louis, M.D.
            cDNA Library Preparation: Life Technologies, Inc.
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: Sequencing Group at the Stanford Human Genome
            Center, Stanford University School of Medicine, Stanford, CA  94305
            Web site:       http://www-shgc.stanford.edu
            Contact:  (Dickson, Mark) mcd@paxil.stanford.edu
            Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
            R. M.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAK Plate: 20 Row: c Column: 24
            This clone was selected for full length sequencing because it
            passed the following selection criteria: Similarity but not
            identity to protein.
FEATURES             Location/Qualifiers
     source          1..4125
                     /db_xref="H-InvDB:HIT000038828"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:21557 IMAGE:4157775"
                     /tissue_type="Brain, anaplastic oligodendroglioma with
                     1p/19q loss"
                     /clone_lib="NCI_CGAP_Brn67"
                     /lab_host="DH10B"
                     /note="Vector: pCMV-SPORT6"
     gene            1..4125
                     /gene="ARHGEF2"
                     /gene_synonym="DKFZp547L106"
                     /gene_synonym="GEF"
                     /gene_synonym="GEF-H1"
                     /gene_synonym="GEFH1"
                     /gene_synonym="KIAA0651"
                     /gene_synonym="LFP40"
                     /gene_synonym="P40"
                     /db_xref="GeneID:9181"
                     /db_xref="MIM:607560"
     CDS             182..3061
                     /gene="ARHGEF2"
                     /gene_synonym="DKFZp547L106"
                     /gene_synonym="GEF"
                     /gene_synonym="GEF-H1"
                     /gene_synonym="GEFH1"
                     /gene_synonym="KIAA0651"
                     /gene_synonym="LFP40"
                     /gene_synonym="P40"
                     /codon_start=1
                     /product="ARHGEF2 protein"
                     /protein_id="AAH20567.1"
                     /db_xref="GeneID:9181"
                     /db_xref="MIM:607560"
                     /translation="MKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTC
                     NVTIHNRCKDTLANCTKVKQKQQKAALLKNNTALQSVSLRSKTTIRERPSSAIYPSDS
                     FRQSLLGSRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSV
                     ESLIDEAEVIYSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQ
                     TELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQ
                     ALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKR
                     FQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTAL
                     GLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGREELLRRKLIHDG
                     CLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQE
                     KGMFLISAAPPEMYEVHTASRDDRSTWIRVIQQSVRTCPSREDFPLIETEDEAYLRRI
                     KMELQQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESPRG
                     ERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSPGVTANGEARTFN
                     GSIELCRADSDSSQRDRNGNQLRSPQEEALQRLVNLYGLLHGLQAAVAQQDTLMEARF
                     PEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCRRLG
                     EERATEAGSLEARLRESEQARALLEREAEEARRQLAALGQTEPLPAEAPWARRPVDPR
                     RRSLPAGDALYLSFNPPQPSRGTDRLDLPVTTRSVHRNFEDRERQELGSPEERLQDSS
                     DPDTGSEEEGSSRLSPPHSPRDFTRMQDIPEETESRDGEAVASES"
     misc_feature    218..358
                     /gene="ARHGEF2"
                     /gene_synonym="DKFZp547L106"
                     /gene_synonym="GEF"
                     /gene_synonym="GEF-H1"
                     /gene_synonym="GEFH1"
                     /gene_synonym="KIAA0651"
                     /gene_synonym="LFP40"
                     /gene_synonym="P40"
                     /note="C1; Region: Protein kinase C conserved region 1
                     (C1) domains (Cysteine-rich domains)"
                     /db_xref="CDD:smart00109"
     misc_feature    815..1393
                     /gene="ARHGEF2"
                     /gene_synonym="DKFZp547L106"
                     /gene_synonym="GEF"
                     /gene_synonym="GEF-H1"
                     /gene_synonym="GEFH1"
                     /gene_synonym="KIAA0651"
                     /gene_synonym="LFP40"
                     /gene_synonym="P40"
                     /note="RhoGEF; Region: Guanine nucleotide exchange factor
                     for Rho/Rac/Cdc42-like GTPases"
                     /db_xref="CDD:smart00325"
BASE COUNT          954 a         1183 c         1168 g          820 t
ORIGIN      
        1 gagaccaacg cgtgcgggcc gaacccctcc ccccgccttc ccccaacaat acaggacgcc
       61 ggggtccgcg ccgcgtcctc cctggtcccc ccgtccgatt atgtctcgga tcgaatccct
      121 cacgcgggcg cggatcgacc ggagcagaga gctggcgagc aagacccggg aaaaggagaa
      181 gatgaaggaa gccaaggatg cccgctatac caatgggcac ctcttcacca ccatttcagt
      241 ttcaggcatg accatgtgct atgcctgtaa caagagcatc acagccaagg aagccctcat
      301 ctgcccaacc tgcaatgtga ctatccacaa ccgctgtaaa gacaccctcg ccaactgtac
      361 caaggtcaag cagaagcaac agaaagcggc cctgctgaag aacaacaccg ccttgcagtc
      421 cgtttctctt cgaagtaaga caaccatccg ggagcggcca agctcggcca tctacccctc
      481 cgacagcttc cggcagtccc tcctgggctc ccgccgtggc cgctcctcct tgtctttagc
      541 caagagtgtt tctaccacca acattgctgg acatttcaat gatgagtctc ccctggggct
      601 gcgccggatc ctctcacagt ccacagactc cctcaacatg cggaaccgaa ccctatccgt
      661 ggaatccctc attgacgaag cagaggtaat ctacagtgag ctgatgagtg actttgagat
      721 ggatgagaag gactttgcag ctgactcttg gagtcttgct gtggacagca gcttcctgca
      781 gcagcataaa aaggaggtga tgaagcagca agatgtcatc tatgagctaa tccagacaga
      841 gctgcaccat gtgaggacac tgaagatcat gacccgcctc ttccgcacgg ggatgctgga
      901 agagctacac ttggagccag gagtggtcca gggcctgttc ccctgcgtgg acgagctcag
      961 tgacatccat acacgcttcc tcagccagct attagaacgc cgacgccagg ccctgtgccc
     1021 tggcagcacc cggaactttg tcatccatcg cttgggtgat ctgctcatca gccagttctc
     1081 aggtcctagt gcggagcaga tgtgtaagac ctactcggag ttctgcagcc gccacagcaa
     1141 ggccttaaag ctctataagg agctgtacgc ccgagacaaa cgcttccagc aattcatccg
     1201 gaaagtgacc cgccccgccg tgctcaagcg gcacggggta caggagtgca tcctgctggt
     1261 gactcagcgc atcaccaagt acccgttact catcagccgc atcctgcagc attcccacgg
     1321 gatcgaggag gagcgccagg acctgaccac agcactgggg ctagtgaagg agctgctgtc
     1381 caatgtggac gagggtattt atcagctgga gaaaggggcc cgtctgcagg agatctacaa
     1441 ccgcatggac cctcgggccc aaaccccagt gcctggcaag ggcccctttg gccgagagga
     1501 acttctgagg cgcaaactca tccacgatgg ctgcctgctc tggaagacag cgacggggcg
     1561 cttcaaagat gtgctagtgc tgctgatgac agatgtactg gtgtttctcc aggaaaagga
     1621 ccagaagtac atctttccta ccctggacaa gccttcagtg gtatcgctgc agaatctaat
     1681 cgtacgagac attgccaacc aggagaaagg gatgtttctg atcagcgcag ccccacctga
     1741 gatgtacgag gtgcacacag catcccggga tgaccggagc acctggatcc gggtcattca
     1801 gcagagcgtg cgcacatgcc catccaggga ggacttcccc ctgattgaga cagaggatga
     1861 ggcttacctg cggcgaatta agatggagtt gcagcagaag gaccgggcac tggtggagct
     1921 gctgcgagag aaggtcgggc tgtttgctga gatgacccat ttccaggccg aagaggatgg
     1981 tggcagtggg atggccctgc ccaccctgcc caggggcctt ttccgctctg agtcccttga
     2041 gtcccctcgt ggcgagcggc tgctgcagga tgccatccgt gaggtggagg gtctgaaaga
     2101 cctgctggtg gggccaggag tggaactgct cttgacaccc cgagagccag ccctgccctt
     2161 ggaaccagac agcggtggta acacgagtcc tggggtcact gccaatggtg aggccagaac
     2221 cttcaatggc tccattgaac tctgcagagc tgactcagac tctagccaga gggatcgaaa
     2281 tggaaatcag ctgagatcac cgcaagagga ggcgttacag cgattggtca atctctatgg
     2341 acttctacat ggcctacagg cagctgtggc ccagcaggac actctgatgg aagcccggtt
     2401 ccctgagggc cctgagcggc gggagaagct gtgccgagcc aactctcggg atggggaggc
     2461 tggcagggct ggggctgccc ctgtggcccc tgaaaagcag gccacggaac tggcattact
     2521 gcagcggcaa catgcgctgc tgcaggagga gctacggcgc tgccggcggc taggtgaaga
     2581 acgggcaacc gaagctggca gcctggaggc ccggctccgg gagagtgagc aggcccgggc
     2641 actgctggag cgtgaggccg aagaggctcg aaggcagctg gccgccctgg gccagaccga
     2701 gccactccca gctgaggccc cctgggcccg cagacctgtg gatcctcggc ggcgcagcct
     2761 ccccgcaggc gatgccctgt acttgagttt caacccccca cagcccagcc gaggcactga
     2821 ccgcctggat ctacctgtca ctactcgctc tgtccatcga aactttgagg accgagagag
     2881 gcaggaactg gggagccccg aagagcggct gcaagacagc agtgaccctg acactggcag
     2941 cgaggaggaa ggtagcagcc gtctgtctcc gccccacagt ccacgagact ttaccagaat
     3001 gcaggacatc ccggaggaga cggagagccg cgacggggag gctgtagcct ccgagagcta
     3061 agggggcccc tcccccctgc cccgtgcccc actgaagaac attactgagg gggctaacct
     3121 tggggactcc aatttgccaa tgatgaggga acatttgaaa gaactgcaaa ttgtccttgc
     3181 cagctcttgg gatccttgga tacctggggc catttaagaa gctaggggaa ttaggccaca
     3241 acaccccctg ggacatccga aagctacacc acagatgcca gtggttcatg ccttcttccc
     3301 gcaactttag gaaaatttat ttatttattg tttattagtt atggggggag aggggagatt
     3361 taaaggacca gggacatggg aaccaagcca tagggatcag agggccttgt ccttgaacac
     3421 tactggggta tattcaggct catccacgca gctgctgggt tcttgcccta acggccctcc
     3481 cctgcaacat ccgtcttgga ggagaggctg cagccacagc accctactgc cctttaaata
     3541 aaggagggct gtgggcaggg ccatgtccct ttctcctctc ccctcaacct cttactgctg
     3601 ttctcccttt ctccgtcctt catggaagcc ctgggagata acctggcttc ctggagttga
     3661 tggaataaag gttggggtgg ccataatggt ttgttggggg tgagggaaaa aacccacagg
     3721 gaccagaatg ttttgttgtt cttttgtttt cttttttgta ccaaagtcaa ctgcacgtgt
     3781 ttttatattt ttaagagatc gtaggcaatt agagatcgaa gcctcctatc tccacatctc
     3841 tgaagaagtt gaggggtggg ggagagaatg acttctgcct tcatctgcag taacgggggg
     3901 acctatactg acctcttccc cagccattta gaaacaagtt ctagggtggg ttggaaaatc
     3961 tccaagagcc ctgacctcat cttccacctc agcaaccatg acctgaaacc tcagcgtgaa
     4021 tttgggggat ttttcagtgg aacccttgcc cccaaatgtc gaccagcccc caaatgtcga
     4081 agaattttct tcttgccaat tttgttgttt aaaaaaaaaa aaaaa
//