LOCUS BC019334 2447 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens serine/threonine kinase 11, mRNA (cDNA clone MGC:12715
IMAGE:3946005), complete cds.
ACCESSION BC019334
VERSION BC019334.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2447)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2447)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (13-DEC-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: DCTD/DTP
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 18 Row: l Column: 8
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 58530881.
FEATURES Location/Qualifiers
source 1..2447
/db_xref="H-InvDB:HIT000038645"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:12715 IMAGE:3946005"
/tissue_type="Lung, small cell carcinoma"
/clone_lib="NIH_MGC_7"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..2447
/gene="STK11"
/gene_synonym="LKB1"
/gene_synonym="PJS"
/db_xref="GeneID:6794"
/db_xref="HGNC:HGNC:11389"
/db_xref="MIM:602216"
CDS 272..1573
/gene="STK11"
/gene_synonym="LKB1"
/gene_synonym="PJS"
/codon_start=1
/product="serine/threonine kinase 11"
/protein_id="AAH19334.1"
/db_xref="GeneID:6794"
/db_xref="HGNC:HGNC:11389"
/db_xref="MIM:602216"
/translation="MEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIYQPRRKRAK
LIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLL
RRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQL
IDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPA
FQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPG
DCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRS
MTVVPYLEDLHGADEDEDLFDIEDDIIYTQDFTVPGQVPEEEASHNGQRRGLPKAVCM
NGTEAAQLSTKSRAEGRAPNPARKACSASSKIRRLSACKQQ"
BASE COUNT 491 a 734 c 789 g 433 t
ORIGIN
1 ctggaactcg cgtctgagcc gccgtcccgg acccccggtg cccgccggtc cgcagaccct
61 gcaccgggct tggactcgca gccgggactg acgtgtagaa caatcgtttc tgttggaaga
121 agggtttttc ccttcctttt ggggtttttg ttgccttttt tttttctttt ttctttgtaa
181 aattttggag aagggaagtc ggaacacaag gaaggaccgc tcacccgcgg actcagggct
241 ggcggcggga ctccaggacc ctgggtccag catggaggtg gtggacccgc agcagctggg
301 catgttcacg gagggcgagc tgatgtcggt gggtatggac acgttcatcc accgcatcga
361 ctccaccgag gtcatctacc agccgcgccg caagcgggcc aagctcatcg gcaagtacct
421 gatgggggac ctgctggggg aaggctctta cggcaaggtg aaggaggtgc tggactcgga
481 gacgctgtgc aggagggccg tcaagatcct caagaagaag aagttgcgaa ggatccccaa
541 cggggaggcc aacgtgaaga aggaaattca actactgagg aggttacggc acaaaaatgt
601 catccagctg gtggatgtgt tatacaacga agagaagcag aaaatgtata tggtgatgga
661 gtactgcgtg tgtggcatgc aggaaatgct ggacagcgtg ccggagaagc gtttcccagt
721 gtgccaggcc cacgggtact tctgtcagct gattgacggc ctggagtacc tgcatagcca
781 gggcattgtg cacaaggaca tcaagccggg gaacctgctg ctcaccaccg gtggcaccct
841 caaaatctcc gacctgggcg tggccgaggc actgcacccg ttcgcggcgg acgacacctg
901 ccggaccagc cagggctccc cggctttcca gccgcccgag attgccaacg gcctggacac
961 cttctccggc ttcaaggtgg acatctggtc ggctggggtc accctctaca acatcaccac
1021 gggtctgtac cccttcgaag gggacaacat ctacaagttg tttgagaaca tcgggaaggg
1081 gagctacgcc atcccgggcg actgtggccc cccgctctct gacctgctga aagggatgct
1141 tgagtacgaa ccggccaaga ggttctccat ccggcagatc cggcagcaca gctggttccg
1201 gaagaaacat cctccggctg aagcaccagt gcccatccca ccgagcccag acaccaagga
1261 ccggtggcgc agcatgactg tggtgccgta cttggaggac ctgcacggcg cggacgagga
1321 cgaggacctc ttcgacatcg aggatgacat catctacact caggacttca cggtgcccgg
1381 acaggtccca gaagaggagg ccagtcacaa tggacagcgc cggggcctcc ccaaggccgt
1441 gtgtatgaac ggcacagagg cggcgcagct gagcaccaaa tccagggcgg agggccgggc
1501 ccccaaccct gcccgcaagg cctgctccgc cagcagcaag atccgccggc tgtcggcctg
1561 caagcagcag tgaggctggc cgcctgcagc ccgtgtccag gagccccgcc aggtgcccgc
1621 gccaggccct cagtcttcct gccggttccg cccgccctcc cggagaggtg gccgccatgc
1681 ttctgtgccg accacgcccc aggacctccg gagcgccctg cagggccggg cagggggaca
1741 gcagggaccg ggcgcagccc tcccccctcg gccgcccggc agtgcacgcg gcttgttgac
1801 ttcgcagccc cgggcggagc cttcccgggc gggcgtggga ggagggaggc ggcctccatg
1861 cactttatgt ggagactact ggccccgccc gtggcctcgt gctccgcagg gcgcccagcg
1921 ccgtccggcg gccccgccgc agaccagctg gcgggtgtgg agaccaggct cctgaccccg
1981 ccatgcatgc agcgccacct ggaagccgcg cggccgcttt ggttttttgt ttggttggtt
2041 ccattttctt tttttctttt tttttttaag aaaaaataaa aggtggattt gagctgtggc
2101 tgtgaggggt gtttgggagc tgctgggtgg caggggggct gtggggtcgg gctcacgtcg
2161 cggccgcctt tgcgctctcg ggtcaccccg ctttggcggc ccggccggag ggcaggaccc
2221 tcacctctcc cccaaggcca ctgcgctctt gggaccccag agaaaacccg gagcaagcag
2281 gagtgtgcgg tcaatattta tatcatccag aaaagaaaaa cacgagaaac gccatcgcgg
2341 gatggtgcag acgcggcggg gactcggagg gtgccgtgcg ggcgaggccg cccaaatttg
2401 gcaataaata aagcttggga agcttgaaaa aaaaaaaaaa aaaaaaa
//