LOCUS BC018751 2539 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 1B, mRNA (cDNA clone MGC:31947 IMAGE:4300012),
complete cds.
ACCESSION BC018751
VERSION BC018751.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2539)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2539)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (07-DEC-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 40 Row: c Column: 23
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 4758221.
FEATURES Location/Qualifiers
source 1..2539
/db_xref="H-InvDB:HIT000038439"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:31947 IMAGE:4300012"
/tissue_type="Pancreas, epithelioid carcinoma"
/clone_lib="NIH_MGC_42"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..2539
/gene="DYRK1B"
/gene_synonym="MIRK"
/db_xref="GeneID:9149"
/db_xref="HGNC:HGNC:3092"
/db_xref="MIM:604556"
CDS 265..2154
/gene="DYRK1B"
/gene_synonym="MIRK"
/codon_start=1
/product="dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 1B"
/protein_id="AAH18751.1"
/db_xref="GeneID:9149"
/db_xref="HGNC:HGNC:3092"
/db_xref="MIM:604556"
/translation="MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAP
LRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVR
SGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLE
LMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLA
QQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQS
RFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPA
AMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAG
EPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSAST
SPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVP
PSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDV
SLVGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQS
TAASS"
BASE COUNT 469 a 884 c 730 g 456 t
ORIGIN
1 ccagggcgtg ggggggccgg tttgttgtgg tcgccatttt gctggttgca ttactgggta
61 atcggggccc tggcttgccg cgtccgccgg ataccctcag ccagtgggca ggtctgagct
121 cgggctcccc gagcagtttg agtccccttg cccgctcctt caggtctcag cggcggtggc
181 agccgaggtg caggatgcaa gaaggcgccc cccggccggg ctcccgctcc aggcctcgct
241 cccctgcggc cctctgagcc caccatggcc gtcccaccgg gccatggtcc cttctctggc
301 ttcccagggc cccaggagca cacgcaggta ttgcctgatg tgcggctact gcctcggagg
361 ctgcccctgg ccttccggga tgcaacctca gccccgctgc gtaagctctc tgtggacctc
421 atcaagacct acaagcacat caatgaggta tactatgcga agaagaagcg gcgggcccag
481 caggcgccac cccaggattc gagcaacaag aaggagaaga aggtcctgaa ccatggttat
541 gatgacgaca accatgacta catcgtgcgc agtggcgagc gctggctgga gcgctacgaa
601 attgactcgc tcattggcaa aggctccttt ggccaggtgg tgaaagccta tgatcatcag
661 acccaggagc ttgtggccat caagatcatc aagaacaaaa aggctttcct gaaccaggcc
721 cagattgagc tgcggctgct ggagctgatg aaccagcatg acacggagat gaagtactat
781 atagtacacc tgaagcggca cttcatgttc cggaaccacc tgtgcctggt atttgagctg
841 ctgtcctaca acctgtacga cctcctgcgc aacacccact tccgcggcgt ctcgctgaac
901 ctgacccgga agctggcgca gcagctctgc acggcactgc tctttctggc cacgcctgag
961 ctcagcatca ttcactgcga cctcaagccc gaaaacatct tgctgtgcaa ccccaagcgc
1021 agcgccatca agattgtgga cttcggcagc tcctgccagc ttggccagag gatctaccag
1081 tatatccaga gccgcttcta ccgctcacct gaggtgctcc tgggcacacc ctacgacctg
1141 gccattgaca tgtggtccct gggctgcatc cttgtggaga tgcacaccgg agagcccctc
1201 ttcagtggct ccaatgaggt cgaccagatg aaccgcattg tggaggtgct gggcatccca
1261 ccggccgcca tgctggacca ggcgcccaag gctcgcaagt actttgaacg gctgcctggg
1321 ggtggctgga ccctacgaag gacgaaagaa ctcaggaagg attaccaggg ccccgggaca
1381 cggcggctgc aggaggtgct gggcgtgcag acgggcgggc ccgggggccg gcgggcgggg
1441 gagccgggcc acagccccgc cgactacctc cgcttccagg acctggtgct gcgcatgctg
1501 gagtatgagc ccgccgcccg catcagcccc ctgggggctc tgcagcacgg cttcttccgc
1561 cgcacggccg acgaggccac caacacgggc ccggcaggca gcagtgcctc cacctcgccc
1621 gcgcccctcg acacctgccc ctcttccagc accgccagct ccatctccag ttctggaggc
1681 tccagtggct cctccagtga caaccggacc taccgctaca gcaaccgata ttgtgggggc
1741 cctgggcccc ctatcacaga ctgtgagatg aacagccccc aggtcccacc ctcccagccg
1801 ctgcggccct gggcaggggg tgatgtgccc cacaagacac atcaagcccc tgcctctgcc
1861 tcgtcactgc ctgggaccgg ggcccagtta cccccccagc cccgatacct tggtcgtccc
1921 ccatcaccaa cctcaccacc acccccggag ctgatggatg tgagcctggt gggcggccct
1981 gctgactgct ccccacctca cccagcgcct gccccccagc acccggctgc ctcagccctc
2041 cggactcgga tgactggagg tcgtccaccc ctcccgcctc ctgatgaccc tgccactctg
2101 gggcctcacc tgggcctccg tggtgtaccc cagagcacag cagccagctc gtgaccctgc
2161 cccctccctg gggcccctcc tgaagccata ccctccccca tctgggggcc ctgggctccc
2221 atcctcatct ctctccttga ctggaattgc tgctacccag ctggggtggg tgaggcctgc
2281 actgattggg gcctggggca ggggggtcaa ggagagggtt ttggccgctc cctccccact
2341 aaggactgga cccttgggcc cctctccccc tttttttcta tttattgtac caaagacagt
2401 ggtggtccgg tggagggaag accccccctc accccaggac cctaggaggg ggtgggggca
2461 ggtaggggga gatggccttg ctcctcctcg ctgtaccccc agtaaagagc tttctcacaa
2521 aaaaaaaaaa aaaaaaaaa
//