LOCUS BC017225 2666 bp mRNA linear HUM 11-DEC-2003
DEFINITION Homo sapiens dishevelled, dsh homolog 1 (Drosophila), mRNA (cDNA
clone IMAGE:4299758), partial cds.
ACCESSION BC017225
VERSION BC017225.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2666)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2666)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (05-NOV-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Dec 9, 2003 this sequence version replaced BC017225.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 20 Row: m Column: 4.
FEATURES Location/Qualifiers
source 1..2666
/db_xref="H-InvDB:HIT000089213"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:4299758"
/tissue_type="Eye, normal, pigmented retinal epithelium"
/clone_lib="NIH_MGC_43"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene <1..2666
/gene="DVL1"
/gene_synonym="DVL"
/gene_synonym="MGC54245"
/db_xref="GeneID:1855"
/db_xref="MIM:601365"
CDS <1..1596
/gene="DVL1"
/gene_synonym="DVL"
/gene_synonym="MGC54245"
/codon_start=1
/product="DVL1 protein"
/protein_id="AAH17225.1"
/db_xref="GeneID:1855"
/db_xref="MIM:601365"
/translation="VVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSF
HPNVASSRDGMDNETGTESMVSHRRERARRRNREEAARTNGHPRGDRRRDVGLPPDSA
STALSSELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASS
FSSITDSTMSLNIVTVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGR
IEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTVPRA
DPVRPIDPAAWLSHTAALTGALPRYELEEAPLTVKSDMSAVVRVMQLPDSGLEIRDRM
WLKITIANAVIGADVVDWLYTHVEGFKERREARKYASSLLKHGFLRHTVNKITFSEQC
YYVFGDLCSNLATLNLNSGSSGTSDQDTLAPLPHPAAPWPLGQGYPYQYPGPPPCFPP
AYQDPGFSYGSGSTGSQQSEGSKSSGSTRSSRRAPGREKERRAAGAGGSGSESDHTAP
SGVGSSWRERPAGQLSRGSSPRS"
misc_feature 523..786
/gene="DVL1"
/gene_synonym="DVL"
/gene_synonym="MGC54245"
/note="PDZ; Region: PDZ domain (Also known as DHR or
GLGF). PDZ domains are found in diverse signaling
proteins"
/db_xref="CDD:pfam00595"
misc_feature 970..1188
/gene="DVL1"
/gene_synonym="DVL"
/gene_synonym="MGC54245"
/note="DEP; Region: Domain found in Dishevelled, Egl-10,
and Pleckstrin. Domain of unknown function present in
signaling proteins that contain pfam00169, rasGEF, rhoGEF,
rhoGAP, pfam00615, pfam00595 domains"
/db_xref="CDD:pfam00610"
BASE COUNT 497 a 873 c 865 g 431 t
ORIGIN
1 gtggtctcct ggctggtcct ggctgagggt gctcactcgg atgcggggtc ccagggcacg
61 gacagccaca cagacctgcc cccgcctctt gagcggacag gcggcatcgg ggactcccgg
121 cccccctcct tccacccgaa tgtggccagc agccgtgacg ggatggacaa cgagacaggc
181 acggagtcca tggtcagtca ccggcgggag cgtgcccgac gccggaaccg cgaggaggcc
241 gcccggacca atgggcaccc aaggggagac cgacggcggg atgtggggct gcccccagac
301 agcgcgtcca ccgccctcag cagcgagctt gagtccagca gctttgtgga ctcggacgag
361 gatggcagca cgagcaggct cagcagctcc acggagcaga gcacctcatc cagactcatc
421 cggaagcaca aacgccggcg gaggaagcag cgccttcggc aggcggaccg ggcctcctcc
481 ttcagcagca taaccgactc caccatgtcc ctcaacatcg tcactgtcac gctcaacatg
541 gaaagacatc actttctggg catcagcatc gtggggcaga gcaacgaccg tggagacggc
601 ggcatctaca ttggctccat catgaagggc ggggctgtgg ccgctgacgg ccgcatcgag
661 cccggcgaca tgttgctgca ggtgaatgac gtgaactttg agaacatgag caatgacgat
721 gccgtgcggg tgctgcggga gatcgtttcc cagacggggc ccatcagcct cactgtggcc
781 aagtgctggg acccaacgcc ccgaagctac ttcaccgtcc cacgggctga cccggtgcgg
841 cccatcgacc ccgccgcctg gctgtcccac acggcggcac tgacaggagc cctgccccgc
901 tacgagctgg aagaggcgcc gctgacggtg aagagtgaca tgagcgccgt cgtccgggtc
961 atgcagctgc cagactcggg actggagatc cgcgaccgca tgtggctcaa gatcaccatc
1021 gccaatgccg tcatcggggc ggacgtggtg gactggctgt acacacacgt ggagggcttc
1081 aaggagcggc gggaggcccg gaagtacgcc agcagcttgc tgaagcacgg cttcctgcgg
1141 cacacggtca acaagatcac cttctccgag cagtgctact acgtcttcgg ggatctctgc
1201 agcaatctcg ccaccctgaa cctcaacagt ggctccagtg ggacttcgga tcaggacacg
1261 ctggccccgc tgccccaccc ggctgccccc tggcctctgg gtcagggcta cccctaccag
1321 tacccgggac ccccaccctg cttcccgcct gcctaccagg acccgggctt tagctatggc
1381 agcggcagca ccgggagtca gcagagtgaa gggagcaaaa gcagtgggtc cacccggagc
1441 agccgccggg ccccgggccg tgagaaggag cgtcgggcgg cgggagctgg gggcagtggc
1501 agtgaatcgg atcacacggc accgagtggg gtggggagca gctggcgaga gcgtccggcc
1561 ggccagctca gccgtggcag cagcccacgc agttaggcct cggctaccgc cccggggctc
1621 cccccgcccc accccacgac caaggcctat acagtggtgg gggggccacc cgggggaccc
1681 cctgtccggg agctggctgc cgtccccccg gaattgacag gcagccgcca gtccttccag
1741 aaggctatgg ggaacccctg cgagttcttc gtggacatca tgtgactcgt ggcgcatgcc
1801 ccagccctgc ctgaggtggg gagctggcgg tcctgccgca tgcagagctc gcgtgggctt
1861 gccttcgtgg gggccaggac gggaggcagg gtggggggca ggctggacca ccaccatctg
1921 ccctggcagc ctggctgctc cagctcctga cagcacctgt gtctgagcag ccgtgttggg
1981 ggcgctccct ctctgcccct cagcgagagc ctcggacctc ccaacccctt gtgtctggtg
2041 gggatccctc ctgggatgag gaagaccccc tcgggctctc ggctgacccc cacctcctgc
2101 acagctgtgc ccaggccccc agggtggtcc atgcggggca accccctgcg gtgcacaggc
2161 cccctgtctg gagtagggat ctaatttatt tatttattgc ctggccggtg actcggggga
2221 ggaggcgacc ctgtcatctg tcccacctgc tgctgcccct tggagcagcc tgcaccttct
2281 ctcctcccat ccggcaacag tctgaaagta cgtggaggac gggaccggaa gacgagagag
2341 ggctggacat cctgcccacc gtgtcccagc cagggcaggg agggaccatg gcccgcaggg
2401 tcaaggggcc ccgatgtgca cagctgccac agggagggag gtcttgggga gatgggcagt
2461 caggtggccc gtccttggtg agtgcacaca ctgcgcgcac acatcgcggc cttcctggct
2521 tctctggccc ccacgtgtct gtgctgtaga tactgtatca aagtcccagc gtttagatgg
2581 ttaacataga gctgcttctg tgtaaatgct gcttatttta aacactaaaa agcgtttaat
2641 tttatgggaa aaaaaaaaaa aaaaaa
//