LOCUS BC016875 1512 bp mRNA linear HUM 04-NOV-2003
DEFINITION Homo sapiens fibronectin 1, mRNA (cDNA clone IMAGE:3886582),
partial cds.
ACCESSION BC016875
VERSION BC016875.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1512)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1512)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (05-NOV-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Sep 16, 2003 this sequence version replaced BC016875.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: DCTD/DTP/Gazdar
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 22 Row: d Column: 24.
FEATURES Location/Qualifiers
source 1..1512
/db_xref="H-InvDB:HIT000089097"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:3886582"
/tissue_type="Lung, carcinoma, large cell
undifferentiated."
/clone_lib="NIH_MGC_69"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene <1..1512
/gene="FN1"
/gene_synonym="CIG"
/gene_synonym="FINC"
/gene_synonym="FN"
/gene_synonym="LETS"
/db_xref="GeneID:2335"
/db_xref="MIM:135600"
CDS <1..808
/gene="FN1"
/gene_synonym="CIG"
/gene_synonym="FINC"
/gene_synonym="FN"
/gene_synonym="LETS"
/codon_start=2
/product="FN1 protein"
/protein_id="AAH16875.1"
/db_xref="GeneID:2335"
/db_xref="MIM:135600"
/translation="TTISWAPFQDTSEYIISCHPVGTDEEPLQFRVPGTSTSATLTGL
TRGATYNIIVEALKDQQRHKVREEVVTVGNSVNEGLNQPTDDSCFDPYTVSHYAVGDE
WERMSESGFKLLCQCLGFGSGHFRCDSSRWCHDNGVNYKIGEKWDRQGENGQMMSCTC
LGNGKGEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNCRRP
GGEPSPEGTTGQSYNQYSQRYHQRTNTNVNCPIECFMPLDVQADREDSRE"
misc_feature 263..397
/gene="FN1"
/gene_synonym="CIG"
/gene_synonym="FINC"
/gene_synonym="FN"
/gene_synonym="LETS"
/note="Region: Fibronectin type 1 domain"
/db_xref="CDD:smart00058"
misc_feature 398..523
/gene="FN1"
/gene_synonym="CIG"
/gene_synonym="FINC"
/gene_synonym="FN"
/gene_synonym="LETS"
/note="Region: Fibronectin type 1 domain"
/db_xref="CDD:smart00058"
misc_feature 527..646
/gene="FN1"
/gene_synonym="CIG"
/gene_synonym="FINC"
/gene_synonym="FN"
/gene_synonym="LETS"
/note="Region: Fibronectin type 1 domain, approximately 40
residue long with two conserved disulfide bridges. FN1 is
one of three types of internal repeats which combine to
form larger domains within fibronectin. Fibronectin, a
plasma protein that binds cell surfaces and various
compounds including collagen, fibrin, heparin, DNA, and
actin, usually exists as a dimer in plasma and as an
insoluble multimer in extracellular matrices. Dimers of
nearly identical subunits are linked by a disulfide bond
close to their C-terminus. FN1 domains also found in
coagulation factor XII, HGF activator, and tissue-type
plasminogen activator. In tissue plasminogen activator,
FN1 domains may form functional fibrin-binding units with
EGF-like domains C-terminal to FN1"
/db_xref="CDD:cd00061"
BASE COUNT 437 a 320 c 339 g 416 t
ORIGIN
1 gacaaccatc tcatgggccc cattccagga cacttctgag tacatcattt catgtcatcc
61 tgttggcact gatgaagaac ccttacagtt cagggttcct ggaacttcta ccagtgccac
121 tctgacaggc ctcaccagag gtgccaccta caacatcata gtggaggcac tgaaagacca
181 gcagaggcat aaggttcggg aagaggttgt taccgtgggc aactctgtca acgaaggctt
241 gaaccaacct acggatgact cgtgctttga cccctacaca gtttcccatt atgccgttgg
301 agatgagtgg gaacgaatgt ctgaatcagg ctttaaactg ttgtgccagt gcttaggctt
361 tggaagtggt catttcagat gtgattcatc tagatggtgc catgacaatg gtgtgaacta
421 caagattgga gagaagtggg accgtcaggg agaaaatggc cagatgatga gctgcacatg
481 tcttgggaac ggaaaaggag aattcaagtg tgaccctcat gaggcaacgt gttacgatga
541 tgggaagaca taccacgtag gagaacagtg gcagaaggaa tatctcggtg ccatttgctc
601 ctgcacatgc tttggaggcc agcggggctg gcgctgtgac aactgccgca gacctggggg
661 tgaacccagt cccgaaggca ctactggcca gtcctacaac cagtattctc agagatacca
721 tcagagaaca aacactaatg ttaattgccc aattgagtgc ttcatgcctt tagatgtaca
781 ggctgacaga gaagattccc gagagtaaat catctttcca atccagagga acaagcatgt
841 ctctctgcca agatccatct aaactggagt gatgttagca gacccagctt agagttcttc
901 tttctttctt aagccctttg ctctggagga agttctccag cttcagctca actcacagct
961 tctccaagca tcaccctggg agtttcctga gggttttctc ataaatgagg gctgcacatt
1021 gcctgttctg cttcgaagta ttcaataccg ctcagtattt taaatgaagt gattctaaga
1081 tttggtttgg gatcaatagg aaagcatatg cagccaacca agatgcaaat gttttgaaat
1141 gatatgacca aaattttaag taggaaagtc acccaaacac ttctgctttc acttaagtgt
1201 ctggcccgca atactgtagg aacaagcatg atcttgttac tgtgatattt taaatatcca
1261 cagtactcac tttttccaaa tgatcctagt aattgcctag aaatatcttt ctcttacctg
1321 ttatttatca atttttccca gtatttttat acggaaaaaa ttgtattgaa aacacttagt
1381 atgcagttga taagaggaat ttggtataat tatggtgggt gattattttt tatactgtat
1441 gtgccaaagc tttactactg tggaaagaca actgttttaa taaaagattt acattccaaa
1501 aaaaaaaaaa aa
//