LOCUS BC015914 2546 bp mRNA linear HUM 03-NOV-2008
DEFINITION Homo sapiens mitogen-activated protein kinase kinase kinase 6, mRNA
(cDNA clone IMAGE:4620349), partial cds.
ACCESSION BC015914
VERSION BC015914.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2546)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2546)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (15-OCT-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC/DCTD/DTP
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 29 Row: i Column: 20.
FEATURES Location/Qualifiers
source 1..2546
/db_xref="H-InvDB:HIT000037391"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:4620349"
/tissue_type="Skin, melanotic melanoma."
/clone_lib="NIH_MGC_20"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene <1..2546
/gene="MAP3K6"
/gene_synonym="ASK2"
/gene_synonym="MAPKKK6"
/db_xref="GeneID:9064"
/db_xref="HGNC:HGNC:6858"
/db_xref="MIM:604468"
CDS <1..2396
/gene="MAP3K6"
/gene_synonym="ASK2"
/gene_synonym="MAPKKK6"
/codon_start=3
/product="MAP3K6 protein"
/protein_id="AAH15914.1"
/db_xref="GeneID:9064"
/db_xref="HGNC:HGNC:6858"
/db_xref="MIM:604468"
/translation="MNLLLSYRDVQDYSAIIELVETLQALPTCDVAEQHNVCFHYTFA
LNRRNRPGDRAKALSVLLPLVQLEGSVAPDLYCMCGRIYKDMFFSSGFQDAGHREQAY
HWYRKAFDVEPSLHSGINAAVLLIAAGQHFEDSKELRLIGMKLGCLLARKGCVEKMQY
YWDVGFYLGAQILANDPTQVVLAAEQLYKLNAPIWYLVSVMETFLLYQHFRPTPEPPG
GPPRRAHFWLHFLLQSCQPFKTACAQGDQCLVLVLEMNKVLLPAKLEVRGTDPVSTVT
LSLLEPETQDIPSSWTFPVASICGVSASKRDERCCFLYALPPAQDVQLCFPSVGHCQW
FCGLIQAWVTNPDSTAPAEEAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAGRDRH
TRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPG
GSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGL
LKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMA
TGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTLL
GDPFLQPGKRSRSPSSPRHAPRPSDAPSASPTPSANSTTQSQTFPCPQAPSQHPPSPP
KRCLSYGGTNQLRVPEEPAAEEPASPEESSGLSLLHQESKRRAMLAAVLEQELPALAE
NLHQEQKQEQGARLGRNHVEELLRCLGAHIHTPNRRQLAQELRALQGWMNGEDKGSF"
BASE COUNT 532 a 801 c 752 g 461 t
ORIGIN
1 tcatgaactt gctgctctcc taccgcgatg tgcaggacta ctcggccatc attgagctgg
61 tggagacgct gcaggccttg cccacctgtg atgtggccga gcagcataat gtctgcttcc
121 actacacttt tgccctcaac cggaggaaca ggcctgggga ccgggcgaag gccctgtctg
181 tgctgctgcc gctggtacag cttgagggct ctgtggcgcc cgatctgtac tgcatgtgtg
241 gccgtatcta caaggacatg ttcttcagct cgggtttcca ggatgctggg caccgggagc
301 aggcctatca ctggtatcgc aaggcttttg acgtagagcc cagccttcac tcaggcatca
361 atgcagctgt gctcctcatt gctgccgggc agcactttga ggattccaaa gagctccggc
421 taataggcat gaagctgggc tgcctgctgg cccgcaaagg ctgcgtggag aagatgcagt
481 attactggga tgtgggtttc tacctgggag cccagatcct cgccaatgac cccacccagg
541 tggtgctggc tgcagagcag ctgtataagc tcaatgcccc catatggtac ctggtgtccg
601 tgatggagac cttcctgctc taccagcact tcaggcccac gccagagccc cctggagggc
661 caccacgccg tgcccacttc tggctccact tcttgctaca gtcctgccaa ccattcaaga
721 cagcctgtgc ccagggcgac cagtgcttgg tgctggtcct ggagatgaac aaggtgctgc
781 tgcctgcaaa gctcgaggtt cggggtactg acccagtaag cacagtgacc ctgagcctgc
841 tggagcctga gacccaggac attccctcca gctggacctt cccagtcgcc tccatatgcg
901 gagtcagcgc ctcaaagcgc gacgagcgct gctgcttcct ctatgcactc cccccggctc
961 aggacgtcca gctgtgcttc cccagcgtag ggcactgcca gtggttctgc ggcctgatcc
1021 aggcctgggt gacgaacccg gattccacgg cgcccgcgga ggaggcggag ggcgcggggg
1081 agatgttgga gtttgattat gagtacacgg agacgggcga gcggctggtg ctgggcaagg
1141 gcacgtatgg ggtggtgtac gcgggccgcg atcgccacac gagggtgcgc atcgccatca
1201 aggagatccc ggagcgggac agcaggttct ctcagcccct gcatgaagag atcgctcttc
1261 acagacgcct gcgccacaag aacatagtgc gctatctggg ctcagctagc cagggcggct
1321 accttaagat cttcatggag gaagtgcctg gaggcagcct gtcctccttg ctgcggtcgg
1381 tgtggggacc cctgaaggac aacgagagca ccatcagttt ctacacccgc cagatcctgc
1441 agggacttgg ctacttgcac gacaaccaca tcgtgcacag ggacataaaa ggggacaatg
1501 tgctgatcaa caccttcagt gggctgctca agatttctga cttcggcacc tccaagcggc
1561 tggcaggcat cacaccttgc actgagacct tcacaggaac tctgcagtat atggccccag
1621 aaatcattga ccagggccca cgcgggtatg ggaaagcagc tgacatctgg tcactgggct
1681 gcactgtcat tgagatggcc acaggtcgcc cccccttcca cgagctcggg agcccacagg
1741 ctgccatgtt tcaggtgggt atgtacaagg tccatccgcc aatgcccagc tctctgtcgg
1801 ccgaggccca agcctttctc ctccgaactt ttgagccaga cccccgcctc cgagccagcg
1861 cccagacact gctgggggac cccttcctgc agcctgggaa aaggagccgc agccccagct
1921 ccccacgaca tgctccacgg ccctcagatg ccccttctgc cagtcccact ccttcagcca
1981 actcaaccac ccagtctcag acattcccgt gccctcaggc accctctcag cacccaccca
2041 gccccccgaa gcgctgcctc agttatgggg gcaccaacca gctccgggtg cccgaggagc
2101 ctgcggccga ggagcctgcg tctccggagg agagttcggg gctgagcctg ctgcaccagg
2161 agagcaagcg tcgggccatg ctggccgcag tattggagca ggagctgcca gcgctggcgg
2221 agaatctgca ccaggagcag aagcaagagc agggggcccg tctgggcaga aaccatgtgg
2281 aagagctgct gcgctgcctc ggggcacaca tccacactcc caaccgccgg cagctcgccc
2341 aggagctgcg ggcgctgcaa ggatggatga atggagagga caaaggcagc ttctgacaca
2401 ccagccccag gacctggggc gactggagga agccaggcga gtggggccca ggactggttc
2461 cagtgagaga aaccaaccac aggcacccaa gcactaccag acaaagcgta ttaaacagaa
2521 cacttttgaa aaaaaaaaaa aaaaaa
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