LOCUS BC015733 2308 bp mRNA linear HUM 02-MAR-2004
DEFINITION Homo sapiens CXXC finger 1 (PHD domain), mRNA (cDNA clone MGC:22977
IMAGE:4857493), complete cds.
ACCESSION BC015733
VERSION BC015733.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2308)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2308)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (09-OCT-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Steve Jones, Sarah Barber, Mabel Brown-John, Yaron Butterfield,
Andy Chan, Steve S. Chand, William Chow, Alison Cloutier, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Amara Masson, Mike R. Mayo, Josh Moran, Ryan Morin,
Teika Olson, Diana Palmquist, Anca Petrescu, Anna Liisa Prahbu,
Parvaneh Saeedi, JR Santos, Angelique Schnerch, Ursula Skalska,
Duane Smailus, Jeff Stott, Miranda Tsai, George Yang, Jacquie
Schein, Asim Siddiqui, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 34 Row: e Column: 17
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 7656974.
FEATURES Location/Qualifiers
source 1..2308
/db_xref="H-InvDB:HIT000037281"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:22977 IMAGE:4857493"
/tissue_type="Colon, adenocarcinoma"
/clone_lib="NIH_MGC_15"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..2308
/gene="CXXC1"
/gene_synonym="CGBP"
/gene_synonym="hCGBP"
/gene_synonym="HsT2645"
/gene_synonym="PCCX1"
/gene_synonym="PHF18"
/db_xref="GeneID:30827"
CDS 48..2030
/gene="CXXC1"
/gene_synonym="CGBP"
/gene_synonym="hCGBP"
/gene_synonym="HsT2645"
/gene_synonym="PCCX1"
/gene_synonym="PHF18"
/codon_start=1
/product="CXXC1 protein"
/protein_id="AAH15733.1"
/db_xref="GeneID:30827"
/translation="MEGDGSDPEPPDAGEDSKSENGENAPIYCICRKPDINCFMIGCD
NCNEWFHGDCIRITEKMAKAIREWYCRECREKDPKLEIRYRHKKSRERDGNERDSSEP
RDEGGGRKRPVPDPDLQRRAGSGTGVGAMLARGSASPHKSSPQPLVATPSQHHQQQQQ
QIKRSARMCGECEACRRTEDCGHCDFCRDMKKFGGPNKIRQKCRLRQCQLRARESYKY
FPSSLSPVTPSESLPRPRRPLPTQQQPQPSQKLGRIREDEGAVASSTVKEPPEATATP
EPLSDEDLPLDPDLYQDFCAGAFDDHGLPWMSDTEESPFLDPALRKRAVKVKHVKRRE
KKSEKKVMERKEERYKRHRQKQKHKDKWKHPERADAKDPASLPQCLGPGCVRPAQPSS
KYCSDDCGMKLAANRIYEILPQRIQQWQQSPCIAEEHGKKLLERIRREQQSARTRLQE
MERRFHELEAIILRAKQQAVREDEESNEGDSDDTDLQIFCVSCGHPINPRVALRHMER
CYAKYESQTSFGSMYPTRIEGATRLFCDVYNPQSKTYCKRLQVLCPEHSRDPKVPADE
VCGCPLVRDVFELTGDFCRLPKRQCNRHYCWEKLRRAEVDLERVRVWYKLDELFEQER
NVRTAMTNRAGLLALMLHQTIQHDPLTTDLRSSADR"
misc_feature 132..275
/gene="CXXC1"
/gene_synonym="CGBP"
/gene_synonym="hCGBP"
/gene_synonym="HsT2645"
/gene_synonym="PCCX1"
/gene_synonym="PHF18"
/note="PHD; Region: PHD-finger. PHD folds into an
interleaved type of Zn-finger chelating 2 Zn ions in a
similar manner to that of the RING and FYVE domains"
/db_xref="CDD:pfam00628"
misc_feature 534..641
/gene="CXXC1"
/gene_synonym="CGBP"
/gene_synonym="hCGBP"
/gene_synonym="HsT2645"
/gene_synonym="PCCX1"
/gene_synonym="PHF18"
/note="zf-CXXC; Region: CXXC zinc finger. This domain
contains eight conserved cysteine residues that bind to
zinc. The CXXC domain is found in proteins that methylate
cytosine, proteins that bind to methyl cytosine and HRX
related proteins"
/db_xref="CDD:pfam02008"
BASE COUNT 528 a 672 c 701 g 407 t
ORIGIN
1 gcgggtcgct ggcgggggtc gtgagggagt gcgccgggag cggagatatg gagggagatg
61 gttcagaccc agagcctcca gatgccgggg aggacagcaa gtccgagaat ggggagaatg
121 cgcccatcta ctgcatctgc cgcaaaccgg acatcaactg cttcatgatc gggtgtgaca
181 actgcaatga gtggttccat ggggactgca tccggatcac tgagaagatg gccaaggcca
241 tccgggagtg gtactgtcgg gagtgcagag agaaagaccc caagctagag attcgctatc
301 ggcacaagaa atcacgggag cgggatggca atgagcggga cagcagtgag ccccgggatg
361 agggtggagg gcgcaagagg cctgtccctg atccagacct gcagcgccgg gcagggtcag
421 ggacaggggt tggggccatg cttgctcggg gctctgcttc gccccacaaa tcctctccgc
481 agcccttggt ggccacaccc agccagcatc accagcagca gcagcagcag atcaaacggt
541 cagcccgcat gtgtggtgag tgtgaggcat gtcggcgcac tgaggactgt ggtcactgtg
601 atttctgtcg ggacatgaag aagttcgggg gccccaacaa gatccggcag aagtgccggc
661 tgcgccagtg ccagctgcgg gcccgggaat cgtacaagta cttcccttcc tcgctctcac
721 cagtgacgcc ctcagagtcc ctgccaaggc cccgccggcc actgcccacc caacagcagc
781 cacagccatc acagaagtta gggcgcatcc gtgaagatga gggggcagtg gcgtcatcaa
841 cagtcaagga gcctcctgag gctacagcca cacctgagcc actctcagat gaggacctac
901 ctctggatcc tgacctgtat caggacttct gtgcaggggc ctttgatgac catggcctgc
961 cctggatgag cgacacagaa gagtccccat tcctggaccc cgcgctgcgg aagagggcag
1021 tgaaagtgaa gcatgtgaag cgtcgggaga agaagtctga gaagaaggtg atggagagga
1081 aggaggagcg atacaagcgg catcggcaga agcagaagca caaggataaa tggaaacacc
1141 cagagagggc tgatgccaag gaccctgcgt cactgcccca gtgcctgggg cccggctgtg
1201 tgcgccccgc ccagcccagc tccaagtatt gctcagatga ctgtggcatg aagctggcag
1261 ccaaccgcat ctacgagatc ctcccccagc gcatccagca gtggcagcag agcccttgca
1321 ttgctgaaga gcacggcaag aagctgctcg aacgcattcg ccgagagcag cagagtgccc
1381 gcacccgcct tcaggaaatg gaacgccgat tccatgagct tgaggccatc attctacgtg
1441 ccaagcagca ggctgtgcgc gaggatgagg agagcaacga gggtgacagt gatgacacag
1501 acctgcagat cttctgtgtt tcctgtgggc accccatcaa cccacgtgtt gccttgcgcc
1561 acatggagcg ctgctacgcc aagtatgaga gccagacgtc ctttgggtcc atgtacccca
1621 cacgcattga aggggccaca cgactcttct gtgatgtgta taatcctcag agcaaaacat
1681 actgtaagcg gctccaggtg ctgtgccccg agcactcacg ggaccccaaa gtgccagctg
1741 acgaggtatg cgggtgcccc cttgtacgtg atgtctttga gctcacgggt gacttctgcc
1801 gcctgcccaa gcgccagtgc aatcgccatt actgctggga gaagctgcgg cgtgcggaag
1861 tggacttgga gcgcgtgcgt gtgtggtaca agctggacga gctgtttgag caggagcgca
1921 atgtgcgcac agccatgaca aaccgcgcgg gattgctggc cctgatgctg caccagacga
1981 tccagcacga tcccctcact accgacctgc gctccagtgc cgaccgctga gcctcctggc
2041 ccggacccct tacaccctgc attccagatg ggggagccgc ccggtgcccg tgtgtccgtt
2101 cctccactca tctgtttctc cggttctccc tgtgcccatc caccggttga ccgcccatct
2161 gcctttatca gagggactgt ccccgtcgac atgttcagtg cctggtgggg ctgcggagtc
2221 cactcatcct tgcctcctct ccctgggttt tgttaataaa attttgaaga acccaaaaaa
2281 aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//