LOCUS BC014631 4176 bp mRNA linear HUM 12-NOV-2003
DEFINITION Homo sapiens fatty acid synthase, mRNA (cDNA clone IMAGE:3351370),
partial cds.
ACCESSION BC014631
VERSION BC014631.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4176)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4176)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (24-SEP-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Nov 6, 2003 this sequence version replaced BC014631.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Institute for Systems Biology
http://www.systemsbiology.org
contact: amadan@systemsbiology.org
Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha
Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 11 Row: m Column: 1
This clone was selected for full length sequencing because it
passed the following selection criteria: Hexamer frequency ORF
analysis.
FEATURES Location/Qualifiers
source 1..4176
/db_xref="H-InvDB:HIT000088457"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:3351370"
/tissue_type="Eye, retinoblastoma"
/clone_lib="NIH_MGC_16"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene <1..4176
/gene="FASN"
/gene_synonym="FAS"
/gene_synonym="MGC14367"
/gene_synonym="MGC15706"
/gene_synonym="OA-519"
/db_xref="GeneID:2194"
/db_xref="MIM:600212"
CDS <1..2326
/gene="FASN"
/gene_synonym="FAS"
/gene_synonym="MGC14367"
/gene_synonym="MGC15706"
/gene_synonym="OA-519"
/codon_start=2
/product="FASN protein"
/protein_id="AAH14631.1"
/db_xref="GeneID:2194"
/db_xref="MIM:600212"
/translation="SGLHTESAPRRQQEQQVPILEKFCFTPHTEEGCLSERAALQEEL
QLCKGLVQALQTKVTQQGLKMVVPGLDGAQIPRDPSQQELPRLLSAACRLQLNGNLQL
ELAQVLAQERPKLPEDPLLSGLLDSPALKACLDTAVENMPSLKMKVVEVLAGHGHLYS
RIPGLLSPHPLLQLSYTATDRHPQALEAAQAELQQHDVAQGQWDPADPAPSALGSADL
LVCNCAVAALGDPASALSNMVAALREGGFLLLHTLLRGHPLGDIVAFLTSTEPQYGQG
ILSQDAWESLFSRVSLRLVGLKKSFYGSTLFLCRRPTPQDSPIFLPVDDTSFRWVESL
KGILADEDSSRPVWLKAINCATSGVVGLVNCLRREPGGNRLRCVLLSNLSSTSHVPEV
DPGSAELQKVLQGDLVMNVYRDGAWGAFRHFLLEEDKPEEPTAHAFVSTLTRGDLSSI
RWVCSSLRHAQPTCPGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWTSQDSLLGME
FSGRDASGKRVMGLVPAKGLATSVLLSPDFLWDVPSNWTLEEAASVPVVYSTAYYALV
VRGRVRPGETLLIHSGSGGVGQAAIAIALSLGCRVFTTVGSAEKRAYLQARFPQLDST
SFANSRDTSFEQHVLWHTGGKGVDLVLNSLAEEKLQASVRCLATHGRFLEIGKFDLSQ
NHPLGMAIFLKNVTFHGVLLDAFFNESSADWREVWALVQAGIRDGVVRPLKCTVFHGA
QVEDAFRYMAQGKASQAWPCSGAPSATWAFWWRR"
misc_feature 1328..2266
/gene="FASN"
/gene_synonym="FAS"
/gene_synonym="MGC14367"
/gene_synonym="MGC15706"
/gene_synonym="OA-519"
/note="ADH_zinc_N; Region: Zinc-binding dehydrogenase"
/db_xref="CDD:pfam00107"
BASE COUNT 702 a 1419 c 1319 g 736 t
ORIGIN
1 ctccgggctc cacactgagt cggccccgcg gcggcagcag gagcagcagg tgcccatcct
61 ggagaagttt tgcttcactc cccacacgga ggaggggtgc ctgtctgagc gcgctgccct
121 gcaggaggag ctgcaactgt gcaaggggct ggtgcaggca ctgcagacca aggtgaccca
181 gcaggggctg aagatggtgg tgcccggact ggatggggcc cagatccccc gggacccctc
241 acagcaggaa ctgccccggc tgttgtcggc tgcctgcagg cttcagctca acgggaacct
301 gcagctggag ctggcgcagg tgctggccca ggagaggccc aagctgccag aggaccctct
361 gctcagcggc ctcctggact ccccggcact caaggcctgc ctggacactg ccgtggagaa
421 catgcccagc ctgaagatga aggtggtgga ggtgctggct ggccacggtc acctgtattc
481 ccgcatccca ggcctgctca gcccccatcc cctgctgcag ctgagctaca cggccaccga
541 ccgccacccc caggccctgg aggctgccca ggccgagctg cagcagcacg acgttgccca
601 gggccagtgg gatcccgcag accctgcccc cagcgccctg ggcagcgccg acctcctggt
661 gtgcaactgt gctgtggctg ccctcgggga cccggcctca gctctcagca acatggtggc
721 tgccctgaga gaagggggct ttctgctcct gcacacactg ctccgggggc accccctcgg
781 ggacatcgtg gccttcctca cctccactga gccgcagtat ggccagggca tcctgagcca
841 ggacgcgtgg gagagcctct tctccagggt gtcgctgcgc ctggtgggcc tgaagaagtc
901 cttctacggc tccacgctct tcctgtgccg ccggcccacc ccgcaggaca gccccatctt
961 cctgccggtg gacgatacca gcttccgctg ggtggagtct ctgaagggca tcctggctga
1021 cgaagactct tcccggcctg tgtggctgaa ggccatcaac tgtgccacct cgggcgtggt
1081 gggcttggtg aactgtctcc gccgagagcc cggcgggaac cgcctccggt gtgtgctgct
1141 ctccaacctc agcagcacct cccacgtccc ggaggtggac ccgggctccg cagaactgca
1201 gaaggtgttg cagggagacc tggtgatgaa cgtctaccgc gacggggcct ggggggcttt
1261 ccgccacttc ctgctggagg aggacaagcc tgaggagccg acggcacatg cctttgtgag
1321 caccctcacc cggggggacc tgtcctccat ccgctgggtc tgctcctcgc tgcgccatgc
1381 ccagcccacc tgccctggcg cccagctctg cacggtctac tacgcctccc tcaacttccg
1441 cgacatcatg ctggccactg gcaagctgtc ccctgatgcc atcccaggga agtggacctc
1501 ccaggacagc ctgctaggta tggagttctc gggccgagac gccagcggca agcgtgtgat
1561 gggactggtg cctgccaagg gcctggccac ctctgtcctg ctgtcaccgg acttcctctg
1621 ggatgtgcct tccaactgga cgctggagga ggcggcctcg gtgcctgtcg tctacagcac
1681 ggcctactac gcgctggtgg tgcgtgggcg ggtgcgcccc ggggagacgc tgctcatcca
1741 ctcgggctcg ggcggcgtgg gccaggccgc catcgccatc gccctcagtc tgggctgccg
1801 cgtcttcacc accgtggggt cggctgagaa gcgggcgtac ctccaggcca ggttccccca
1861 gctcgacagc accagcttcg ccaactcccg ggacacatcc ttcgagcagc atgtgctgtg
1921 gcacacgggc gggaagggcg ttgacctggt cttgaactcc ttggcggaag agaagctgca
1981 ggccagcgtg aggtgcttgg ctacgcacgg tcgcttcctg gaaattggca aattcgacct
2041 ttctcagaac cacccgctcg gcatggctat cttcctgaag aacgtgacat tccacggggt
2101 cctactggat gcgttcttca acgagagcag tgctgactgg cgggaggtgt gggcgcttgt
2161 gcaggccggc atccgggatg gggtggtacg gcccctcaag tgcacggtgt tccatggggc
2221 ccaggtggag gacgccttcc gctacatggc ccaagggaag gcctcccagg cctggccgtg
2281 cagtggggcg ccatcggcga cgtgggcatt ttggtggaga cgatgagcac caacgacacg
2341 atcgtcagtg gcacgctgcc ccagcgcatg gcgtcctgcc tggaggtgct ggacctcttc
2401 ctgaaccagc cccacatggt cctgagcagc tttgtgctgg ctgagaaggc tgcggcctat
2461 agggacaggg acagccagcg ggacctggtg gaggccgtgg cacacatcct gggcatccgc
2521 gacttggctg ctgtcaacct ggacagctca ctggcggacc tgggcctgga ctcgctcatg
2581 agcgtggagg tgcgccagac gctggagcgt gagctcaacc tggtgctgtc cgtgcgcgag
2641 gtgcggcaac tcacgctccg gaaactgcag gagctgtcct caaaggcgga tgaggccagc
2701 gagctggcat gccccacgcc caaggaggat ggtctggccc agcagcagac tcagctgaac
2761 ctgcgctccc tgctggtgaa cccggagggc cccaccctga tgcggctcaa ctccgtgcag
2821 agctcggagc ggcccctgtt cctggtgcac ccaatcgagg gctccaccac cgtgttccac
2881 agcctggcct cccggctcag catccccacc tatggcctgc agtgcacccg agctgcgccc
2941 cttgacagca tccacagcct ggctgcctac tacatcgact gcatcaggca ggtgcagccc
3001 gagggcccct accgcgtggc cggctactcc tacggggcct gcgtggcctt tgaaatgtgc
3061 tcccagctgc aggcccagca gagcccagcc cccacccaca acagcctctt cctgttcgac
3121 ggctcgccca cctacgtact ggcctacacc cagagctacc gggcaaagct gaccccaggc
3181 tgtgaggctg aggctgagac ggaggccata tgcttcttcg tgcagcagtt cacggacatg
3241 gagcacaaca gggtgctgga ggcgctgctg ccgctgaagg gcctagagga gcgtgtggca
3301 gccgccgtgg acctgatcat caagagccac cagggcctgg accgccagga gctgagcttt
3361 gcggcccggt ccttctacta caagctgcgt gccgctgagc agtacacacc caaggccaag
3421 taccatggca acgtgatgct actgcgcgcc aagacgggtg gcgcctacgg cgaggacctg
3481 ggcgcggact acaacctctc ccaggtatgc gacgggaaag tatccgtcca cgtcatcgag
3541 ggtgaccacc gcacgctgct ggagggcagc ggcctggagt ccatcatcag catcatccac
3601 agctccctgg ctgagccacg cgtgagcgtg cgggagggct aggcccgtgc ccccgcctgc
3661 caccggaggt cactccacca tccccacccc accccacccc acccccgcca tgcaacggga
3721 ttgaagggtc ctgccggtgg gaccctgtcc ggcccagtgc cactgccccc cgaggctgct
3781 agatgtaggt gttaggcatg tcccacccac ccgccgcctc ccacggcacc tcggggacac
3841 cagagctgcc gacttggaga ctcctggtct gtgaagagcc ggtggtgccc gtgcccgcag
3901 gaactgggct gggcctcgtg cgcccgtggg gtctgcgctt ggtctttctg tgcttggatt
3961 tgcatattta ttgcattgct ggtagagacc cccaggcctg tccaccctgc caagactcct
4021 caggcagcgt gtgggtcccg cactctgccc ccatttcccc atttccccgt ggggtgctgc
4081 ccttatgccc ggcgccgggc accaactcca tgtttggtgt ttgtctgtgt ttgtttttca
4141 agaaatgatt caaattgcaa aaaaaaaaaa aaaaaa
//