LOCUS BC014507 2407 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens lamin A/C, mRNA (cDNA clone MGC:23638 IMAGE:4863480),
complete cds.
ACCESSION BC014507
VERSION BC014507.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2407)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2407)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (17-SEP-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC/DCTD/DTP
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 34 Row: h Column: 7
This clone was selected for full length sequencing because it
passed the following selection criteria: Hexamer frequency ORF
analysis.
FEATURES Location/Qualifiers
source 1..2407
/db_xref="H-InvDB:HIT000088423"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:23638 IMAGE:4863480"
/tissue_type="Skin, melanotic melanoma, high MDR."
/clone_lib="NIH_MGC_49"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..2407
/gene="LMNA"
/gene_synonym="CDCD1"
/gene_synonym="CDDC"
/gene_synonym="CMT2B1"
/gene_synonym="EMD2"
/gene_synonym="FPL"
/gene_synonym="FPLD"
/gene_synonym="HGPS"
/gene_synonym="IDC"
/gene_synonym="LDP1"
/gene_synonym="LFP"
/gene_synonym="LGMD1B"
/gene_synonym="LMNC"
/gene_synonym="PRO1"
/db_xref="GeneID:4000"
/db_xref="HGNC:HGNC:6636"
/db_xref="MIM:150330"
CDS 198..2192
/gene="LMNA"
/gene_synonym="CDCD1"
/gene_synonym="CDDC"
/gene_synonym="CMT2B1"
/gene_synonym="EMD2"
/gene_synonym="FPL"
/gene_synonym="FPLD"
/gene_synonym="HGPS"
/gene_synonym="IDC"
/gene_synonym="LDP1"
/gene_synonym="LFP"
/gene_synonym="LGMD1B"
/gene_synonym="LMNC"
/gene_synonym="PRO1"
/codon_start=1
/product="lamin A/C"
/protein_id="AAH14507.1"
/db_xref="GeneID:4000"
/db_xref="HGNC:HGNC:6636"
/db_xref="MIM:150330"
/translation="METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAV
YIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARL
QLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEG
ELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRET
KRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQ
SAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTS
RRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPS
PTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTSGRVAVEEVDEEGK
FVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSP
PTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTVVEDDEDEDGDDLLHHHH
GSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASASGSGAQVGGPISSGSSASSVTVTR
SYRSVGGSGGGSFGDNLVTRSYLLGNSSPRTQSPQNCSIM"
BASE COUNT 529 a 728 c 776 g 374 t
ORIGIN
1 gagcgccgca cctacaccag ccaacccaga tcccgaggtc cgacagcgcc cggcccagat
61 ccccacgcct gccaggagca agccgagagc cagccggccg gcgcactccg actccgagca
121 gtctctgtcc ttcgacccga gccccgcgcc ctttccggga cccctgcccc gcgggcagcg
181 ctgccaacct gccggccatg gagaccccgt cccagcggcg cgccacccgc agcggggcgc
241 aggccagctc cactccgctg tcgcccaccc gcatcacccg gctgcaggag aaggaggacc
301 tgcaggagct caatgatcgc ttggcggtct acatcgaccg tgtgcgctcg ctggaaacgg
361 agaacgcagg gctgcgcctt cgcatcaccg agtctgaaga ggtggtcagc cgcgaggtgt
421 ccggcatcaa ggccgcctac gaggccgagc tcggggatgc ccgcaagacc cttgactcag
481 tagccaagga gcgcgcccgc ctgcagctgg agctgagcaa agtgcgtgag gagtttaagg
541 agctgaaagc gcgcaatacc aagaaggagg gtgacctgat agctgctcag gctcggctga
601 aggacctgga ggctctgctg aactccaagg aggccgcact gagcactgct ctcagtgaga
661 agcgcacgct ggagggcgag ctgcatgatc tgcggggcca ggtggccaag cttgaggcag
721 ccctaggtga ggccaagaag caacttcagg atgagatgct gcggcgggtg gatgctgaga
781 acaggctgca gaccatgaag gaggaactgg acttccagaa gaacatctac agtgaggagc
841 tgcgtgagac caagcgccgt catgagaccc gactggtgga gattgacaat gggaagcagc
901 gtgagtttga gagccggctg gcggatgcgc tgcaggaact gcgggcccag catgaggacc
961 aggtggagca gtataagaag gagctggaga agacttattc tgccaagctg gacaatgcca
1021 ggcagtctgc tgagaggaac agcaacctgg tgggggctgc ccacgaggag ctgcagcagt
1081 cgcgcatccg catcgacagc ctctctgccc agctcagcca gctccagaag cagctggcag
1141 ccaaggaggc gaagcttcga gacctggagg actcactggc ccgtgagcgg gacaccagcc
1201 ggcggctgct ggcggaaaag gagcgggaga tggccgagat gcgggcaagg atgcagcagc
1261 agctggacga gtaccaggag cttctggaca tcaagctggc cctggacatg gagatccacg
1321 cctaccgcaa gctcttggag ggcgaggagg agaggctacg cctgtccccc agccctacct
1381 cgcagcgcag ccgtggccgt gcttcctctc actcatccca gacacagggt gggggcagcg
1441 tcaccaaaaa gcgcaaactg gagtccactg agagccgcag cagcttctca cagcacgcac
1501 gcactagcgg gcgcgtggcc gtggaggagg tggatgagga gggcaagttt gtccggctgc
1561 gcaacaagtc caatgaggac cagtccatgg gcaattggca gatcaagcgc cagaatggag
1621 atgatccctt gctgacttac cggttcccac caaagttcac cctgaaggct gggcaggtgg
1681 tgacgatctg ggctgcagga gctggggcca cccacagccc ccctaccgac ctggtgtgga
1741 aggcacagaa cacctggggc tgcgggaaca gcctgcgtac ggctctcatc aactccactg
1801 gggaagaagt ggccatgcgc aagctggtgc gctcagtgac tgtggttgag gacgacgagg
1861 atgaggatgg agatgacctg ctccatcacc accacggctc ccactgcagc agctcggggg
1921 accccgctga gtacaacctg cgctcgcgca ccgtgctgtg cgggacctgc gggcagcctg
1981 ccgacaaggc atctgccagc ggctcaggag cccaggtggg cggacccatc tcctctggct
2041 cttctgcctc cagtgtcacg gtcactcgca gctaccgcag tgtggggggc agtgggggtg
2101 gcagcttcgg ggacaatctg gtcacccgct cctacctcct gggcaactcc agcccccgaa
2161 cccagagccc ccagaactgc agcatcatgt aatctgggac ctgccaggca ggggtggggg
2221 tggaggcttc ctgcgtcctc ctcacctcat gcccaccccc tgccctgcac gtcatgggag
2281 ggggcttgaa gccaaagaaa aataaccctt tggttttttt cttctgtatt tttttttcta
2341 agagaagtta ttttctacag tggttttata ctgaaggaaa aacacaagca aaaaaaaaaa
2401 aaaaaaa
//