LOCUS BC014243 4224 bp mRNA linear HUM 15-JUL-2006 DEFINITION Homo sapiens tyrosine kinase 2, mRNA (cDNA clone MGC:20776 IMAGE:4591726), complete cds. ACCESSION BC014243 VERSION BC014243.2 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4224) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. CONSRTM Mammalian Gene Collection Program Team TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 4224) CONSRTM NIH MGC Project TITLE Direct Submission JOURNAL Submitted (10-SEP-2001) National Institutes of Health, Mammalian Gene Collection (MGC), Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT On Aug 19, 2003 this sequence version replaced BC014243.1. Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: DCTD/DTP cDNA Library Preparation: Rubin Laboratory cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: National Institutes of Health Intramural Sequencing Center (NISC), Gaithersburg, Maryland; Web site: http://www.nisc.nih.gov/ Contact: nisc_mgc@nhgri.nih.gov Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B., Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S., Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P., Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R., Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C., McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W., Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L., Young,A., Zhang,L.-H. and Green,E.D. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAL Plate: 30 Row: l Column: 8 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi: 34222294. FEATURES Location/Qualifiers source 1..4224 /db_xref="H-InvDB:HIT000036596" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:20776 IMAGE:4591726" /tissue_type="Kidney, renal cell adenocarcinoma" /clone_lib="NIH_MGC_14" /lab_host="DH10B-R" /note="Vector: pOTB7" gene 1..4224 /gene="TYK2" /gene_synonym="JTK1" /db_xref="GeneID:7297" /db_xref="HGNC:HGNC:12440" /db_xref="MIM:176941" CDS 342..3905 /gene="TYK2" /gene_synonym="JTK1" /codon_start=1 /product="tyrosine kinase 2" /protein_id="AAH14243.1" /db_xref="GeneID:7297" /db_xref="HGNC:HGNC:12440" /db_xref="MIM:176941" /translation="MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWV TFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLY FRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEF VNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRS FRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVP VCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVN KEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHC VSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDG IHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIE QQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRG ARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDE DPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPE NIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNI LLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKW GFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQR PSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLY CYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEK SLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHSQHYIHRDLAARNVL LDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFG VTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYH LMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC" BASE COUNT 852 a 1298 c 1279 g 795 t ORIGIN 1 gttcgagctt gtgttccccc ggaagggtga gtctggacgc gggcgcggaa ggagcgcggc 61 cggaggtcct caggaagaag ccgcggggac tggctgcgct tgacaggctg cacttggatg 121 ggagcacctg gtgcctcggg actgctccga tgcccgggtc tgtgctgaat gtgtaatatg 181 cggaactata ttgaaacatt acaaccatct tttgatggca acaccctgag gacctccctt 241 ttccagatgg ggaaactgag gcccagaatt gctaagtggc ttgcttgagt tgacacaggg 301 agctccagga ctcaccctca gctgagccac ctgccgggag catgcctctg cgccactggg 361 ggatggccag gggcagtaag cccgttgggg atggagccca gcccatggct gccatgggag 421 gcctgaaggt gcttctgcac tgggctggtc caggcggcgg ggagccctgg gtcactttca 481 gtgagtcatc gctgacagct gaggaagtct gcatccacat tgcacataaa gttggtatca 541 ctcctccttg cttcaatctc tttgccctct tcgatgctca ggcccaagtc tggttgcccc 601 caaaccacat cctagagatc cccagagatg caagcctgat gctatatttc cgcataaggt 661 tttatttccg gaactggcat ggcatgaatc ctcgggaacc ggctgtgtac cgttgtgggc 721 ccccaggaac cgaggcatcc tcagatcaga cagcacaggg gatgcaactc ctggacccag 781 cctcatttga gtacctcttt gagcagggca agcatgagtt tgtgaatgac gtggcatcac 841 tgtgggagct gtcgaccgag gaggagatcc accactttaa gaatgagagc ctgggcatgg 901 cctttctgca cctctgtcac ctcgctctcc gccatggcat ccccctggag gaggtggcca 961 agaagaccag cttcaaggac tgcatcccgc gctccttccg ccggcatatc cggcagcaca 1021 gcgccctgac ccggctgcgc cttcggaacg tcttccgcag gttcctgcgg gacttccagc 1081 cgggccgact ctcccagcag atggtcatgg tcaaatacct agccacactc gagcggctgg 1141 caccccgctt cggcacagag cgtgtgcccg tgtgccacct gaggctgctg gcccaggccg 1201 agggggagcc ctgctacatc cgggacagtg gggtggcccc tacagaccct ggccctgagt 1261 ctgctgctgg gcccccaacc cacgaggtgc tggtgacagg cactggtggc atccagtggt 1321 ggccagtaga ggaggaggtg aacaaggagg agggttctag tggcagcagt ggcaggaacc 1381 cccaagccag cctgtttggg aagaaggcca aggctcacaa ggcagtcggc cagccggcag 1441 acaggccgcg ggagccactg tgggcctact tctgtgactt ccgggacatc acccacgtgg 1501 tgctgaaaga gcactgtgtc agcatccacc ggcaggacaa caagtgcctg gagctgagct 1561 tgccttcccg ggctgcggcg ctgtccttcg tgtcgctggt ggacggctat ttccgcctga 1621 cggccgactc cagccactac ctgtgccacg aggtggctcc cccacggctg gtgatgagca 1681 tccgggatgg gatccacgga cccctgctgg agccatttgt gcaggccaag ctgcggcccg 1741 aggacggcct gtacctcatt cactggagca ccagccaccc ctaccgcctg atcctcacag 1801 tggcccagcg tagccaggca ccagacggca tgcagagctt gcggctccga aagttcccca 1861 ttgagcagca ggacggggcc ttcgtgctgg agggctgggg ccggtccttc cccagcgttc 1921 gggaacttgg ggctgccttg cagggctgct tgctgagggc cggggatgac tgcttctctc 1981 tgcgtcgctg ttgcctgccc caaccaggag aaacctccaa tctcatcatc atgcgggggg 2041 ctcgggccag ccccaggaca ctcaacctca gccagctcag cttccaccgg gttgaccaga 2101 aggagatcac ccagctgtcc cacttgggcc agggcacaag gaccaacgtg tatgagggcc 2161 gcctgcgagt ggagggcagc ggggaccctg aggagggcaa gatggatgac gaggaccccc 2221 tcgtgcctgg cagggaccgt gggcaggagc tacgagtggt gctcaaagtg ctggacccta 2281 gtcaccatga catcgccctg gccttctacg agacagccag cctcatgagc caggtctccc 2341 acacgcacct ggccttcgtg catggcgtct gtgtgcgcgg ccctgaaaat atcatggtga 2401 cagagtacgt ggagcacgga cccctggatg tgtggctgcg gagggagcgg ggccatgtgc 2461 ccatggcttg gaagatggtg gtggcccagc agctggccag cgccctcagc tacctggaga 2521 acaagaacct ggttcatggt aatgtgtgtg gccggaacat cctgctggcc cggctggggt 2581 tggcagaggg caccagcccc ttcatcaagc tgagtgatcc tggcgtgggc ctgggcgccc 2641 tctccaggga ggagcgggtg gagaggatcc cctggctggc ccccgaatgc ctaccaggtg 2701 gggccaacag cctaagcacc gccatggaca agtgggggtt tggcgccacc ctcctggaga 2761 tctgctttga cggagaggcc cctctgcaga gccgcagtcc ctccgagaag gagcatttct 2821 accagaggca gcaccggctg cccgagccct cctgcccaca gctggccaca ctcaccagcc 2881 agtgtctgac ctatgagcca acccagaggc catcattccg caccatcctg cgtgacctca 2941 cccggctgca gccccacaat cttgctgacg tcttgactgt gaacccggac tcaccggcgt 3001 cggaccctac ggttttccac aagcgctatt tgaaaaagat ccgagatctg ggcgagggtc 3061 acttcggcaa ggtcagcttg tactgctacg atccgaccaa cgacggcact ggcgagatgg 3121 tggcggtgaa agccctcaag gcagactgcg gcccccagca ccgctcgggc tggaagcagg 3181 agattgacat tctgcgcacg ctctaccacg agcacatcat caagtacaag ggctgctgcg 3241 aggaccaagg cgagaagtcg ctgcagctgg tcatggagta cgtgcccctg ggcagcctcc 3301 gagactacct gccccggcac agcatcgggc tggcccagct gctgctcttc gcccagcaga 3361 tctgcgaggg catggcctat ctgcactcgc agcactacat ccaccgagac ctagccgcgc 3421 gcaacgtgct gctggacaac gacaggctgg tcaagatcgg ggactttggc ctagccaagg 3481 ccgtgcccga aggccacgag tactaccgcg tgcgcgagga tggggacagc cccgtgttct 3541 ggtatgcccc agagtgcctg aaggagtata agttctacta tgcgtcagat gtctggtcct 3601 tcggggtgac cctgtatgag ctgctgacgc actgtgactc cagccagagc ccccccacga 3661 aattccttga gctcataggc attgctcagg gtcagatgac agttctgaga ctcactgagt 3721 tgctggaacg aggggagagg ctgccacggc ccgacaaatg tccctgtgag gtctatcatc 3781 tcatgaagaa ctgctgggag acagaggcgt cctttcgccc aaccttcgag aacctcatac 3841 ccattctgaa gacagtccat gagaagtacc aaggccaggc cccttcagtg ttcagcgtgt 3901 gctgaggcac aatggcagcc ctgcctggga ggactggacc aggcagtggc tgcagaggga 3961 gcctcctgct ccctgctcca ggatgaaacc aagaggggga tgtcagcctc acccacaccg 4021 tgtgccttac tcctgtctag agaccccacc tctgtgaact tatttttctt tcttggccgt 4081 gagcctaacc atgatcttga gggacccaac atttgtaggg gcactaatcc agcccttaaa 4141 tcccccagct tccaaacttg aggcccacca tctccaccat ctggtaataa actcatgttt 4201 tctctgaaaa aaaaaaaaaa aaaa //