LOCUS BC014214 3103 bp mRNA linear HUM 08-OCT-2003
DEFINITION Homo sapiens adaptor-related protein complex 2, alpha 1 subunit,
mRNA (cDNA clone MGC:20679 IMAGE:4111165), complete cds.
ACCESSION BC014214
VERSION BC014214.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3103)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3103)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (10-SEP-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Aug 20, 2003 this sequence version replaced BC014214.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 30 Row: b Column: 4
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 19913415.
FEATURES Location/Qualifiers
source 1..3103
/db_xref="H-InvDB:HIT000036581"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:20679 IMAGE:4111165"
/tissue_type="Muscle, rhabdomyosarcoma"
/clone_lib="NIH_MGC_17"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..3103
/gene="AP2A1"
/gene_synonym="ADTAA"
/gene_synonym="AP2-ALPHA"
/gene_synonym="CLAPA1"
/db_xref="GeneID:160"
/db_xref="MIM:601026"
CDS 110..3058
/gene="AP2A1"
/gene_synonym="ADTAA"
/gene_synonym="AP2-ALPHA"
/gene_synonym="CLAPA1"
/codon_start=1
/product="AP2A1 protein"
/protein_id="AAH14214.1"
/db_xref="GeneID:160"
/db_xref="MIM:601026"
/translation="MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKF
KGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYTEKQIGYLFISVLV
NSNSELIRLINNAIKNDLASRNPTFMCLALHCIANVGSREMGEAFAADIPRILVAGDS
MDSVKQSAALCLLRLYKASPDLVPMGEWTARVVHLLNDQHMGVVTAAVSLITCLCKKN
PDDFKTCVSLAVSRLSRIVSSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPLPEDAAV
KGRLVECLETVLNKAQEPPKSKKVQHSNAKNAILFETISLIIHYDSEPNLLVRACNQL
GQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIDTVINALKTERDVSVRQRAADL
LYAMCDRSNAKQIVSEMLRYLETADYAIREEIVLKVAILAEKYAVDYSWYVDTILNLI
RIAGDYVSEEVWYRVLQIVTNRDDVQGYAAKTVFEALQAPACHENMVKVGGYILGEFG
NLIAGDPRSSPPVQFSLLHSKFHLCSVATRALLLSTYIKFINLFPETKATIQGVLRAG
SQLRNADVELQQRAVEYLTLSSVASTDVLATVLEEMPPFPERESSILAKLKRKKGPGA
GSALDDGRRDPSSNDINGGMEPTPSTVSTPSPSADLLGLRAAPPPAAPPASAGAGNLL
VDVFDGPAAQPSLGPTPEEAFLSPGPEDIGPPIPEADELLNKFVCKNNGVLFENQLLQ
IGVKSEFRQNLGRMYLFYGNKTSVQFQNFSPTVVHPGDLQTQLAVQTKRVAAQVDGGA
QVQQVLNIECLRDFLTPPLLSVRFRYGGAPQALTLKLPVTINKFFQPTEMAAQDFFQR
WKQLSLPQQEAQKIFKANHPMDAEVTKAKLLGFGSALLDNVDPNPGDREDTRVWGMPG
TFLRPFVFLFLFICCCLHSGGLGGVPLPPFPPQAQRGEGPGKWMSPPLPPHPVVAPPT
PSPSRGCVLL"
misc_feature 194..1882
/gene="AP2A1"
/gene_synonym="ADTAA"
/gene_synonym="AP2-ALPHA"
/gene_synonym="CLAPA1"
/note="Adaptin_N; Region: Adaptin N terminal region. This
family consists of the N terminal region of various alpha,
beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor
protein complexes. The adaptor protein (AP) complexes are
involved in the formation of clathrin-coated pits and
vesicles. The N-terminal region of the various adaptor
proteins (APs) is constant by comparison to the C-terminal
which is variable within members of the AP-2 family"
/db_xref="CDD:pfam01602"
misc_feature 2279..2584
/gene="AP2A1"
/gene_synonym="ADTAA"
/gene_synonym="AP2-ALPHA"
/gene_synonym="CLAPA1"
/note="Alpha_adaptinC2; Region: pfam02883,
Alpha_adaptinC2, Adaptin C-terminal domain. Alpha adaptin
is a heterotetramer which regulates clathrin-bud
formation. The carboxyl-terminal appendage of the alpha
subunit regulates translocation of endocytic accessory
proteins to the bud site. This ig-fold domain is found in
alpha, beta and gamma adaptins"
/db_xref="CDD:pfam02883"
misc_feature 2633..2818
/gene="AP2A1"
/gene_synonym="ADTAA"
/gene_synonym="AP2-ALPHA"
/gene_synonym="CLAPA1"
/note="Alpha_adaptin_C; Region: Alpha adaptin AP2,
C-terminal domain. Alpha adaptin is a hetero tetramer
which regulates clathrin-bud formation. The
carboxyl-terminal appendage of the alpha subunit regulates
translocation of endocytic accessory proteins to the bud
site"
/db_xref="CDD:pfam02296"
BASE COUNT 627 a 1009 c 881 g 586 t
ORIGIN
1 gctcggctcc ttggcgctgc ctggggtcct ttccgcccgg tccccgcttg ccagcccccg
61 ctgctctgtg ccctgtccgg ccaggcctgg agccgacacc accgccatca tgccggccgt
121 gtccaagggc gatgggatgc gggggctcgc ggtgttcatc tccgacatcc ggaactgtaa
181 gagcaaagag gcggaaatta agagaatcaa caaggaactg gccaacatcc gctccaagtt
241 caaaggagac aaagccttgg atggctacag taagaaaaaa tatgtgtgta aactgctttt
301 catcttcctg cttggccatg acattgactt tgggcacatg gaggctgtga atctgttgag
361 ttccaataaa tacacagaga agcaaatagg ttacctgttc atttctgtgc tggtgaactc
421 gaactcggag ctgatccgcc tcatcaacaa cgccatcaag aatgacctgg ccagccgcaa
481 ccccaccttc atgtgcctgg ccctgcactg catcgccaac gtgggcagcc gggagatggg
541 cgaggccttt gccgctgaca tcccccgcat cctggtggcc ggggacagca tggacagtgt
601 caagcagagt gcggccctgt gcctccttcg actgtacaag gcctcgcctg acctggtgcc
661 catgggcgag tggacggcgc gtgtggtaca cctgctcaat gaccagcaca tgggtgtggt
721 cacggccgcc gtcagcctca tcacctgtct ctgcaagaag aacccagatg acttcaagac
781 gtgcgtctct ctggctgtgt cgcgcctgag ccggatcgtc tcctctgcct ccaccgacct
841 ccaggactac acctactact tcgtcccagc accctggctc tcggtgaagc tcctgcggct
901 gctgcagtgc tacccgcttc cagaggatgc ggctgtgaag gggcggctgg tggaatgtct
961 ggagactgtg ctcaacaagg cccaggagcc ccccaaatcc aagaaggtgc agcattccaa
1021 cgccaagaac gccatcctct tcgagaccat cagcctcatc atccactatg acagtgagcc
1081 caacctcctg gttcgggcct gcaaccagct gggccagttc ctgcagcacc gggagaccaa
1141 cctgcgctac ctggccctgg agagcatgtg cacgctggcc agctccgagt tctcccatga
1201 agccgtcaag acgcacattg acaccgtcat caatgccctc aagacggagc gggacgtcag
1261 cgtgcggcag cgggcggctg acctcctcta cgccatgtgt gaccggagca atgccaagca
1321 gatcgtgtcg gagatgctgc ggtacctgga gacggcagac tacgccatcc gcgaggagat
1381 cgtcctgaag gtggccatcc tggccgagaa gtacgccgtg gactacagct ggtacgtgga
1441 caccatcctc aacctcatcc gcattgcggg cgactacgtg agtgaggagg tgtggtaccg
1501 tgtgctacag atcgtcacca accgtgatga cgtccagggc tatgccgcca agaccgtctt
1561 tgaggcgctc caggcccctg cctgtcacga gaacatggtg aaggttggcg gctacatcct
1621 tggggagttt gggaacctga ttgctgggga cccccgctcc agccccccag tgcagttctc
1681 cctgctccac tccaagttcc atctgtgcag cgtggccacg cgggcgctgc tgctgtccac
1741 ctacatcaag ttcatcaacc tcttccccga gaccaaggcc accatccagg gcgtcctgcg
1801 ggccggctcc cagctgcgca atgctgacgt ggagctgcag cagcgagccg tggagtacct
1861 caccctcagc tcagtggcca gcaccgacgt cctggccacg gtgctggagg agatgccgcc
1921 cttccccgag cgcgagtcgt ccatcctggc caagctgaaa cgcaagaagg ggccaggggc
1981 cggcagcgcc ctggacgatg gccggaggga ccccagcagc aacgacatca acgggggcat
2041 ggagcccacc cccagcactg tgtcgacgcc ctcgccctcc gccgacctcc tggggctgcg
2101 ggcagcccct cccccggcag cacccccggc ttctgcagga gcagggaacc ttctggtgga
2161 cgtcttcgat ggcccggccg cccagcccag cctggggccc acccccgagg aggccttcct
2221 cagcccaggt cctgaggaca tcggccctcc cattccggaa gccgatgagt tgctgaataa
2281 gtttgtgtgt aagaacaacg gggtcctgtt cgagaaccag ctgctgcaga tcggagtcaa
2341 gtcagagttc cgacagaacc tgggccgcat gtatctcttc tatggcaaca agacctcggt
2401 gcagttccag aatttctcac ccactgtggt tcacccggga gacctccaga ctcagctggc
2461 tgtgcagacc aagcgcgtgg cggcgcaggt ggacggcggc gcgcaggtgc agcaggtgct
2521 caatatcgag tgcctgcggg acttcctgac gcccccgctg ctgtccgtgc gcttccggta
2581 cggtggcgcc ccccaggccc tcaccctgaa gctcccagtg accatcaaca agttcttcca
2641 gcccaccgag atggcggccc aggatttctt ccagcgctgg aagcagctga gcctccctca
2701 acaggaggcg cagaaaatct tcaaagccaa ccaccccatg gacgcagaag ttactaaggc
2761 caagcttctg gggtttggct ctgctctcct ggacaatgtg gaccccaacc ctggtgacag
2821 agaagacacc agggtttggg ggatgcctgg gactttcctc cggccttttg tatttttatt
2881 tttgttcatc tgctgctgtt tacattctgg ggggttaggg ggagtccccc tccctccctt
2941 tcccccccaa gcacagaggg gagaggggcc agggaagtgg atgtctcctc ccctcccacc
3001 ccaccctgtt gtagcccctc ctaccccctc cccatccagg ggctgtgtat tattgtgagc
3061 gaataaacag agagacgcta aaaaaaaaaa aaaaaaaaaa aaa
//