LOCUS BC013996 1306 bp mRNA linear HUM 03-FEB-2004
DEFINITION Homo sapiens aldo-keto reductase family 7, member A2 (aflatoxin
aldehyde reductase), mRNA (cDNA clone MGC:20271 IMAGE:3625337),
complete cds.
ACCESSION BC013996
VERSION BC013996.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1306)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1306)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (10-SEP-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Dec 19, 2003 this sequence version replaced BC013996.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 28 Row: d Column: 21
This clone was selected for full length sequencing because it
passed the following selection criteria: Similarity but not
identity to protein.
FEATURES Location/Qualifiers
source 1..1306
/db_xref="H-InvDB:HIT000036455"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:20271 IMAGE:3625337"
/tissue_type="Uterus, endometrium adenocarcinoma"
/clone_lib="NIH_MGC_44"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..1306
/gene="AKR7A2"
/gene_synonym="AFAR"
/gene_synonym="AFAR1"
/gene_synonym="AFB1-AR1"
/gene_synonym="AKR7"
/db_xref="GeneID:8574"
/db_xref="MIM:603418"
CDS 41..1033
/gene="AKR7A2"
/gene_synonym="AFAR"
/gene_synonym="AFAR1"
/gene_synonym="AFB1-AR1"
/gene_synonym="AKR7"
/codon_start=1
/product="AKR7A2 protein"
/protein_id="AAH13996.1"
/db_xref="GeneID:8574"
/db_xref="MIM:603418"
/translation="MSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDT
AFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQ
CPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNG
WILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQP
VGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQL
QGAHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFNQAWHLVAHECPNYFR"
misc_feature 77..940
/gene="AKR7A2"
/gene_synonym="AFAR"
/gene_synonym="AFAR1"
/gene_synonym="AFB1-AR1"
/gene_synonym="AKR7"
/note="Aldo_ket_red; Region: Aldo/keto reductase family.
This family includes a number of K+ ion channel beta chain
regulatory domains - these are reported to have
oxidoreductase activity"
/db_xref="CDD:pfam00248"
BASE COUNT 261 a 398 c 384 g 263 t
ORIGIN
1 cgcgcttcgc tctccgccgc ccgaggcccg cgcgctcgcc atgtcccggc caccgccacc
61 gcgggtcgcc tcggtgctgg gcaccatgga gatggggcgc cgcatggacg cgcccgccag
121 cgccgcggcc gtgcgcgcct ttctggagcg cggccacacc gaactggaca cggccttcat
181 gtacagcgac ggccagtccg agaccatcct gggcggcctg gggctcgggc tgggcggtgg
241 cgactgcaga gtgaaaattg ccaccaaggc caacccttgg gatggaaaat cactaaagcc
301 tgacagtgtc cggtcccagc tggagacgtc attgaagagg ctgcagtgtc cccaagtgga
361 cctcttctac ctacacgcac ctgaccacgg caccccggtg gaagagacgc tgcatgcctg
421 ccagcggctg caccaggagg gcaagttcgt ggagcttggc ctctccaact atgctagctg
481 ggaagtggcc gagatctgta ccctctgcaa gagcaatggc tggatcctgc ccactgtgta
541 ccagggcatg tacaacgcca ccacccggca ggtggaaacg gagctcttcc cctgcctcag
601 gcactttgga ctgaggttct atgcctacaa ccctctggct gggggcctgc tgactggcaa
661 gtacaagtat gaggacaagg acgggaaaca gcctgtgggc cgcttctttg ggaatagctg
721 ggctgagacc tacaggaatc gcttctggaa ggagcaccac ttcgaggcca ttgcgttggt
781 ggagaaggcc ctgcaggccg catatggcgc cagcgccccc agtgtgacct cggctgccct
841 ccggtggatg taccaccact cacagctgca gggtgcccac ggggacgcgg tcatcctggg
901 catgtccagc ctggagcagc tggagcagaa cttggcagca acagaggaag ggcccctgga
961 gccggctgtc gtggatgcct ttaatcaagc ctggcatttg gttgctcacg aatgtcccaa
1021 ctacttccgc taggcccatc atggctcagg ctgcccaagg cttttctgtc acctcttttg
1081 ttctctcaca ctgaccagtc ttggccttaa gctgacttag aagggttttt ctgaattgtc
1141 tagatccatg cattattttt ctagcttcct gccttgctcc ctattcactt tacactgtga
1201 aaggtggggg gtgagtccca cttgagcgct tcctgttgaa taaagcaggc acttgacctg
1261 gctgtagcct aggtcttgag tgaaccccaa aaaaaaaaaa aaaaaa
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