LOCUS BC012924 2297 bp mRNA linear HUM 07-OCT-2003
DEFINITION Homo sapiens dual adaptor of phosphotyrosine and
3-phosphoinositides, mRNA (cDNA clone MGC:21117 IMAGE:4517170),
complete cds.
ACCESSION BC012924
VERSION BC012924.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2297)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2297)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (20-AUG-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Baylor College of Medicine Human Genome
Sequencing Center
Center code: BCM-HGSC
Web site: http://www.hgsc.bcm.tmc.edu/cdna/
Contact: amg@bcm.tmc.edu
Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
A.N., Gibbs, R.A.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 28 Row: i Column: 18
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 7657006.
FEATURES Location/Qualifiers
source 1..2297
/db_xref="H-InvDB:HIT000036038"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:21117 IMAGE:4517170"
/tissue_type="Bladder, transitional cell papilloma"
/clone_lib="NIH_MGC_93"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..2297
/gene="DAPP1"
/gene_synonym="BAM32"
/db_xref="GeneID:27071"
/db_xref="MIM:605768"
CDS 16..858
/gene="DAPP1"
/gene_synonym="BAM32"
/codon_start=1
/product="DAPP1 protein"
/protein_id="AAH12924.1"
/db_xref="GeneID:27071"
/db_xref="MIM:605768"
/translation="MGRAELLEGKMSTQDPSDLWSRSDGEAELLQDLGWYHGNLTRHA
AEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTGYSFKFGFNEFSSL
KDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIYESVRVHTAMQTGRTEDDLVPT
APSLGTKEGYLTKQGGLVKTWKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQF
DYSQERVNCFCLVFPFRTFYLCAKTGVEADEWIKILRWKLSQIRKQLNQGEGTIRSRS
FIFK"
misc_feature 118..342
/gene="DAPP1"
/gene_synonym="BAM32"
/note="SH2; Region: SH2 domain"
/db_xref="CDD:pfam00017"
misc_feature 511..780
/gene="DAPP1"
/gene_synonym="BAM32"
/note="PH; Region: Pleckstrin homology domain. Domain
commonly found in eukaryotic signalling proteins. The
domain family possesses multiple functions including the
abilities to bind inositol phosphates, and various
proteins. PH domains have been found to possess inserted
domains (such as in PLC gamma, syntrophins) and to be
inserted within other domains. Mutations in Brutons
tyrosine kinase (Btk) within its PH domain cause X-linked
agammaglobulinaemia (XLA) in patients. Point mutations
cluster into the positively charged end of the molecule
around the predicted binding site for phosphatidylinositol
lipids"
/db_xref="CDD:smart00233"
BASE COUNT 745 a 435 c 466 g 651 t
ORIGIN
1 ctgtgaaggg cgcgaatggg cagagcagaa cttctagaag ggaagatgag cacccaggat
61 ccctcagatc tgtggagcag atccgatgga gaggctgagc tgctccagga cttggggtgg
121 tatcacggca acctcacacg ccatgctgct gaagctcttc tcctctcaaa tggatgtgac
181 ggcagctacc ttctgaggga cagcaatgag accaccgggc tgtactctct ctctgtgagg
241 gccaaagatt ctgttaaaca ctttcatgtt gaatatactg gatattcatt taaatttggc
301 tttaatgaat tctcatcttt gaaggatttt gtcaagcatt ttgcaaatca gcctttgatt
361 ggaagcgaga caggcactct gatggttcta aaacatccct acccaagaaa agtggaagaa
421 ccctccattt atgaatctgt ccgggttcac acagcaatgc agacaggaag aacagaagat
481 gaccttgtgc ccacagcacc ttctctgggc accaaagaag gttacctcac caaacaggga
541 ggcctggtca agacctggaa aacaagatgg tttactctgc acaggaatga actgaaatac
601 ttcaaagacc agatgtcacc agaaccaatt cggatcctag acctaacaga atgttcagct
661 gtacaattcg attattcaca agaaagggta aactgttttt gtttggtatt tccattcagg
721 acattttatc tctgtgcaaa gaccggagta gaagctgatg agtggatcaa gatattacgc
781 tggaaattgt cacaaataag aaaacagctc aaccaagggg aaggcacgat ccgatctcgg
841 tcgttcatct ttaaatagat ctttcttgcc aaggaatgct ctggcccagg agcaaggtgg
901 aatgtttccc tgacgctgtg atctgcagca ggcttcaaat gaaaaccgac taaggatttt
961 ctttcaaaaa caaatcagaa gcagatgctg attgggaccc atataccacg ttgctgactc
1021 acgttgctgc ccttccatga tgttgccatc tccttgagaa cactgaagca atcaccattc
1081 tgatagaaag tgcttaaacc accactctta ggtctgctca ctcttagaac acacaatgga
1141 agaggaaggg tttttgtttt cactcattgt ggtccccaag cctattgaca ctagttgcct
1201 agagtcccac tgtgagtcat ggtcagcctg tctgacatcc aggttgtgct attaaccaag
1261 aaggaaacag atacttggag gcttagatga cttctgcagg atttatattc agatagaaaa
1321 catcaaatat tttcagggga gaggtttttt tttttaattt ttcccccttt atacaaaaaa
1381 aaaagaacat ttccaaaact aaaatagaaa atgcttgtgg catttatttt ctctttttaa
1441 aaggttcaga aatttggcag gtcctttgct tctaatgaca aaactgtgag agctagatgt
1501 cctatgggca attaggtagt ataataaagg taaatgaagg tacaattttt aaaccattat
1561 tttcaccctg ttggggtaaa tgttttaaag agtgagaaaa cataaattga gaaagggtga
1621 taaagtaata gataacttta gtttaataat aattattgtt attatactac taataataga
1681 gcacttgtaa gcactaagtt atctttatcc aacatttctc caaatggact gaaagaaact
1741 tttcaaggac agtgtattat aacaatccct ttcccagaat tagttgtata gggttggccc
1801 aagagatgta agaaaaatct cgcattgctc cctaagcacc ctgggcctta ttaaagagca
1861 acttctattt ccagtcgggg gagtaacact aaagctacaa gaaatatgta ataatgatag
1921 gtaataatgt gttccaaagc tttttcaaac tagaataagg aggcaaatag aagaatgaga
1981 tactgatgtc cacagttcat tggcagaatc taaccccttc tgttatcttt tttaatacta
2041 tttttgttta gatagaagtt tcaaagaaga taaaaatgct tgaagagcct gagagtaaaa
2101 agattatgct gcaaagctat gatataaact gctcttgcag tccaaaggga tacctgatta
2161 aagaagtttc ttatttaaac atctcagacg caaaaattac attaaatttt tgtatatttc
2221 aacaacattt taaatgtatt ttgatgtgtt tgtgtaccat ctgataaagc aaatgtcaag
2281 ttaaaaaaaa aaaaaaa
//