LOCUS BC012181 4033 bp mRNA linear HUM 15-JUL-2006 DEFINITION Homo sapiens furin (paired basic amino acid cleaving enzyme), mRNA (cDNA clone MGC:20463 IMAGE:4550620), complete cds. ACCESSION BC012181 VERSION BC012181.1 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4033) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. CONSRTM Mammalian Gene Collection Program Team TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 4033) CONSRTM NIH MGC Project TITLE Direct Submission JOURNAL Submitted (02-AUG-2001) National Institutes of Health, Mammalian Gene Collection (MGC), Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: DCTD/DTP/Gazdar cDNA Library Preparation: Rubin Laboratory cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: Genome Sequence Centre, BC Cancer Agency, Vancouver, BC, Canada info@bcgsc.bc.ca Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao, Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang, Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAL Plate: 29 Row: b Column: 9 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi: 20336193. FEATURES Location/Qualifiers source 1..4033 /db_xref="H-InvDB:HIT000035718" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:20463 IMAGE:4550620" /tissue_type="Lung, large cell carcinoma" /clone_lib="NIH_MGC_18" /lab_host="DH10B-R" /note="Vector: pOTB7" gene 1..4033 /gene="FURIN" /gene_synonym="SPC1" /db_xref="GeneID:5045" /db_xref="HGNC:HGNC:8568" /db_xref="MIM:136950" CDS 50..2434 /gene="FURIN" /gene_synonym="SPC1" /codon_start=1 /product="furin (paired basic amino acid cleaving enzyme)" /protein_id="AAH12181.1" /db_xref="GeneID:5045" /db_xref="HGNC:HGNC:8568" /db_xref="MIM:136950" /translation="MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAV ANSVARKHGFLNLGQIFGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAK RRTKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNH PDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYN ARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFR GVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACS STLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRD MQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKC IIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSP MGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKF TLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLD THYSTENDVETIRASVCAPCHASCATCQGPALTDCLSCPSHASLDPVEQTCSRQSQSS RESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGLSCAFIVLVFVTVFLVLQLRS GFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEGRGERTAFIKDQSAL" BASE COUNT 783 a 1276 c 1201 g 773 t ORIGIN 1 ccaggccaag gagacgggcg ctccagggtc ccagccacct gtccccccca tggagctgag 61 gccctggttg ctatgggtgg tagcagcaac aggaaccttg gtcctgctag cagctgatgc 121 tcagggccag aaggtcttca ccaacacgtg ggctgtgcgc atccctggag gcccagcggt 181 ggccaacagt gtggcacgga agcatgggtt cctcaacctg ggccagatct tcggggacta 241 ttaccacttc tggcatcgag gagtgacgaa gcggtccctg tcgcctcacc gcccgcggca 301 cagccggctg cagagggagc ctcaagtaca gtggctggaa cagcaggtgg caaagcgacg 361 gactaaacgg gacgtgtacc aggagcccac agaccccaag tttcctcagc agtggtacct 421 gtctggtgtc actcagcggg acctgaatgt gaaggcggcc tgggcgcagg gctacacagg 481 gcacggcatt gtggtctcca ttctggacga tggcatcgag aagaaccacc cggacttggc 541 aggcaattat gatcctgggg ccagttttga tgtcaatgac caggaccctg acccccagcc 601 tcggtacaca cagatgaatg acaacaggca cggcacacgg tgtgcggggg aagtggctgc 661 ggtggccaac aacggtgtct gtggtgtagg tgtggcctac aacgcccgca ttggaggggt 721 gcgcatgctg gatggcgagg tgacagatgc agtggaggca cgctcgctgg gcctgaaccc 781 caaccacatc cacatctaca gtgccagctg gggccccgag gatgacggca agacagtgga 841 tgggccagcc cgcctcgccg aggaggcctt cttccgtggg gttagccagg gccgaggggg 901 gctgggctcc atctttgtct gggcctcggg gaacgggggc cgggaacatg acagctgcaa 961 ctgcgacggc tacaccaaca gtatctacac gctgtccatc agcagcgcca cgcagtttgg 1021 caacgtgccg tggtacagcg aggcctgctc gtccacactg gccacgacct acagcagtgg 1081 caaccagaat gagaagcaga tcgtgacgac tgacttgcgg cagaagtgca cggagtctca 1141 cacgggcacc tcagcctctg cccccttagc agccggcatc attgctctca ccctggaggc 1201 caataagaac ctcacatggc gggacatgca acacctggtg gtacagacct cgaagccagc 1261 ccacctcaat gccaacgact gggccaccaa tggtgtgggc cggaaagtga gccactcata 1321 tggctacggg cttttggacg caggcgccat ggtggccctg gcccagaatt ggaccacagt 1381 ggccccccag cggaagtgca tcatcgacat cctcaccgag cccaaagaca tcgggaaacg 1441 gctcgaggtg cggaagaccg tgaccgcgtg cctgggcgag cccaaccaca tcactcggct 1501 ggagcacgct caggcgcggc tcaccctgtc ctataatcgc cgtggcgacc tggccatcca 1561 cctggtcagc cccatgggca cccgctccac cctgctggca gccaggccac atgactactc 1621 cgcagatggg tttaatgact gggccttcat gacaactcat tcctgggatg aggatccctc 1681 tggcgagtgg gtcctagaga ttgaaaacac cagcgaagcc aacaactatg ggacgctgac 1741 caagttcacc ctcgtactct atggcaccgc ccctgagggg ctgcccgtac ctccagaaag 1801 cagtggctgc aagaccctca cgtccagtca ggcctgtgtg gtgtgcgagg aaggcttctc 1861 cctgcaccag aagagctgtg tccagcactg ccctccaggc ttcgcccccc aagtcctcga 1921 tacgcactat agcaccgaga atgacgtgga gaccatccgg gccagcgtct gcgccccctg 1981 ccacgcctca tgtgccacat gccaggggcc ggccctgaca gactgcctca gctgccccag 2041 ccacgcctcc ttggaccctg tggagcagac ttgctcccgg caaagccaga gcagccgaga 2101 gtccccgcca cagcagcagc cacctcggct gcccccggag gtggaggcgg ggcaacggct 2161 gcgggcaggg ctgctgccct cacacctgcc tgaggtggtg gccggcctca gctgcgcctt 2221 catcgtgctg gtcttcgtca ctgtcttcct ggtcctgcag ctgcgctctg gctttagttt 2281 tcggggggtg aaggtgtaca ccatggaccg tggcctcatc tcctacaagg ggctgccccc 2341 tgaagcctgg caggaggagt gcccgtctga ctcagaagag gacgagggcc ggggcgagag 2401 gaccgccttt atcaaagacc agagcgccct ctgatgagcc cactgcccac cccctcaagc 2461 caatcccctc cttgggcact ttttaattca ccaaagtatt tttttatctt gggactgggt 2521 ttggacccca gctgggaggc aagaggggtg gagactgctt cccatcctac cctcgggccc 2581 acctggccac ctgaggtggg cccaggacca gctggggcgt ggggagggcc gtaccccacc 2641 ctcagcaccc cttccatgtg gagaaaggag tgaaaccttt agggcagctt gccccggccc 2701 cggccccagc cagagttcct gcggagtgaa gaggggcagc ccttgcttgt tgggattcct 2761 gacccaggcc gcagctcttg cccttccctg tccctctaaa gcaataatgg tcccatccag 2821 gcagtcgggg gctggcctag gagatatctg agggaggagg ccacctctcc aagggcttct 2881 gcaccctcca ccctgtcccc cagctctggt gagtcttggc ggcagcagcc atcataggaa 2941 gggaccaagg caaggcaggt gcctccaggt gtgcacgtgg catgtggcct gtggcctgtg 3001 tcccatgacc cacccctgtg ctccgtgcct ccaccaccac tggccaccag gctggcgcag 3061 ccaaggccga agctctggct gaaccctgtg ctggtgtcct gaccaccctc ccctctcttg 3121 cacccgcctc tcccgtcagg gcccaagtcc ctgttttctg agcccgggct gcctgggctg 3181 ttggcactca cagacctgga gcccctgggt gggtggtggg gaggggcgct ggcccagccg 3241 gcctctctgg cctcccaccc gatgctgctt tcccctgtgg ggatctcagg ggctgtttga 3301 ggatatattt tcactttgtg attatttcac tttagatgct gatgatttgt ttttgtattt 3361 ttaatggggg tagcagctgg actacccacg ttctcacacc caccgtccgc cctgctcctc 3421 cctggctgcc ctggccctga ggtgtggggg ctgcagcatg ttgctgagga gtgaggaata 3481 gttgagcccc aagtcctgaa gaggcgggcc agccaggcgg gctcaaggaa agggggtccc 3541 agtgggaggg gcaggctgac atctgtgttt caagtggggc tcgccatgcc gggggttcat 3601 aggtcactgg ctctccaagt gccagaggtg ggcaggtggt ggcactgagc ccccccaaca 3661 ctgtgccctg gtggagaaag cactgacctg tcatgccccc ctcaaacctc ctcttctgac 3721 gtgccttttg cacccctccc attaggacaa tcagtcccct cccatctggg agtccccttt 3781 tcttttctac cctagccatt cctggtaccc agccatctgc ccaggggtgc cccctcctct 3841 cccatccccc tgccctcgtg gccagcccgg ctggttttgt aagatgctgg gttggtgcac 3901 agtgattttt ttcttgtaat ttaaacaggc ccagcattgc tggttctatt taatggacat 3961 gagataatgt tagaggtttt aaagtgatta aacgtgcaga ctatgcaaac cagaaaaaaa 4021 aaaaaaaaaa aaa //