LOCUS BC012181 4033 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens furin (paired basic amino acid cleaving enzyme), mRNA
(cDNA clone MGC:20463 IMAGE:4550620), complete cds.
ACCESSION BC012181
VERSION BC012181.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4033)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4033)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (02-AUG-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: DCTD/DTP/Gazdar
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 29 Row: b Column: 9
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 20336193.
FEATURES Location/Qualifiers
source 1..4033
/db_xref="H-InvDB:HIT000035718"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:20463 IMAGE:4550620"
/tissue_type="Lung, large cell carcinoma"
/clone_lib="NIH_MGC_18"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..4033
/gene="FURIN"
/gene_synonym="SPC1"
/db_xref="GeneID:5045"
/db_xref="HGNC:HGNC:8568"
/db_xref="MIM:136950"
CDS 50..2434
/gene="FURIN"
/gene_synonym="SPC1"
/codon_start=1
/product="furin (paired basic amino acid cleaving enzyme)"
/protein_id="AAH12181.1"
/db_xref="GeneID:5045"
/db_xref="HGNC:HGNC:8568"
/db_xref="MIM:136950"
/translation="MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAV
ANSVARKHGFLNLGQIFGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAK
RRTKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNH
PDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYN
ARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFR
GVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACS
STLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRD
MQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKC
IIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSP
MGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKF
TLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLD
THYSTENDVETIRASVCAPCHASCATCQGPALTDCLSCPSHASLDPVEQTCSRQSQSS
RESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGLSCAFIVLVFVTVFLVLQLRS
GFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEGRGERTAFIKDQSAL"
BASE COUNT 783 a 1276 c 1201 g 773 t
ORIGIN
1 ccaggccaag gagacgggcg ctccagggtc ccagccacct gtccccccca tggagctgag
61 gccctggttg ctatgggtgg tagcagcaac aggaaccttg gtcctgctag cagctgatgc
121 tcagggccag aaggtcttca ccaacacgtg ggctgtgcgc atccctggag gcccagcggt
181 ggccaacagt gtggcacgga agcatgggtt cctcaacctg ggccagatct tcggggacta
241 ttaccacttc tggcatcgag gagtgacgaa gcggtccctg tcgcctcacc gcccgcggca
301 cagccggctg cagagggagc ctcaagtaca gtggctggaa cagcaggtgg caaagcgacg
361 gactaaacgg gacgtgtacc aggagcccac agaccccaag tttcctcagc agtggtacct
421 gtctggtgtc actcagcggg acctgaatgt gaaggcggcc tgggcgcagg gctacacagg
481 gcacggcatt gtggtctcca ttctggacga tggcatcgag aagaaccacc cggacttggc
541 aggcaattat gatcctgggg ccagttttga tgtcaatgac caggaccctg acccccagcc
601 tcggtacaca cagatgaatg acaacaggca cggcacacgg tgtgcggggg aagtggctgc
661 ggtggccaac aacggtgtct gtggtgtagg tgtggcctac aacgcccgca ttggaggggt
721 gcgcatgctg gatggcgagg tgacagatgc agtggaggca cgctcgctgg gcctgaaccc
781 caaccacatc cacatctaca gtgccagctg gggccccgag gatgacggca agacagtgga
841 tgggccagcc cgcctcgccg aggaggcctt cttccgtggg gttagccagg gccgaggggg
901 gctgggctcc atctttgtct gggcctcggg gaacgggggc cgggaacatg acagctgcaa
961 ctgcgacggc tacaccaaca gtatctacac gctgtccatc agcagcgcca cgcagtttgg
1021 caacgtgccg tggtacagcg aggcctgctc gtccacactg gccacgacct acagcagtgg
1081 caaccagaat gagaagcaga tcgtgacgac tgacttgcgg cagaagtgca cggagtctca
1141 cacgggcacc tcagcctctg cccccttagc agccggcatc attgctctca ccctggaggc
1201 caataagaac ctcacatggc gggacatgca acacctggtg gtacagacct cgaagccagc
1261 ccacctcaat gccaacgact gggccaccaa tggtgtgggc cggaaagtga gccactcata
1321 tggctacggg cttttggacg caggcgccat ggtggccctg gcccagaatt ggaccacagt
1381 ggccccccag cggaagtgca tcatcgacat cctcaccgag cccaaagaca tcgggaaacg
1441 gctcgaggtg cggaagaccg tgaccgcgtg cctgggcgag cccaaccaca tcactcggct
1501 ggagcacgct caggcgcggc tcaccctgtc ctataatcgc cgtggcgacc tggccatcca
1561 cctggtcagc cccatgggca cccgctccac cctgctggca gccaggccac atgactactc
1621 cgcagatggg tttaatgact gggccttcat gacaactcat tcctgggatg aggatccctc
1681 tggcgagtgg gtcctagaga ttgaaaacac cagcgaagcc aacaactatg ggacgctgac
1741 caagttcacc ctcgtactct atggcaccgc ccctgagggg ctgcccgtac ctccagaaag
1801 cagtggctgc aagaccctca cgtccagtca ggcctgtgtg gtgtgcgagg aaggcttctc
1861 cctgcaccag aagagctgtg tccagcactg ccctccaggc ttcgcccccc aagtcctcga
1921 tacgcactat agcaccgaga atgacgtgga gaccatccgg gccagcgtct gcgccccctg
1981 ccacgcctca tgtgccacat gccaggggcc ggccctgaca gactgcctca gctgccccag
2041 ccacgcctcc ttggaccctg tggagcagac ttgctcccgg caaagccaga gcagccgaga
2101 gtccccgcca cagcagcagc cacctcggct gcccccggag gtggaggcgg ggcaacggct
2161 gcgggcaggg ctgctgccct cacacctgcc tgaggtggtg gccggcctca gctgcgcctt
2221 catcgtgctg gtcttcgtca ctgtcttcct ggtcctgcag ctgcgctctg gctttagttt
2281 tcggggggtg aaggtgtaca ccatggaccg tggcctcatc tcctacaagg ggctgccccc
2341 tgaagcctgg caggaggagt gcccgtctga ctcagaagag gacgagggcc ggggcgagag
2401 gaccgccttt atcaaagacc agagcgccct ctgatgagcc cactgcccac cccctcaagc
2461 caatcccctc cttgggcact ttttaattca ccaaagtatt tttttatctt gggactgggt
2521 ttggacccca gctgggaggc aagaggggtg gagactgctt cccatcctac cctcgggccc
2581 acctggccac ctgaggtggg cccaggacca gctggggcgt ggggagggcc gtaccccacc
2641 ctcagcaccc cttccatgtg gagaaaggag tgaaaccttt agggcagctt gccccggccc
2701 cggccccagc cagagttcct gcggagtgaa gaggggcagc ccttgcttgt tgggattcct
2761 gacccaggcc gcagctcttg cccttccctg tccctctaaa gcaataatgg tcccatccag
2821 gcagtcgggg gctggcctag gagatatctg agggaggagg ccacctctcc aagggcttct
2881 gcaccctcca ccctgtcccc cagctctggt gagtcttggc ggcagcagcc atcataggaa
2941 gggaccaagg caaggcaggt gcctccaggt gtgcacgtgg catgtggcct gtggcctgtg
3001 tcccatgacc cacccctgtg ctccgtgcct ccaccaccac tggccaccag gctggcgcag
3061 ccaaggccga agctctggct gaaccctgtg ctggtgtcct gaccaccctc ccctctcttg
3121 cacccgcctc tcccgtcagg gcccaagtcc ctgttttctg agcccgggct gcctgggctg
3181 ttggcactca cagacctgga gcccctgggt gggtggtggg gaggggcgct ggcccagccg
3241 gcctctctgg cctcccaccc gatgctgctt tcccctgtgg ggatctcagg ggctgtttga
3301 ggatatattt tcactttgtg attatttcac tttagatgct gatgatttgt ttttgtattt
3361 ttaatggggg tagcagctgg actacccacg ttctcacacc caccgtccgc cctgctcctc
3421 cctggctgcc ctggccctga ggtgtggggg ctgcagcatg ttgctgagga gtgaggaata
3481 gttgagcccc aagtcctgaa gaggcgggcc agccaggcgg gctcaaggaa agggggtccc
3541 agtgggaggg gcaggctgac atctgtgttt caagtggggc tcgccatgcc gggggttcat
3601 aggtcactgg ctctccaagt gccagaggtg ggcaggtggt ggcactgagc ccccccaaca
3661 ctgtgccctg gtggagaaag cactgacctg tcatgccccc ctcaaacctc ctcttctgac
3721 gtgccttttg cacccctccc attaggacaa tcagtcccct cccatctggg agtccccttt
3781 tcttttctac cctagccatt cctggtaccc agccatctgc ccaggggtgc cccctcctct
3841 cccatccccc tgccctcgtg gccagcccgg ctggttttgt aagatgctgg gttggtgcac
3901 agtgattttt ttcttgtaat ttaaacaggc ccagcattgc tggttctatt taatggacat
3961 gagataatgt tagaggtttt aaagtgatta aacgtgcaga ctatgcaaac cagaaaaaaa
4021 aaaaaaaaaa aaa
//