LOCUS BC011669 4254 bp mRNA linear HUM 14-SEP-2006
DEFINITION Homo sapiens 24-dehydrocholesterol reductase, mRNA (cDNA clone
MGC:15380 IMAGE:4130396), complete cds.
ACCESSION BC011669
VERSION BC011669.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4254)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4254)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (30-JUL-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Aug 19, 2003 this sequence version replaced BC011669.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 26 Row: j Column: 2
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 56790943.
FEATURES Location/Qualifiers
source 1..4254
/db_xref="H-InvDB:HIT000035358"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:15380 IMAGE:4130396"
/tissue_type="Brain, neuroblastoma"
/clone_lib="NIH_MGC_19"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..4254
/gene="DHCR24"
/gene_synonym="KIAA0018"
/gene_synonym="Nbla03646"
/gene_synonym="seladin-1"
/gene_synonym="SELADIN1"
/db_xref="GeneID:1718"
/db_xref="HGNC:HGNC:2859"
/db_xref="MIM:606418"
CDS 63..1613
/gene="DHCR24"
/gene_synonym="KIAA0018"
/gene_synonym="Nbla03646"
/gene_synonym="seladin-1"
/gene_synonym="SELADIN1"
/codon_start=1
/product="24-dehydrocholesterol reductase"
/protein_id="AAH11669.1"
/db_xref="GeneID:1718"
/db_xref="HGNC:HGNC:2859"
/db_xref="MIM:606418"
/translation="MEPAVSLAVCALLFLLWVRLKGLEFVLIHQRWVFVCLFLLPLSL
IFDIYYYVRAWVVFKLSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSL
RVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELD
DLTVGGLIMGTGIESSSHKYGLFQHICTAYELVLADGSFVRCTPSENSDLFYAVPWSC
GTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDE
AVIMTGVMTDEAEPSKLNSIGNYYKPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRS
IFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMK
CLQQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGNEAELYIDIGAYGEPRVKHFEA
RSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYHKLREKLGCQDAFPEVYD
KICKAARH"
BASE COUNT 957 a 1157 c 1148 g 992 t
ORIGIN
1 gcggagctgg cggcagtgac aggaggcgcg aacccgcagc gcttaccgcg cggcgccgca
61 ccatggagcc cgccgtgtcg ctggccgtgt gcgcgctgct cttcctgctg tgggtgcgcc
121 tgaaggggct ggagttcgtg ctcatccacc agcgctgggt gttcgtgtgc ctcttcctcc
181 tgccgctctc gcttatcttc gatatctact actacgtgcg cgcctgggtg gtgttcaagc
241 tcagcagcgc tccgcgcctg cacgagcagc gcgtgcggga catccagaag caggtgcggg
301 aatggaagga gcagggtagc aagaccttca tgtgcacggg gcgccctggc tggctcactg
361 tctcactacg tgtcgggaag tacaagaaga cacacaaaaa catcatgatc aacctgatgg
421 acattctgga agtggacacc aagaaacaga ttgtccgtgt ggagcccttg gtgaccatgg
481 gccaggtgac tgccctgctg acctccattg gctggactct ccccgtgttg cctgagcttg
541 atgacctcac agtggggggc ttgatcatgg gcacaggcat cgagtcatca tcccacaagt
601 acggcctgtt ccaacacatc tgcactgctt acgagctggt cctggctgat ggcagctttg
661 tgcgatgcac tccgtccgaa aactcagacc tgttctatgc cgtaccctgg tcctgtggga
721 cgctgggttt cctggtggcc gctgagatcc gcatcatccc tgccaagaag tacgtcaagc
781 tgcgtttcga gccagtgcgg ggcctggagg ctatctgtgc caagttcacc cacgagtccc
841 agcggcagga gaaccacttc gtggaagggc tgctctactc cctggatgag gctgtcatta
901 tgacaggggt catgacagat gaggcagagc ccagcaagct gaatagcatt ggcaattact
961 acaagccgtg gttctttaag catgtggaga actatctgaa gacaaaccga gagggcctgg
1021 agtacattcc cttgagacac tactaccacc gccacacgcg cagcatcttc tgggagctcc
1081 aggacatcat cccctttggc aacaacccca tcttccgcta cctctttggc tggatggtgc
1141 ctcccaagat ctccctcctg aagctgaccc agggtgagac cctgcgcaag ctgtacgagc
1201 agcaccacgt ggtgcaggac atgctggtgc ccatgaagtg cctgcagcag gccctgcaca
1261 ccttccaaaa cgacatccac gtctacccca tctggctgtg tccgttcatc ctgcccagcc
1321 agccaggcct agtgcacccc aaaggaaatg aggcagagct ctacatcgac attggagcat
1381 atggggagcc gcgtgtgaaa cactttgaag ccaggtcctg catgaggcag ctggagaagt
1441 ttgtccgcag cgtgcatggc ttccagatgc tgtatgccga ctgctacatg aaccgggagg
1501 agttctggga gatgtttgat ggctccttgt accacaagct gcgagagaag ctgggttgcc
1561 aggacgcctt ccccgaggtg tacgacaaga tctgcaaggc cgccaggcac tgagctggag
1621 cccgcctgga gagacagaca cgtgtgagtg gtcaggcatc ttcccttcac tcaagcttgg
1681 ctgctttcct agatccacac tttcaaagag aaacccctcc agaactccca ccctgacagc
1741 ccaacaccac cttcctcctg gcttccaggg ggcagcccag tggaatggaa agaatgtggg
1801 atttggagtc agacaagcct gagtccagtt ccccgtttag aactcattag ctgtgtgact
1861 ctgggtgagt cccttaaccc ctctgagccc gggtctcttc attagttgaa agggatagta
1921 atacctactt gcaggttgtt gtcatctgag ttgagcactg gtcacattga aggtgctggg
1981 taagtggtag ctcttgttgc ttcccgttca gcgtcacatc tgcagtggag cctgaaaagg
2041 ctccacatta ggtcacctgt gcacagccat ggctggaatg atgaagggga tacgctggag
2101 ttgccctgcc atcgcctcca tcagccagac gaggtcctca caggagaagg acagctcttc
2161 cccaccctgg gatctcagga gggcagccac ggagtgggga ggccccagat gcgctgtgcc
2221 aaagccaggt ccgaggccaa agttctccct gccatccttg gtgccgtcct gccccttcct
2281 ccttcatgcc tgggcctgca ggcccacccc agccaccact gagtccactc ggagtgccct
2341 gtgttcctgg agaaggcatt ccagggttga atcttgtccc agcctcagcc tgggacacct
2401 aggtggagag agtggtctcc gctctgaatt ggatccaggg gacctgggct cattcttctt
2461 ggctcaccaa ccctgcaggc ctcatctttc ccaaaaccca ctttgtcttg gtgggagtgg
2521 gtccgcgctg ctctgcagca ggggctgggg agtgggcagc atcaggtggg aaagtggagt
2581 ccaccctcat gtttctgtag gattctcacc gtggggctgg aagaaaagag catcgacttg
2641 atttctccaa ccactcatcc ctctttttct ttcttccacc actccccacc ccagctgtag
2701 ttaatttcag tgccttacaa atcctaagct cagagaaagt tccatttccg ttccagaggg
2761 aagggaacct ccctaggtcc ttccctggct tgttataacg caaagcttgg ttgtttatgc
2821 aactctatct taagaactgc ccagcctcag ctgaaaaccc gaatctgaga aggaattgcg
2881 tcatgtaagg gaagctggaa ttaagggagc tgagccagtc atggttgtgg cgtgtgagtc
2941 aggagaccta ggtttcagcc cctctctact gtcagcgagc tgtgcaacgt gggcaagtca
3001 ttgtcctctg agctgcagtt tcctcatctg tcacatcgct acagacaaga cctccctgga
3061 acccttctga ttgtcttaga cactgtggtt gcaaaaccca cggaaagcct catttgtgtg
3121 gaaagtcaga ggaaaaatga tccagtggac acttggggat tatctgtcat tcaagatcct
3181 tccttcaacc ccaaggtcag ctcccatctc atttccagaa aggctcatac ctggcttgca
3241 gggaagcatc tgtcttgtca ttccaggtgc cagaatcctc tcagagtcat tgaagggtgt
3301 tcacccatcc cacccaaggc ttggcacact gccagtgtct tagcagggtc ttgtgagggc
3361 tgggggcatc caggcactca gaaggcaaag gaaccaccct acccatttgg cctctggagg
3421 gggcagaaga aagaaagaaa cctcatccta tattttacaa agcatgtgaa ttctggcatt
3481 agctctcata ggagacccat gtgcttcctt gctcagtgca aaactgatga ttctacttgc
3541 tgtagatgaa tggttaacac gagctagtta aacagtgcca ttgttttgcc agtgaagcct
3601 ccaaccctaa gccactggga cggtggccag agatgccagc agcctctgtc gcccttagtc
3661 atataaccaa aatccagacc ttatccacaa cccggggctt ggaaaggaag gtattttgga
3721 atcacaccct ccggttatgt tgctccagta aaatcttgcc tggaaagagg cagtcttctt
3781 agcatggtga gctgagttca tggctttttt ttgtagccag tcctgtccct ggccatccat
3841 gtgatggttt tggatggagt taaacttgat gccagtgggc agtgcatgtg gaaagtatca
3901 gagtaaggct ctcccctcca gagccctgag tttcttggct gcatgaaggt tttctttaga
3961 atcagaattg tagccagttt ctttggccag aaggatgaat acttggatat tactgaaagg
4021 gaggggtgga gatgggtgtg gcagtgtatg gtgtgtgatt tttattttct tctttggtca
4081 tgggggccaa ggagaaaggc atgaatcttc cctgtcaggc tcttacagcc acaggcactg
4141 tgtctactgt ctggaagaca tgtccccgtg gctgtggggc cgctgcttct gtttaaataa
4201 aagtggcctg gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//