LOCUS BC011377 2272 bp mRNA linear HUM 27-JAN-2004
DEFINITION Homo sapiens leucine rich repeat containing 14, mRNA (cDNA clone
MGC:9269 IMAGE:3853673), complete cds.
ACCESSION BC011377
VERSION BC011377.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2272)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2272)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (25-JUL-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Baylor College of Medicine Human Genome
Sequencing Center
Center code: BCM-HGSC
Web site: http://www.hgsc.bcm.tmc.edu/cdna/
Contact: amg@bcm.tmc.edu
Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
A.N., Gibbs, R.A.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 13 Row: a Column: 17
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 7661859.
FEATURES Location/Qualifiers
source 1..2272
/db_xref="H-InvDB:HIT000035229"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:9269 IMAGE:3853673"
/tissue_type="Colon, adenocarcinoma"
/clone_lib="NIH_MGC_65"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..2272
/gene="LRRC14"
/gene_synonym="KIAA0014"
/db_xref="GeneID:9684"
CDS 216..1697
/gene="LRRC14"
/gene_synonym="KIAA0014"
/codon_start=1
/product="LRRC14 protein"
/protein_id="AAH11377.1"
/db_xref="GeneID:9684"
/translation="MHTLVFLSTRQVLQCQPAACQALPLLPRELFPLLFKVAFMDKKT
VVLRELVHTWPFPLLSFQQLLQECAHCSRALLQERPSTESMQAVILGLTARLHTSEPG
ASTQPLCRKHALRVLDMTGLLDDGVEQDPGTMSMWDCTAAVARTCIAQQQGGAAEPGP
APIPVEVRVDLRVNRASYAFLREALRSSVGSPLRLCCRDLRAEDLPMRNTVALLQLLD
AGCLRRVDLRFNNLGLRGLSVIIPHVARFQHLASLRLHYVHGDSRQPSVDGEDNFRYF
LAQMGRFTCLRELSMGSSLLSGRLDQLLSTLQSPLESLELAFCALLPEDLRFLARSPH
AAHLKKLDLSGNDLSGSQLAPFQGLLQASAATLLHLELTECQLADTQLLATLPILTQC
ASLRYLGLYGNPLSMAGLKELLRDSVAQAELRTVVHPFPVDCYEGLPWPPPASVLLEA
SINEEKFARVEAELHQLLLASGRAHVLWTTDIYGRLAADYFSL"
misc_feature 1125..1457
/gene="LRRC14"
/gene_synonym="KIAA0014"
/note="LRR_RI; Region: Leucine-rich repeats (LRRs),
ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29
residue sequence motifs present in many proteins that
participate in protein-protein interactions and have
different functions and cellular locations. LRRs
correspond to structural units consisting of a beta strand
(LxxLxLxxN/CxL conserved pattern) and an alpha helix. This
alignment contains 12 strands corresponding to 11 full
repeats, consistent with the extent observed in the
subfamily acting as Ran GTPase Activating Proteins
(RanGAP1)"
/db_xref="CDD:cd00116"
BASE COUNT 377 a 713 c 688 g 494 t
ORIGIN
1 ggcggggctg gaggcggtgg ctgcggttgc gggaccggga gatggctgcg atttagtttt
61 gaggatgcta caggcagcag cagggctggc accctgtgtc acaggcacta tgctgggcct
121 tcctaccact tgtgtgtggc ttggtagtgg cctagggtct ctcctccctg ctgaagtccc
181 tctcctgcag gtggccgtct gcccggccca gcaccatgca cacgcttgtg ttcttgagca
241 cacggcaggt gctgcagtgc cagccagctg cctgccaggc cctgcccctg ctgccacgcg
301 aactcttccc cctgctgttc aaggtggcct tcatggacaa gaagacagtg gtactgcgcg
361 agttggtaca cacgtggccc ttcccgctgc tcagtttcca gcagctgcta caggagtgtg
421 cccactgcag ccgtgccctc ctgcaggagc ggcctagcac tgagagcatg caggctgtta
481 tcctggggct gactgcccgg ctccacacct cagagcctgg ggccagcaca cagcccctct
541 gcaggaagca tgcgctgcgg gtgctggaca tgacgggcct cttggatgat ggtgtggaac
601 aggatcctgg caccatgagc atgtgggact gtactgctgc cgtagctcgc acatgcattg
661 cccagcagca gggtggggcc gcagagcctg ggccagcccc catccccgtg gaggtgcgcg
721 tggacctgcg ggtgaaccgg gcctcctatg cgttcctgcg ggaggcactc cgaagcagcg
781 tgggcagccc gctgcggctc tgctgccggg acctgcgagc tgaggacctg cccatgcgca
841 acactgtggc cctgctgcag cttctggatg caggctgcct gcgccgcgtg gacctgcgct
901 tcaacaatct gggcctgcgc ggcctgtctg tgatcatccc acacgtggcc cgcttccagc
961 acctggccag cctgcggctc cactatgtgc atggggattc aaggcagccc tccgtggatg
1021 gcgaggacaa cttccgctac ttccttgccc agatgggccg cttcacctgt ctgcgtgagc
1081 tcagcatggg ctcctctctc ctttcaggga ggctggacca gctgctcagc accctgcaga
1141 gccccctgga gagcctggag ttggccttct gtgctctgct gcctgaggac ctacgcttcc
1201 tggcacggag cccacatgct gcccacctca agaagttgga cctgagtggt aacgacctgt
1261 ctggcagcca gctggcaccc ttccagggtc tgttgcaggc atcagcagcc acactgttgc
1321 atctggagct gactgagtgt cagctcgcag acacccagct gttggccaca ctacccatcc
1381 tgactcagtg cgccagtctc cggtaccttg gcctctatgg caacccactg tccatggcgg
1441 gcctcaagga gctgctgcgg gactcagtgg cacaggctga gctgcgtact gtggtgcacc
1501 ccttccctgt ggactgctat gagggcttgc cctggccgcc gcctgcctct gtcctgctgg
1561 aggcctccat caatgaggag aagtttgccc gcgtagaagc tgagttgcac cagctgcttc
1621 tagcctcagg ccgtgcccat gtgctctgga ccacggacat ctacgggcga ctggctgcgg
1681 actacttcag cctatgatga agtagctctg ggtgagacac aggccgccct gcagtctctt
1741 taggtaggca gggcctttgc tgggacccct ggtggaggcc ttcacaaaag cactggttac
1801 tggtttcctg ctgggtctac cttgcttctg ggcacacctc aagcctcccc tgctttctgc
1861 agtgccccac gcggttttcc ctgcacttgc tccataattg gctgatcatc tgtgggcccc
1921 ggggctggat gtcaggcctc cattgccctg ctcagtttgg ctgcatttgg ctgccgtctg
1981 gggtcctggt cctttgtgca aatgctttgg gattccagtt gtgagctgag agagatgatg
2041 gcctctctgg gcctttcctc tccctttact gagagctcag tgcttttggg gttgaagttg
2101 gacagaggcc tgcttcaggg aagctgggag tccccaggca ctcacgcctt ttacgtgttc
2161 cctaccctgc cacccagcca ccccactggg ctgggctcgg gctggagggg gtcatcaagg
2221 tacacatgtg cctggaagtt gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//