LOCUS BC011368 2757 bp mRNA linear HUM 19-JUN-2008
DEFINITION Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 4, mRNA (cDNA
clone MGC:9873 IMAGE:3867403), complete cds.
ACCESSION BC011368
VERSION BC011368.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2757)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2757)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (25-JUL-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Baylor College of Medicine Human Genome
Sequencing Center
Center code: BCM-HGSC
Web site: http://www.hgsc.bcm.tmc.edu/cdna/
Contact: amg@bcm.tmc.edu
Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
A.N., Gibbs, R.A.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 13 Row: g Column: 5
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 62422555.
FEATURES Location/Qualifiers
source 1..2757
/db_xref="H-InvDB:HIT000035223"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:9873 IMAGE:3867403"
/tissue_type="Eye, retinoblastoma"
/clone_lib="NIH_MGC_67"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..2757
/gene="PAK4"
/db_xref="GeneID:10298"
/db_xref="HGNC:HGNC:16059"
/db_xref="MIM:605451"
CDS 141..1916
/gene="PAK4"
/codon_start=1
/product="p21 protein (Cdc42/Rac)-activated kinase 4"
/protein_id="AAH11368.1"
/db_xref="GeneID:10298"
/db_xref="HGNC:HGNC:16059"
/db_xref="MIM:605451"
/translation="MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIE
ESARRPKPLVDPACITSIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRR
DSPPPPARARQENGMPEEPATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRP
KSSREGSGGPQESSRDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSR
GAQGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPAC
TPAAPAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGI
VCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELW
VVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTH
DGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEM
VDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAEL
LKHPFLAKAGPPASIVPLMRQNRTR"
BASE COUNT 525 a 934 c 851 g 447 t
ORIGIN
1 ttcaacatgg cggcgggagt gtccgcggtg gtggcggtgc aagagagctg aaggaggcgc
61 gagggcgcgg agttccaggc cgagcagtta ggccgcgagc gactgcggcg ccgagccggc
121 cgcaccgagt ccccggcacc atgtttggga agaggaagaa gcgggtggag atctccgcgc
181 cgtccaactt cgagcaccgc gtgcacacgg gcttcgacca gcacgagcag aagttcacgg
241 ggctgccccg ccagtggcag agcctgatcg aggagtcggc tcgccggccc aagcccctcg
301 tcgaccccgc ctgcatcacc tccatccagc ccggggcccc caagaccatc gtgcggggca
361 gcaaaggtgc caaagatggg gccctcacgc tgctgctgga cgagtttgag aacatgtcgg
421 tgacacgctc caactccctg cggagagaca gcccgccgcc gcccgcccgt gcccgccagg
481 aaaatgggat gccagaggag ccggccacca cggccagagg gggcccaggg aaggcaggca
541 gccgaggccg gttcgccggt cacagcgagg cgggtggcgg cagtggtgac aggcgacggg
601 cggggccaga gaagaggccc aagtcttcca gggagggctc agggggtccc caggagtcct
661 cccgggacaa acgccccctc tccgggcctg atgtcggcac cccccagcct gctggtctgg
721 ccagtggggc gaaactggca gctggccggc cctttaacac ctacccgagg gctgacacgg
781 accacccatc ccggggtgcc cagggggagc ctcatgacgt ggcccctaac gggccatcag
841 cggggggcct ggccatcccc cagtcctcct cctcctcctc ccggcctccc acccgagccc
901 gaggtgcccc cagccctgga gtgctgggac cccacgcctc agagccccag ctggcccctc
961 cagcctgcac ccccgccgcc cctgctgttc ctgggccccc tggcccccgc tcaccacagc
1021 gggagccaca gcgagtatcc catgagcagt tccgggctgc cctgcagctg gtggtggacc
1081 caggcgaccc ccgctcctac ctggacaact tcatcaagat tggcgagggc tccacgggca
1141 tcgtgtgcat cgccaccgtg cgcagctcgg gcaagctggt ggccgtcaag aagatggacc
1201 tgcgcaagca gcagaggcgc gagctgctct tcaacgaggt ggtaatcatg agggactacc
1261 agcacgagaa tgtggtggag atgtacaaca gctacctggt gggggacgag ctctgggtgg
1321 tcatggagtt cctggaagga ggcgccctca ccgacatcgt cacccacacc aggatgaacg
1381 aggagcagat cgcggccgtg tgccttgcag tgctgcaggc cctgtcggtg ctccacgccc
1441 agggcgtcat ccaccgggac atcaagagcg actcgatcct gctgacccat gatggcaggg
1501 tgaagctgtc agactttggg ttctgcgccc aggtgagcaa ggaagtgccc cgaaggaagt
1561 cgctggtcgg cacgccctac tggatggccc cagagctcat ctcccgcctt ccctacgggc
1621 cagaggtaga catctggtcg ctggggataa tggtgattga gatggtggac ggagagcccc
1681 cctacttcaa cgagccaccc ctcaaagcca tgaagatgat tcgggacaac ctgccacccc
1741 gactgaagaa cctgcacaag gtgtcgccat ccctgaaggg cttcctggac cgcctgctgg
1801 tgcgagaccc tgcccagcgg gccacggcag ccgagctgct gaagcaccca ttcctggcca
1861 aggcagggcc gcctgccagc atcgtgcccc tcatgcgcca gaaccgcacc agatgaggcc
1921 cagcgccctt cccctcaacc aaagagcccc ccgggtcacc cccgccccac tgaggccagt
1981 agggggccag gcctcccact cctcccagcc cgggagatgc tccgcgtggc accaccctcc
2041 ttgctggggg tagatgagac cctactactg aactccagtt ttgatctcgt gacttttaga
2101 aaaacacagg gactcgtggg agcaagcgag gctcccagga cccccaccct ctgggacagg
2161 ccctccccca tgttcttctg tctccaggaa gggcagcagc cctcccatca ctggaagtct
2221 gcagtggggg tcgctggggg tggagagaac actaagaggt gaacatgtat gagtgtgtgc
2281 acgcgtgtga gtgtgcatgt gtgtgtgtgt gcaaaggtcc agccaccccg tcctccagcc
2341 tgcaaggggt gtctggcgcc ttgcctgaca cccagccccc tctccccctg agccattgtg
2401 ggggtcgatc atgaatgtcc gaagagtggc cttttcccgt agccctgcgc cccctttctg
2461 tggctggatg gggagacagg tcagggcccc ccaccctctc cagcccctgc agcaaatgac
2521 tactgcacct ggacagcctc ctcttttcta gaagtctatt tatattgtca ttttataaca
2581 ctctagcccc tgcccttatt gggggacaga tggtccctgt cctgcggggt ggccctggca
2641 gaaccactgc ctgaagaacc aggttcctgc ccggtcagcg cagccccagc ccgcccaccc
2701 ctgcctcgag ttagttttac aattaaaaca ttgtcttgtt taaaaaaaaa aaaaaaa
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