LOCUS BC011262 1968 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens phosphoglycerate dehydrogenase, mRNA (cDNA clone
MGC:18226 IMAGE:4156703), complete cds.
ACCESSION BC011262
VERSION BC011262.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1968)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1968)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (25-JUL-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: David N. Louis, M.D.
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Baylor College of Medicine Human Genome
Sequencing Center
Center code: BCM-HGSC
Web site: http://www.hgsc.bcm.tmc.edu/cdna/
Contact: amg@bcm.tmc.edu
Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
A.N., Gibbs, R.A.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 12 Row: e Column: 7
This clone was selected for full length sequencing because it
passed the following selection criteria: Hexamer frequency ORF
analysis.
FEATURES Location/Qualifiers
source 1..1968
/db_xref="H-InvDB:HIT000035203"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:18226 IMAGE:4156703"
/tissue_type="Brain, anaplastic oligodendroglioma with
1p/19q loss"
/clone_lib="NCI_CGAP_Brn67"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..1968
/gene="PHGDH"
/gene_synonym="3-PGDH"
/gene_synonym="3PGDH"
/gene_synonym="MGC3017"
/gene_synonym="PDG"
/gene_synonym="PGAD"
/gene_synonym="PGD"
/gene_synonym="PGDH"
/gene_synonym="SERA"
/db_xref="GeneID:26227"
/db_xref="HGNC:HGNC:8923"
/db_xref="MIM:606879"
CDS 137..1738
/gene="PHGDH"
/gene_synonym="3-PGDH"
/gene_synonym="3PGDH"
/gene_synonym="MGC3017"
/gene_synonym="PDG"
/gene_synonym="PGAD"
/gene_synonym="PGD"
/gene_synonym="PGDH"
/gene_synonym="SERA"
/codon_start=1
/product="phosphoglycerate dehydrogenase"
/protein_id="AAH11262.1"
/db_xref="GeneID:26227"
/db_xref="HGNC:HGNC:8923"
/db_xref="MIM:606879"
/translation="MAFANLRKVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAE
LQDCEGLIVRSATKVTADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGN
SLSAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREV
ATRMQSFGMKTIGYDPIISPEVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLN
DNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPPRDRALVDHE
NVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIG
LAEALGTLMRAWAGSPKGTIQVITQGTSLKNAGNCLSPAVIVGLLKEASKQADVNLVN
AKLLVKEAGLNVTTSHSPAAPGEQGFGECLLAVALAGAPYQAVGLVQGTTPVLQGLNG
AVFRPEVPLRRDLPLLLFRTQTSDPAMLPTMIGLLAEAGVRLLSYQTSLVSDGETWHV
MGISSLLPSLEAWKQHVTEAFQFHF"
BASE COUNT 469 a 531 c 581 g 387 t
ORIGIN
1 gaggaggagg aggagatgac tggggagcgg gagctcgaga atactgccca gttactctag
61 cgcgccaggc cgaaccgcag cttcttggct taggtacttc tactcacagc ggccgattcc
121 gaggccaact ccagcaatgg cttttgcaaa tctgcggaaa gtgctcatca gtgacagcct
181 ggacccttgc tgccggaaga tcttgcaaga tggagggctg caggtggtgg aaaagcagaa
241 ccttagcaaa gaggagctga tagcggagct gcaggactgt gaaggcctta ttgttcgctc
301 tgccaccaag gtgaccgctg atgtcatcaa cgcagctgag aaactccagg tggtgggcag
361 ggctggcaca ggtgtggaca atgtggatct ggaggccgca acaaggaagg gcatcttggt
421 tatgaacacc cccaatggga acagcctcag tgccgcagaa ctcacttgtg gaatgatcat
481 gtgcctggcc aggcagattc cccaggcgac ggcttcgatg aaggacggca aatgggagcg
541 gaagaagttc atgggaacag agctgaatgg aaagaccctg ggaattcttg gcctgggcag
601 gattgggaga gaggtagcta cccggatgca gtcctttggg atgaagacta tagggtatga
661 ccccatcatt tccccagagg tctcggcctc ctttggtgtt cagcagctgc ccctggagga
721 gatctggcct ctctgtgatt tcatcactgt gcacactcct ctcctgccct ccacgacagg
781 cttgctgaat gacaacacct ttgcccagtg caagaagggg gtgcgtgtgg tgaactgtgc
841 ccgtggaggg atcgtggacg aaggcgccct gctccgggcc ctgcagtctg gccagtgtgc
901 cggggctgca ctggacgtgt ttacggaaga gccgccacgg gaccgggcct tggtggacca
961 tgagaatgtc atcagctgtc cccacctggg tgccagcacc aaggaggctc agagccgctg
1021 tggggaggaa attgctgttc agttcgtgga catggtgaag gggaaatctc tcacgggggt
1081 tgtgaatgcc caggccctta ccagtgcctt ctctccacac accaagcctt ggattggtct
1141 ggcagaagct ctggggacac tgatgcgagc ctgggctggg tcccccaaag ggaccatcca
1201 ggtgataaca cagggaacat ccctgaagaa tgctgggaac tgcctaagcc ccgcagtcat
1261 tgtcggcctc ctgaaagagg cttccaagca ggcggatgtg aacttggtga acgctaagct
1321 gctggtgaaa gaggctggcc tcaatgtcac cacctcccac agccctgctg caccagggga
1381 gcaaggcttc ggggaatgcc tcctggccgt ggccctggca ggcgcccctt accaggctgt
1441 gggcttggtc caaggcacta cacctgtact gcaggggctc aatggagctg tcttcaggcc
1501 agaagtgcct ctccgcaggg acctgcccct gctcctattc cggactcaga cctctgaccc
1561 tgcaatgctg cctaccatga ttggcctcct ggcagaggca ggcgtgcggc tgctgtccta
1621 ccagacttca ctggtgtcag atggggagac ctggcacgtc atgggcatct cctccttgct
1681 gcccagcctg gaagcgtgga agcagcatgt gactgaagcc ttccagttcc acttctaacc
1741 ttggagctca ctggtccctg cctctggggc ttttctgaag aaacccaccc actgtgatca
1801 atagggagag aaaatccaca ttcttgggct gaacgcgggc ctctgacact gcttacactg
1861 cactctgacc ctgtagtaca gcaataaccg tctaataaag agcctacccc caaaaaaaaa
1921 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//