LOCUS BC010696 3497 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens proprotein convertase subtilisin/kexin type 7, mRNA
(cDNA clone MGC:17703 IMAGE:3868257), complete cds.
ACCESSION BC010696
VERSION BC010696.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3497)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3497)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (10-JUL-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Baylor College of Medicine Human Genome
Sequencing Center
Center code: BCM-HGSC
Web site: http://www.hgsc.bcm.tmc.edu/cdna/
Contact: amg@bcm.tmc.edu
Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
A.N., Gibbs, R.A.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 13 Row: h Column: 18
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 20336247.
FEATURES Location/Qualifiers
source 1..3497
/db_xref="H-InvDB:HIT000035049"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:17703 IMAGE:3868257"
/tissue_type="Eye, retinoblastoma"
/clone_lib="NIH_MGC_67"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..3497
/gene="PCSK7"
/gene_synonym="LPC"
/gene_synonym="PC7"
/gene_synonym="PC8"
/gene_synonym="SPC7"
/db_xref="GeneID:9159"
/db_xref="HGNC:HGNC:8748"
/db_xref="MIM:604872"
CDS 202..2559
/gene="PCSK7"
/gene_synonym="LPC"
/gene_synonym="PC7"
/gene_synonym="PC8"
/gene_synonym="SPC7"
/codon_start=1
/product="proprotein convertase subtilisin/kexin type 7"
/protein_id="AAH10696.1"
/db_xref="GeneID:9159"
/db_xref="HGNC:HGNC:8748"
/db_xref="MIM:604872"
/translation="MPKGRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLAGTGGP
DGQGTGGPSWAVHLESLEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPA
GHRPALEVEAIRQQVEAVLAGHEAVRWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRR
SPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMP
HPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNK
HYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHN
DNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDL
QKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEWV
TNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPRSLEV
LWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDP
NGFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRD
RQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFTVFWTVYY
MLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVETESRG
PPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGKEEQIC"
BASE COUNT 782 a 982 c 1032 g 701 t
ORIGIN
1 cactgctcct ccggctcccg ggaagccgcg agtttccgca gggaggcggc ggcagctgcg
61 gcggggccgg tctgtagcct ttgctgagtc aacactactc acagtgaaag tgatgccttt
121 tctccatttg cacaacatga gtgtgacgtg gttagccaga ccaggagctc aacctcatgt
181 agaatccagt ccactgctct gatgccgaag gggaggcaga aagtgccaca cttggatgcc
241 cccctgggcc tgcccacctg cctctggctg gaattagccg ggctcttctt actggttccc
301 tgggtcatgg gcctggcagg gacaggtggg cctgatggcc agggcacagg ggggccgagc
361 tgggctgtgc acctggaaag cctggaaggt gacggggagg aagagactct ggagcagcag
421 gcggatgcct tggcccaggc agcagggctg gtgaatgctg gacgcatcgg agagcttcag
481 gggcactacc tctttgtcca gcctgctggg cacaggccgg ccctggaggt ggaggccatc
541 cggcagcagg tggaggctgt gttggctggg catgaagctg tgcgctggca ctcagagcag
601 aggctgctaa ggcgggccaa gcgcagcgtc cacttcaacg accccaagta cccgcagcaa
661 tggcacctga ataaccgacg gagcccgggc agggacatca acgtgacggg tgtgtgggaa
721 cgcaatgtga ctgggcgagg ggtgacggtg gtggtagtgg atgacggagt ggaacacacc
781 atccaggaca ttgcacccaa ctatagccct gagggtagct atgacctcaa ctctaatgac
841 cctgacccca tgccccaccc ggatgtggag aatggcaacc accatggcac gcgatgtgca
901 ggagagatcg cggctgtgcc caacaacagc ttctgtgccg tgggcgtggc ctacgggagc
961 cgcatcgcag gtatccgggt actggatgga cctctcacag acagcatgga ggcagtggcg
1021 ttcaacaagc actatcagat caatgacatc tacagctgca gctggggacc agatgacgat
1081 gggaagacag tggatggccc ccatcagctt ggaaaggctg ccttacaaca tggggtgatt
1141 gctggtcgcc agggctttgg gagcatcttt gtggtagcca gtggcaacgg aggccaacac
1201 aacgacaact gcaactacga tggctacgcc aactccatct acaccgtcac cataggagct
1261 gtggatgagg agggacgcat gcctttctat gcagaagaat gtgcctccat gctggcagtc
1321 accttcagtg gtggggacaa gatgcttcgg agcattgtga ccactgactg ggaccttcag
1381 aagggcactg gctgcactga gggccacaca gggacctcag ctgcagcgcc tctggcagct
1441 ggcatgatag ccttaatgct gcaggtgcgg ccctgcctca cgtggcgtga cgtccagcac
1501 atcattgtct tcacagccac ccggtatgag gatcgccgtg cagagtgggt caccaacgag
1561 gcaggcttca gccatagcca ccagcacggt ttcggcctcc tcaacgcctg gaggctcgtg
1621 aatgcagcca agatctggac atctgtccct tacttagcat cctacgtcag tcccgtgtta
1681 aaagaaaaca aggcgattcc gcagtccccc cgttccctgg aggtcctgtg gaatgtcagc
1741 aggatggacc tggagatgtc agggctgaag accctggagc atgtggcagt gacagtctcc
1801 atcactcacc cacggcgcgg cagcttggag ctgaagctgt tctgccccag tggcatgatg
1861 tccctcatcg gcgccccccg cagcatggac tcggatccca acggcttcaa tgactggacc
1921 ttctccactg tgcgatgctg gggggagaga gcccgaggga cctacaggct tgtcatcagg
1981 gatgtcgggg atgagtcatt ccaggtcggc atcctccggc aatggcagct gaccctatat
2041 ggctctgtgt ggagtgcagt agacatcagg gacagacaaa ggctgttaga gagtgccatg
2101 agtggaaaat acctgcacga tgacttcgcc ctgccctgcc caccggggct gaaaattcct
2161 gaggaagatg gttacaccat cacccccaac accctcaaga ccctggtgct ggtaggctgt
2221 ttcaccgtct tctggactgt ttactacatg ctggaagtat atttgagcca gaggaatgtg
2281 gcttccaatc aagtttgtag gagtggaccc tgccactggc cccatcggag ccggaaagcc
2341 aaggaggaag ggacagagct agaatcagtg ccactttgca gcagcaagga tccagacgaa
2401 gtggaaacag agagcagggg ccctcccacc acctctgacc tccttgcccc agacctgctg
2461 gagcaagggg actggagcct gtcccagaac aagagcgccc tggactgccc tcatcagcac
2521 ctagacgtac cgcacgggaa ggaggagcag atctgctgac ctcagggcct gacagtgtgg
2581 gacaggctct tctttcccaa aattagggag ctcttgacag aaagcagttc tgatgcttac
2641 atctggaatc tgaggcatcc tctgactcca ctcaaagagg gtgagggcct tcttaagata
2701 caaatggtgg aggattgctg ccagagaagt ctggtcagag ccacagggtc tgcctccagc
2761 caaacgggag cttttggtga gaaggtgttg gacaggggat tggcgccccc ctttggtttg
2821 gcctccatcc tcatctctct tgggccaagc cagctgccta ggtcccccaa gcatggggga
2881 ccccttccca catataagtt gagaaggtgc ctgccatagc caggagcgca tctcaatgga
2941 aacatcactg gggtcacttg ggaagaggac ttcggggtag aggctgggag gagcccctgg
3001 acatgcctgt cctgaaagcg gctgcctcca ttatccattc ccaagatgcc tgatcagaaa
3061 ccaaccatga atgaacccct ggctccttca ccacccccac gattggtatg atgctgccgg
3121 cacagctggg atacacacgg ctcccccagg cctgagctgc ttcactaggg aatcctgcgg
3181 caggactgca gagcagatgg cagatgcaca tgttggagga gagagccttg ggagccactg
3241 ccactccagt cctgccacca ccctgtcttc ctctgcaagt gctcagggaa atggccttcc
3301 cgccggaggc cagctatctg cctgacaggc tgtgactctt ctctcaacct tggccttctc
3361 ccctcttctg agctagttgg ttgaattttt tttaatgctt aagatttgtt tttctctttt
3421 cacagcaaca ttttcttgaa tttttttctg cacagctttt ccaaaataaa aaccttccaa
3481 acaaaaaaaa aaaaaaa
//