LOCUS BC010674 3619 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens protein tyrosine phosphatase, non-receptor type 4
(megakaryocyte), mRNA (cDNA clone MGC:9204 IMAGE:3853914), complete
cds.
ACCESSION BC010674
VERSION BC010674.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3619)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3619)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (10-JUL-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Baylor College of Medicine Human Genome
Sequencing Center
Center code: BCM-HGSC
Web site: http://www.hgsc.bcm.tmc.edu/cdna/
Contact: amg@bcm.tmc.edu
Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
A.N., Gibbs, R.A.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 13 Row: b Column: 15
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 18104987.
FEATURES Location/Qualifiers
source 1..3619
/db_xref="H-InvDB:HIT000035043"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:9204 IMAGE:3853914"
/tissue_type="Colon, adenocarcinoma"
/clone_lib="NIH_MGC_65"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..3619
/gene="PTPN4"
/gene_synonym="PTPMEG"
/gene_synonym="PTPMEG1"
/db_xref="GeneID:5775"
/db_xref="HGNC:HGNC:9656"
/db_xref="MIM:176878"
CDS 428..3208
/gene="PTPN4"
/gene_synonym="PTPMEG"
/gene_synonym="PTPMEG1"
/codon_start=1
/product="protein tyrosine phosphatase, non-receptor type
4 (megakaryocyte)"
/protein_id="AAH10674.1"
/db_xref="GeneID:5775"
/db_xref="HGNC:HGNC:9656"
/db_xref="MIM:176878"
/translation="MTSRFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFK
VNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYS
LNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGD
YDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAEFNYLNTARTLELYG
VEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCKQFFIQLRKEL
HESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKNFFAHYFTLGSKFRYC
GRTEVQSVQYGKEKANKDRVFARSPSKPLARKLMDWEVVSRNSISDDRLETQSLPSRS
PPGTPNHRNSTFTQEGTRLRPSSVGHLVDHMVHTSPSEVFVNQRSPSSTQANSIVLES
SPSQETPGDGKPPALPPKQSKKNSWNQIHYSHSQQDLESHINETFDIPSSPEKPTPNG
GIPHDNLVLIRMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRLNEGDQV
VLINGRDIAEHTHDQVVLFIKASCERHSGELMLLVRPNAVYDVVEEKLENEPDFQYIP
EKAPLDSVHQDDHSLRESMIQLAEGLITGTVLTQFDQLYRKKPGMTMSCAKLPQNISK
NRYRDISPYDATRVILKGNEDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQM
TWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKMT
LFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGI
GRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEE
GFVKPLTTSTNK"
BASE COUNT 1116 a 762 c 789 g 952 t
ORIGIN
1 caccaccaac attgttctct caggactcct gggtcccagg ggccggaatt gggcctgagc
61 gggagaggaa agagacttgg ctttggccgc ggggtcggag gattggggcc aggccccctc
121 ccccacgcac ttttgggggt gtggattatc tcatccctgc agggaggtag gagaggtcgc
181 cggctgcccg cctccctgcc acctccccag cggcgccggc ccgcggctgc ccagcagcat
241 gaggtggtgc tggcggctcc gggtcgtggc gcgaccgctg cggcggcggc tgctcggggg
301 gcgctgaggt agccccccgg agcggcacgg aggacgcgct tctcctctgc gcgccggggc
361 ctcgaggctt tttttctcca gccgagagga cgcggctgtg atatacgaag actttgtgtg
421 gacagtaatg acctcacgtt tccgattgcc tgctggcaga acctacaatg tacgagcatc
481 agagttggcc cgagacagac agcatactga agtggtttgc aacatccttc ttctggataa
541 cactgtacaa gctttcaaag tcaataaaca tgatcagggg caagtcttgt tggatgtcgt
601 cttcaagcat ctagatttga ctgagcagga ctattttggt ttacagttgg ctgatgattc
661 cacagataac ccaaggtggc tggatccaaa caaaccaata aggaagcagc taaagagagg
721 atctccttac agtttgaact ttagagtcaa attttttgta agtgacccca acaagttaca
781 agaagaatat acaaggtacc agtatttttt gcaaattaaa caagacattc ttactggaag
841 attaccctgt ccttctaata ctgctgccct tttagcttca tttgctgttc agtctgaact
901 tggagactac gatcagtcag agaacttgtc aggctacctc tcagattatt ctttcattcc
961 taatcaacct caagattttg aaaaagaaat tgcaaaatta catcagcaac acataggctt
1021 atctcctgca gaagcagaat ttaattacct aaacacagca cgtaccttag aactctatgg
1081 agttgaattc cactatgcaa gggatcagag taacaatgaa attatgattg gagtgatgtc
1141 aggaggaatt ctgatttata agaacagggt acgaatgaat acctttccat ggttgaagat
1201 tgtaaaaatt tcttttaagt gcaaacagtt ttttattcaa cttagaaaag aattgcatga
1261 atctagagaa acattattgg gatttaatat ggtgaattac agagcatgta aaaatttgtg
1321 gaaagcatgt gtagaacatc acacattctt ccgtttggac agaccacttc cacctcaaaa
1381 gaattttttt gcacattatt ttacattagg ttcaaaattc cggtactgtg ggagaactga
1441 agtccaatca gttcagtatg gcaaagaaaa ggcaaataaa gacagggtat ttgcaagatc
1501 cccaagtaag cccttggcac ggaaattaat ggattgggaa gtagtaagca gaaattcaat
1561 atctgatgac aggttagaaa cacaaagtct tccatcacga tctccaccgg gaactcctaa
1621 tcatcgaaat tctacattca cgcaggaagg aacccggtta cgaccatctt cagttggtca
1681 tttggtagac catatggttc atacttcccc aagcgaagtg tttgtaaatc agagatctcc
1741 gtcatcaaca caagctaata gcattgttct ggaatcatca ccatcacaag agacccctgg
1801 agatgggaag cctccagctt taccacccaa acagtcaaag aaaaacagtt ggaaccaaat
1861 tcattattca cattcgcaac aagatctaga aagtcatatt aatgaaacat ttgatattcc
1921 atcttctcct gaaaaaccca ctcctaatgg tggtattcca catgataatc ttgtcctaat
1981 cagaatgaaa cctgatgaaa atgggaggtt tggattcaat gtaaagggag gatatgatca
2041 gaagatgcct gtgattgtgt ctcgagtagc accaggaaca cctgctgacc tctgtgtccc
2101 tagactgaat gaaggggacc aagttgtact gatcaatggt cgggacattg cagaacacac
2161 tcatgatcag gttgtgctgt ttattaaagc tagttgtgag agacattctg gggaactcat
2221 gcttctagtt cgacctaatg ctgtatatga tgtagtggaa gaaaagctag aaaatgagcc
2281 agatttccag tatattcctg agaaagcccc actagatagt gtgcatcagg atgaccattc
2341 cctgcgggag tcaatgatcc agctagctga ggggcttatc actggaacag tcctgacaca
2401 gtttgatcaa ctgtatcgga aaaaacctgg aatgacaatg tcctgtgcca aattacctca
2461 gaatatttcc aaaaatagat acagagatat ttcgccttat gatgccacac gggtcatttt
2521 aaaaggtaat gaagactaca tcaatgcgaa ctatataaat atggaaattc cttcttccag
2581 cattataaat cagtacattg cttgtcaagg gccattacca cacacttgta cagatttttg
2641 gcagatgact tgggaacaag gctcctctat ggttgtaatg ttgaccacac aagttgaacg
2701 tggcagagtt aaatgtcacc aatattggcc agaacccaca ggcagttcat cttatggatg
2761 ctaccaagtt acctgccact ctgaagaagg aaacactgcc tatatcttca ggaagatgac
2821 cctatttaac caagagaaaa atgaaagtcg tccactcact cagatccagt acatagcctg
2881 gcctgaccat ggagtccctg atgattcgag tgactttcta gattttgttt gtcatgtacg
2941 aaacaagagg gctggcaagg aagaacccgt tgttgtccat tgcagtgctg gaatcggaag
3001 aactggggtt cttattacta tggaaacagc catgtgtctc attgaatgca atcagccagt
3061 ttatccacta gatattgtaa gaacaatgag agatcagcga gccatgatga tccaaacacc
3121 tagtcaatac agatttgtat gtgaagctat tttgaaagtt tatgaagaag gctttgttaa
3181 acccttaaca acatcaacaa ataaataaga aagcaaaaag atctgggata tgtgttggaa
3241 aactgctttc ccttatgttc actgtgccat aatgctgctc gcaggaaatg gcattttaca
3301 aaaaaaaaat gaagaactca aaaaaacttt gaaaacttca gcactgttgc actttatgtt
3361 ttaaaaaatg tcactctttc aaaatctata actcatgtat ttgaagactg tttcatgctt
3421 tgctccgaac aaatagtaaa taactgagta tgttcagggt aatttatgaa attttgtggt
3481 ggtgccatgc aatccccttt tggtagaatt gccacaaaca aggctcaaaa ttctcatcat
3541 ctctgttata cacctgtatc atgaaagcaa aaagaagtaa acatcaggag tcagctctga
3601 aaaaaaaaaa aaaaaaaaa
//