LOCUS BC010530 1592 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens serpin peptidase inhibitor, clade A (alpha-1
antiproteinase, antitrypsin), member 3, mRNA (cDNA clone MGC:18102
IMAGE:4152174), complete cds.
ACCESSION BC010530
VERSION BC010530.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1592)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1592)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (10-JUL-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: David N. Louis, M.D.
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Baylor College of Medicine Human Genome
Sequencing Center
Center code: BCM-HGSC
Web site: http://www.hgsc.bcm.tmc.edu/cdna/
Contact: amg@bcm.tmc.edu
Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
A.N., Gibbs, R.A.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 19 Row: i Column: 22
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 50659079.
FEATURES Location/Qualifiers
source 1..1592
/db_xref="H-InvDB:HIT000034984"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:18102 IMAGE:4152174"
/tissue_type="Brain, glioblastoma with EGFR amplification"
/clone_lib="NCI_CGAP_Brn64"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..1592
/gene="SERPINA3"
/gene_synonym="ACT"
/gene_synonym="GIG24"
/gene_synonym="GIG25"
/db_xref="GeneID:12"
/db_xref="HGNC:HGNC:16"
/db_xref="MIM:107280"
CDS 50..1321
/gene="SERPINA3"
/gene_synonym="ACT"
/gene_synonym="GIG24"
/gene_synonym="GIG25"
/codon_start=1
/product="serpin peptidase inhibitor, clade A (alpha-1
antiproteinase, antitrypsin), member 3"
/protein_id="AAH10530.1"
/db_xref="GeneID:12"
/db_xref="HGNC:HGNC:16"
/db_xref="MIM:107280"
/translation="MERMLPLLALGLLAAGFCPAVLCHPNSPLDEENLTQENQDRGTH
VDLGLASANVDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKG
LKFNLTETSEAEIHQSFQHLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRL
YGSEAFATDFQDSAAAKKLINDYVKNGTRGKITDLIKDLDSQTMMVLVNYIFFKAKWE
MPFDPQDTHQSRFYLSKKKWVMVPMMSLHHLTIPYFRDEELSCTVVELKYTGNASALF
ILPDQDKMEEVEAMLLPETLKRWRDSLEFREIGELYLPKFSISRDYNLNDILLQLGIE
EAFTSKADLSGITGARNLAVSQVVHKAVLDVFEEGTEASAATAVKITLLSALVETRTI
VRFNRPFLMIIVPTDTQNIFFMSKVTNPKQA"
BASE COUNT 415 a 429 c 401 g 347 t
ORIGIN
1 ggctttggaa tccaccagct acatccagct ccctgaggca gagttgagaa tggagagaat
61 gttacctctc ctggctctgg ggctcttggc ggctgggttc tgccctgctg tcctctgcca
121 ccctaacagc ccacttgacg aggagaatct gacccaggag aaccaagacc gagggacaca
181 cgtggacctc ggattagcct ccgccaacgt ggacttcgct ttcagcctgt acaagcagtt
241 agtcctgaag gcccctgata agaatgtcat cttctcccca ctgagcatct ccaccgcctt
301 ggccttcctg tctctggggg cccataatac caccctgaca gagattctca aaggcctcaa
361 gttcaacctc acggagactt ctgaggcaga aattcaccag agcttccagc acctcctgcg
421 caccctcaat cagtccagcg atgagctgca gctgagtatg ggaaatgcca tgtttgtcaa
481 agagcaactc agtctgctgg acaggttcac ggaggatgcc aagaggctgt atggctccga
541 ggcctttgcc actgactttc aggactcagc tgcagctaag aagctcatca acgactacgt
601 gaagaatgga actaggggga aaatcacaga tctgatcaag gaccttgact cgcagacaat
661 gatggtcctg gtgaattaca tcttctttaa agccaaatgg gagatgccct ttgaccccca
721 agatactcat cagtcaaggt tctacttgag caagaaaaag tgggtaatgg tgcccatgat
781 gagtttgcat cacctgacta taccttactt ccgggacgag gagctgtcct gcaccgtggt
841 ggagctgaag tacacaggca atgccagcgc actcttcatc ctccctgatc aagacaagat
901 ggaggaagtg gaagccatgc tgctcccaga gaccctgaag cggtggagag actctctgga
961 gttcagagag ataggtgagc tctacctgcc aaagttttcc atctcgaggg actataacct
1021 gaacgacata cttctccagc tgggcattga ggaagccttc accagcaagg ctgacctgtc
1081 agggatcaca ggggccagga acctagcagt ctcccaggtg gtccataagg ctgtgcttga
1141 tgtatttgag gagggcacag aagcatctgc tgccacagca gtcaaaatca ccctcctttc
1201 tgcattagtg gagacaagga ccattgtgcg tttcaacagg cccttcctga tgatcattgt
1261 ccctacagac acccagaaca tcttcttcat gagcaaagtc accaatccca agcaagccta
1321 gagcttgcca tcaagcagtg gggctctcag taaggaactt ggaatgcaag ctggatgcct
1381 gggtctctgg gcacagcctg gcccctgtgc accgagtggc catggcatgt gtggccctgt
1441 ctgcttatcc ttggaaggtg acagcgattc cctgtgtagc tctcacatgc acaggggccc
1501 atggactctt cagtctggag ggtcctgggc ctcctgacag caataaataa tttcgttgga
1561 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
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