LOCUS BC010504 1742 bp mRNA linear HUM 26-APR-2004 DEFINITION Homo sapiens DDHD domain containing 2, mRNA (cDNA clone MGC:16854 IMAGE:3451888), complete cds. ACCESSION BC010504 VERSION BC010504.1 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1742) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 1742) AUTHORS Strausberg,R. TITLE Direct Submission JOURNAL Submitted (10-JUL-2001) National Institutes of Health, Mammalian Gene Collection (MGC), Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: ATCC cDNA Library Preparation: Life Technologies, Inc. cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: Baylor College of Medicine Human Genome Sequencing Center Center code: BCM-HGSC Web site: http://www.hgsc.bcm.tmc.edu/cdna/ Contact: amg@bcm.tmc.edu Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H., Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati, A.N., Gibbs, R.A. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAK Plate: 19 Row: c Column: 19. FEATURES Location/Qualifiers source 1..1742 /db_xref="H-InvDB:HIT000034973" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:16854 IMAGE:3451888" /tissue_type="Placenta, choriocarcinoma" /clone_lib="NIH_MGC_10" /lab_host="DH10B" /note="Vector: pCMV-SPORT6" gene 1..1742 /gene="DDHD2" /gene_synonym="KIAA0725" /db_xref="GeneID:23259" CDS 327..1484 /gene="DDHD2" /gene_synonym="KIAA0725" /codon_start=1 /product="DDHD2 protein" /protein_id="AAH10504.1" /db_xref="GeneID:23259" /translation="MNRIYTLFLQRNPDFKGGVSIAGHSLGSLILFDILTNQKDSLGD IDSEKDSLNIVMDQGDTPTLEEDLKKLQLSEFFDIFEKEKVDKEALALCTDRDLQEIG IPLGPRKKILNYFSTRKNSMGIKRPAPQPASGANIPKESEFCSSSNTRNGDYLDVGIG QVSVKYPRLIYKPEIFFAFGSPIGMFLTVRGLKRIDPNYRFPTCKGFFNIYHPFDPVA YRIEPMVVPGVEFEPMLIPHHKGRKRMHLELREGLTRMSMDLKNNLLGSLRMAWKSFT RAPYPALQASETPEETEAEPESTSEKPSDVNTEETSVAVKEEVLPINVGMLNGGQRID YVLQEKPIESFNEYLFALQSHLCYWESEDTVLLVLKEIYQTQGIFLDQPLQ" misc_feature 492..686 /gene="DDHD2" /gene_synonym="KIAA0725" /note="SAM; Region: Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation" /db_xref="CDD:smart00454" misc_feature 831..1448 /gene="DDHD2" /gene_synonym="KIAA0725" /note="DDHD; Region: DDHD domain. The DDHD domain is 180 residues long and contains four conserved residues that may form a metal binding site. The domain is named after these four residues. This pattern of conservation of metal binding residues is often seen in phosphoesterase domains. This domain is found in retinal degeneration B proteins, as well as a family of probable phospholipases. It has been shown that this domain is found in a longer C terminal region that binds to PYK2 tyrosine kinase. These proteins have been called N-terminal domain-interacting receptor (Nir1, Nir2 and Nir3). This suggests that this region is involved in functionally important interactions in other members of this family" /db_xref="CDD:pfam02862" BASE COUNT 518 a 372 c 371 g 481 t ORIGIN 1 gtgcagtcca tgggattgga ccagcttgtg atctccgctt tcgaagcatt gtacagtgtg 61 ttaatgattt tcgcagtgtt tccttgaact tgctacagac acattttaag aaagcccaag 121 aaaatcagca gattgggagg gtagaatttc ttccagtcaa ctggcacagt cctttgcatt 181 ctactggtgt ggatgtagat ctgcagcgaa taaccctgcc cagcattaac cgcctcaggc 241 acttcaccaa tgacacaatt ctggatgtct tcttctacaa tagtcccacc tactgtcaga 301 ctattgtgga cacagttgct tctgaaatga accgaatata cacacttttt ctacagagga 361 accctgattt caaagggggt gtatccattg ctggtcatag tttaggttcg cttatattgt 421 ttgatatcct aacaaatcag aaagattctt tgggggatat tgacagtgaa aaggattcgc 481 taaatattgt aatggatcaa ggagatacac ctacactaga ggaagatttg aagaaacttc 541 agctctctga attctttgat atctttgaga aggagaaagt agataaggaa gctctggctt 601 tatgtacaga ccgagatctt caggaaatag gaattccttt aggaccaaga aagaagatat 661 taaactattt cagcaccaga aaaaactcaa tgggtattaa gagaccagcc ccgcagcctg 721 cttcaggggc aaacatcccc aaagaatctg agttctgcag tagcagtaat actagaaatg 781 gtgactatct ggatgttggc attgggcagg tgtctgtgaa atacccccgg ctcatctata 841 aaccagagat attctttgcc tttggatctc ccattggaat gttccttact gtccgaggac 901 taaaaagaat tgatcccaac tacagatttc caacgtgcaa aggtttcttc aatatttatc 961 acccttttga tcctgtggcc tataggattg aaccaatggt ggtcccagga gtggaatttg 1021 agccaatgct gatcccacat cataaaggca ggaagcggat gcacttagaa ctgagagagg 1081 gcttgaccag gatgagtatg gaccttaaga acaacttgct aggttcgctg cggatggcct 1141 ggaagtcttt taccagagct ccataccctg ccttacaagc ttcagaaaca ccagaagaaa 1201 ctgaagcaga acctgaatca acttcagaga agcctagtga tgttaacaca gaagagacct 1261 ctgtggcagt taaagaagaa gtcctgccta tcaatgtggg gatgctgaat ggaggccaac 1321 gcattgacta tgtgctacag gagaagccta ttgaaagttt taatgagtat ttatttgctt 1381 tacaaagcca tctatgctac tgggagtctg aagatacagt attgctcgtc ctcaaagaga 1441 tctaccaaac ccagggtatc ttccttgatc agcctttaca gtaaaaatga cccatctatg 1501 gctgcttaat acggacattg agggatcctt ccccagaaaa tccacctgtt tgttgctgca 1561 attttcctct cctcagctgc gtcatttcct gcatgttgcc tgccacttac tcaccactgg 1621 ggtctttgga agataatctt cctctttgga aatgaatgga aaagcaaaag gccctattac 1681 ttttaaccac tggcttcata taaacacttg ccattttttt ctgcataaaa aaaaaaaaaa 1741 aa //