LOCUS BC010504 1742 bp mRNA linear HUM 26-APR-2004
DEFINITION Homo sapiens DDHD domain containing 2, mRNA (cDNA clone MGC:16854
IMAGE:3451888), complete cds.
ACCESSION BC010504
VERSION BC010504.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1742)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1742)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (10-JUL-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Baylor College of Medicine Human Genome
Sequencing Center
Center code: BCM-HGSC
Web site: http://www.hgsc.bcm.tmc.edu/cdna/
Contact: amg@bcm.tmc.edu
Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
A.N., Gibbs, R.A.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 19 Row: c Column: 19.
FEATURES Location/Qualifiers
source 1..1742
/db_xref="H-InvDB:HIT000034973"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:16854 IMAGE:3451888"
/tissue_type="Placenta, choriocarcinoma"
/clone_lib="NIH_MGC_10"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..1742
/gene="DDHD2"
/gene_synonym="KIAA0725"
/db_xref="GeneID:23259"
CDS 327..1484
/gene="DDHD2"
/gene_synonym="KIAA0725"
/codon_start=1
/product="DDHD2 protein"
/protein_id="AAH10504.1"
/db_xref="GeneID:23259"
/translation="MNRIYTLFLQRNPDFKGGVSIAGHSLGSLILFDILTNQKDSLGD
IDSEKDSLNIVMDQGDTPTLEEDLKKLQLSEFFDIFEKEKVDKEALALCTDRDLQEIG
IPLGPRKKILNYFSTRKNSMGIKRPAPQPASGANIPKESEFCSSSNTRNGDYLDVGIG
QVSVKYPRLIYKPEIFFAFGSPIGMFLTVRGLKRIDPNYRFPTCKGFFNIYHPFDPVA
YRIEPMVVPGVEFEPMLIPHHKGRKRMHLELREGLTRMSMDLKNNLLGSLRMAWKSFT
RAPYPALQASETPEETEAEPESTSEKPSDVNTEETSVAVKEEVLPINVGMLNGGQRID
YVLQEKPIESFNEYLFALQSHLCYWESEDTVLLVLKEIYQTQGIFLDQPLQ"
misc_feature 492..686
/gene="DDHD2"
/gene_synonym="KIAA0725"
/note="SAM; Region: Sterile alpha motif. Widespread domain
in signalling and nuclear proteins. In EPH-related
tyrosine kinases, appears to mediate cell-cell initiated
signal transduction via the binding of SH2-containing
proteins to a conserved tyrosine that is phosphorylated.
In many cases mediates homodimerisation"
/db_xref="CDD:smart00454"
misc_feature 831..1448
/gene="DDHD2"
/gene_synonym="KIAA0725"
/note="DDHD; Region: DDHD domain. The DDHD domain is 180
residues long and contains four conserved residues that
may form a metal binding site. The domain is named after
these four residues. This pattern of conservation of metal
binding residues is often seen in phosphoesterase domains.
This domain is found in retinal degeneration B proteins,
as well as a family of probable phospholipases. It has
been shown that this domain is found in a longer C
terminal region that binds to PYK2 tyrosine kinase. These
proteins have been called N-terminal domain-interacting
receptor (Nir1, Nir2 and Nir3). This suggests that this
region is involved in functionally important interactions
in other members of this family"
/db_xref="CDD:pfam02862"
BASE COUNT 518 a 372 c 371 g 481 t
ORIGIN
1 gtgcagtcca tgggattgga ccagcttgtg atctccgctt tcgaagcatt gtacagtgtg
61 ttaatgattt tcgcagtgtt tccttgaact tgctacagac acattttaag aaagcccaag
121 aaaatcagca gattgggagg gtagaatttc ttccagtcaa ctggcacagt cctttgcatt
181 ctactggtgt ggatgtagat ctgcagcgaa taaccctgcc cagcattaac cgcctcaggc
241 acttcaccaa tgacacaatt ctggatgtct tcttctacaa tagtcccacc tactgtcaga
301 ctattgtgga cacagttgct tctgaaatga accgaatata cacacttttt ctacagagga
361 accctgattt caaagggggt gtatccattg ctggtcatag tttaggttcg cttatattgt
421 ttgatatcct aacaaatcag aaagattctt tgggggatat tgacagtgaa aaggattcgc
481 taaatattgt aatggatcaa ggagatacac ctacactaga ggaagatttg aagaaacttc
541 agctctctga attctttgat atctttgaga aggagaaagt agataaggaa gctctggctt
601 tatgtacaga ccgagatctt caggaaatag gaattccttt aggaccaaga aagaagatat
661 taaactattt cagcaccaga aaaaactcaa tgggtattaa gagaccagcc ccgcagcctg
721 cttcaggggc aaacatcccc aaagaatctg agttctgcag tagcagtaat actagaaatg
781 gtgactatct ggatgttggc attgggcagg tgtctgtgaa atacccccgg ctcatctata
841 aaccagagat attctttgcc tttggatctc ccattggaat gttccttact gtccgaggac
901 taaaaagaat tgatcccaac tacagatttc caacgtgcaa aggtttcttc aatatttatc
961 acccttttga tcctgtggcc tataggattg aaccaatggt ggtcccagga gtggaatttg
1021 agccaatgct gatcccacat cataaaggca ggaagcggat gcacttagaa ctgagagagg
1081 gcttgaccag gatgagtatg gaccttaaga acaacttgct aggttcgctg cggatggcct
1141 ggaagtcttt taccagagct ccataccctg ccttacaagc ttcagaaaca ccagaagaaa
1201 ctgaagcaga acctgaatca acttcagaga agcctagtga tgttaacaca gaagagacct
1261 ctgtggcagt taaagaagaa gtcctgccta tcaatgtggg gatgctgaat ggaggccaac
1321 gcattgacta tgtgctacag gagaagccta ttgaaagttt taatgagtat ttatttgctt
1381 tacaaagcca tctatgctac tgggagtctg aagatacagt attgctcgtc ctcaaagaga
1441 tctaccaaac ccagggtatc ttccttgatc agcctttaca gtaaaaatga cccatctatg
1501 gctgcttaat acggacattg agggatcctt ccccagaaaa tccacctgtt tgttgctgca
1561 attttcctct cctcagctgc gtcatttcct gcatgttgcc tgccacttac tcaccactgg
1621 ggtctttgga agataatctt cctctttgga aatgaatgga aaagcaaaag gccctattac
1681 ttttaaccac tggcttcata taaacacttg ccattttttt ctgcataaaa aaaaaaaaaa
1741 aa
//