LOCUS BC010273 3322 bp mRNA linear HUM 16-DEC-2006
DEFINITION Homo sapiens phosphoribosylaminoimidazole carboxylase,
phosphoribosylaminoimidazole succinocarboxamide synthetase, mRNA
(cDNA clone MGC:5024 IMAGE:2900848), complete cds.
ACCESSION BC010273
VERSION BC010273.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3322)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3322)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (05-JUL-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Baylor College of Medicine Human Genome
Sequencing Center
Center code: BCM-HGSC
Web site: http://www.hgsc.bcm.tmc.edu/cdna/
Contact: amg@bcm.tmc.edu
Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
A.N., Gibbs, R.A.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 3 Row: k Column: 17
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 17388802.
FEATURES Location/Qualifiers
source 1..3322
/db_xref="H-InvDB:HIT000034875"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:5024 IMAGE:2900848"
/tissue_type="Placenta, choriocarcinoma"
/clone_lib="NIH_MGC_10"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..3322
/gene="PAICS"
/gene_synonym="ADE2"
/gene_synonym="ADE2H1"
/gene_synonym="AIRC"
/gene_synonym="MGC1343"
/gene_synonym="MGC5024"
/db_xref="GeneID:10606"
/db_xref="HGNC:HGNC:8587"
/db_xref="MIM:172439"
CDS 206..1483
/gene="PAICS"
/gene_synonym="ADE2"
/gene_synonym="ADE2H1"
/gene_synonym="AIRC"
/gene_synonym="MGC1343"
/gene_synonym="MGC5024"
/codon_start=1
/product="phosphoribosylaminoimidazole carboxylase,
phosphoribosylaminoimidazole succinocarboxamide
synthetase"
/protein_id="AAH10273.1"
/db_xref="GeneID:10606"
/db_xref="HGNC:HGNC:8587"
/db_xref="MIM:172439"
/translation="MATAEVLNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNA
ARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTRKCGETAFIAPQCEMIPIEWVCRR
IATGSFLKRNPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKFCFAGLLIGQT
EVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWP
SGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVAERVELLLKSESQCRVVVLMGSTS
DLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNG
LGPVMSGNTAYPVISCPPLTPDWGVQDVWSSLRLPSGLGCSTVLSPEGSAQFAAQIFG
LSNHLVWSKLRASILNTWISLKQADKKIRECNL"
BASE COUNT 960 a 721 c 683 g 958 t
ORIGIN
1 gaaagctgta tttgctgcac gtggaaatct ccgttatttt ccagcaccca acagtagcgt
61 aatgggagta acggacttaa cctcatttct ctttcagagc atttagcctt catatgccct
121 tccctgcatg cttcccccag gccgtcaaga cttgagttct gcctcgcttc ccggcgcggt
181 cgcagccctc agcccactta ggataatggc gacagctgag gtactgaaca ttggtaaaaa
241 attatatgag ggtaaaacaa aagaagtcta cgaattgtta gacagtccag gaaaagtcct
301 cctgcagtcc aaggaccaga ttacagcagg aaatgcagct agaaaaaacc acctggaagg
361 aaaagctgca atctcaaata aaatcaccag ttgtattttt cagttattac aggaagcagg
421 tattaaaact gccttcacca gaaaatgtgg ggagacagct ttcattgcac cgcagtgtga
481 aatgattcca attgaatggg tttgcagaag aatagcaact ggttcttttc tcaaaagaaa
541 tcctggtgtc aaggaaggat ataagtttta cccacctaaa gtggagttgt ttttcaagga
601 tgatgccaat aatgacccac agtggtctga ggaacagctg attgctgcaa aattttgctt
661 tgctggactt cttataggcc agactgaagt ggatatcatg agtcatgcta cacaggctat
721 atttgaaata ctggagaaat cctggttgcc ccagaattgt acactggttg atatgaagat
781 tgaatttggt gttgatgtaa ccaccaaaga aattgttctt gctgatgtta ttgacaatga
841 ttcctggaga ctctggccat caggagatcg aagccaacag aaagacaaac agtcttatcg
901 ggacctcaaa gaagtaactc ctgaagggct ccaaatggta aagaaaaact ttgagtgggt
961 tgcagagaga gtagagttgc ttttgaaatc agaaagtcag tgcagggttg tagtgttgat
1021 gggctctact tctgatcttg gtcactgtga aaaaatcaag aaggcctgtg gaaattttgg
1081 cattccatgt gaacttcgag taacatctgc gcataaagga ccagatgaaa ctctgaggat
1141 taaagctgag tatgaagggg atggcattcc tactgtattt gtggcagtgg caggcagaag
1201 taatggtttg ggaccagtga tgtctgggaa cactgcatat ccagttatca gctgtcctcc
1261 cctcacacca gactggggag ttcaggatgt gtggtcttct cttcgactac ccagtggtct
1321 tggctgttca accgtacttt ctccagaagg atcagctcaa tttgctgctc agatatttgg
1381 gttaagcaac catttggtat ggagcaaact gcgagcaagc attttgaaca catggatttc
1441 cttgaagcag gctgacaaga aaatcagaga atgtaattta taagaaagaa tgccattgaa
1501 ttttttaggg gaaaaactac aaatttctaa tttagctgaa ggaaaatcaa gcaagatgaa
1561 aaggtaattt taaattagag aacacaaata aaatgtatta gtgaataaat gcttctctag
1621 atccatatta ataaacatga gcatctaacc cctcctttct taggctagac accaagatat
1681 ttcagccagc ctttatcatt cctcttactt tatccttttt ccttaagtat tggtggtcac
1741 tactattgag tttcttcctt aacactgatt aaatgatctt aactccctca gctaaaactg
1801 gcattactga ctcccagcta tatttctcca gacttgcatt tttttttttt tttttgagac
1861 agggtctcac tgtcgcccag gctggagtgc agtggcgtga tctcagttca ctgctgcttt
1921 ccctcctggg ctcaagcagt tctcccacct cagcctctcg actaacaggg actataatct
1981 tgcagcacca tgccgagcta attttatttt ttgtagagat gagctctcac tatgtcaccc
2041 aggttcgtct caaactcctg aaccctagta attctcctat ctcagcctcc caaagtgcta
2101 gggttacaga catgagccac tgtgcctgtc tagacttgta ctttcaactg tccatttctc
2161 cctgtctgtc ccatgggcac tcatgaaaaa acagaatgct cccaacttta ttcatcttcc
2221 aagcctgtag ctcttggtat actcactgtt gcaagtcaga agcttgattt catcattgat
2281 gtttttctca cgtttcacat ctcactcatc accaagtcat gttggtgtta atttctgatt
2341 aacccttgaa tttaccgtct tctcatcctc tgtacaaaag cctcaagtga gggtcaaatt
2401 caacattatc ctgatctaga cagcccccat tctcaatcca cccttttcca agttgattgc
2461 ccaaggactt ctaacaataa actctctttt gcaccacaga cttctttgaa aatatacatg
2521 ctgttgaccc tctctgtaga aaaccgcaca cataaaactt accaacagat ttcattggtt
2581 cttgggttct cccgaagcct atccatggtt tatagattaa gaattgatga ggtagctggg
2641 cacagtggct cacacctacg atcacagcac ttcgggaggc tgaagcaagc agatcacttg
2701 aggtcaggag tttgagacca gcctggccaa catggtgaaa ccctgtctct actaaaaata
2761 caaaaagtag ccagccgtga tgacaggcac ctgtaatccc agctactcgg gaggctgagg
2821 catgagaatt gcttgaaccc gggaggcgga ggttgcagtg agcctggatc atgccactgc
2881 actccaacct gggcagcaga gcaagactct gtctcaaaag gggaaaaaaa aaattgctga
2941 tgtgacccat gaagggaact cattttcctc gtaattttgg actgccacac attggtacct
3001 ttagttctct gaaggcccac gtttttatca ttaagaccta tttgttagct agtagagctt
3061 tatgttcgct gtccatgaaa ccttctgtaa ccacagtgac tacaagtagt tctttctcta
3121 ttgaattatt aggtccagaa tagaagatgt cattgtacac tttatttccc tcacactgtg
3181 ttatgctctg atgtgctatg cttagctatc tgtcagagat tagtaaatta taaaactcat
3241 gtgtactact taagtttata tcttatgcta gtttataaga acaattaaaa ggacttagaa
3301 gattaaaaaa aaaaaaaaaa aa
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