LOCUS BC010242 2542 bp mRNA linear HUM 03-OCT-2003
DEFINITION Homo sapiens cystathionine-beta-synthase, mRNA (cDNA clone
MGC:18160 IMAGE:4154798), complete cds.
ACCESSION BC010242
VERSION BC010242.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2542)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2542)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (05-JUL-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: David N. Louis, M.D.
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Baylor College of Medicine Human Genome
Sequencing Center
Center code: BCM-HGSC
Web site: http://www.hgsc.bcm.tmc.edu/cdna/
Contact: amg@bcm.tmc.edu
Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
A.N., Gibbs, R.A.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 19 Row: f Column: 20.
FEATURES Location/Qualifiers
source 1..2542
/db_xref="H-InvDB:HIT000034870"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:18160 IMAGE:4154798"
/tissue_type="Brain, anaplastic oligodendroglioma with
1p/19q loss"
/clone_lib="NCI_CGAP_Brn67"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..2542
/gene="CBS"
/gene_synonym="HIP4"
/db_xref="GeneID:875"
/db_xref="MIM:236200"
CDS 170..1825
/gene="CBS"
/gene_synonym="HIP4"
/codon_start=1
/product="CBS protein"
/protein_id="AAH10242.1"
/db_xref="GeneID:875"
/db_xref="MIM:236200"
/translation="MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWI
RPDAPSRCTWQLGRPASESPHHHTAPAKSPKILPDILKKIGDTPMVRINKIGKKFGLK
CELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAV
RGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSH
ILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCR
IIGVDPEGSILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTF
ARMLIAQEGLLCGGSAGSTVAVAVKAAQELQEGQRCVVILPDSVRNYMTKFLSDRWML
QKGFLKEEDLTEKKPWWWHLRVQELGLSAPLTVLPTITCGHTIEILREKGFDQAPVVD
EAGVILGMVTLGNMLSSLLAGKVQPSDQVGKVIYKQFKQIRLTDTLGRLSHILEMDHF
ALVVHEQIQYHSTGKSSQRQMVFGVVTAIDLLNFVAAQERDQK"
misc_feature 395..1321
/gene="CBS"
/gene_synonym="HIP4"
/note="CysK; Region: Cysteine synthase [Amino acid
transport and metabolism]"
/db_xref="CDD:COG0031"
misc_feature 1433..1576
/gene="CBS"
/gene_synonym="HIP4"
/note="Region: Domain in cystathionine beta-synthase and
other proteins. Domain present in all 3 forms of cellular
life. Present in two copies in inosine monophosphate
dehydrogenase, of which one is disordered in the crystal
structure. A number of disease states are associated with
CBS-containing proteins including homocystinuria, Becker's
and Thomsen disease"
/db_xref="CDD:smart00116"
BASE COUNT 573 a 709 c 774 g 486 t
ORIGIN
1 gcgaggccgc caccccgggg tcgccgtctc cgcctcgccg cagtcggggc agccgctcgc
61 ccctcttttc catgtatccg tccaggatcc catgacagat tctgttgtca cgtctcctta
121 cagagtttga gcggtgctga actgtcagca ccatctgtcc ggtcccagca tgccttctga
181 gaccccccag gcagaagtgg ggcccacagg ctgcccccac cgctcagggc cacactcggc
241 gaaggggagc ctggagaagg ggtccccaga ggataaggaa gccaaggagc ccctgtggat
301 ccggcccgat gctccgagca ggtgcacctg gcagctgggc cggcctgcct ccgagtcccc
361 acatcaccac actgccccgg caaaatctcc aaaaatcttg ccagatattc tgaagaaaat
421 cggggacacc cctatggtca gaatcaacaa gattgggaag aagttcggcc tgaagtgtga
481 gctcttggcc aagtgtgagt tcttcaacgc gggcgggagc gtgaaggacc gcatcagcct
541 gcggatgatt gaggatgctg agcgcgacgg gacgctgaag cccggggaca cgattatcga
601 gccgacatcc gggaacaccg ggatcgggct ggccctggct gcggcagtga ggggctatcg
661 ctgcatcatc gtgatgccag agaagatgag ctccgagaag gtggacgtgc tgcgggcact
721 gggggctgag attgtgagga cgcccaccaa tgccaggttc gactccccgg agtcacacgt
781 gggggtggcc tggcggctga agaacgaaat ccccaattct cacatcctag accagtaccg
841 caacgccagc aaccccctgg ctcactacga caccaccgct gatgagatcc tgcagcagtg
901 tgatgggaag ctggacatgc tggtggcttc agtgggcacg ggcggcacca tcacgggcat
961 tgccaggaag ctgaaggaga agtgtcctgg atgcaggatc attggggtgg atcccgaagg
1021 gtccatcctc gcagagccgg aggagctgaa ccagacggag cagacaacct acgaggtgga
1081 agggatcggc tacgacttca tccccacggt gctggacagg acggtggtgg acaagtggtt
1141 caagagcaac gatgaggagg cgttcacctt tgcccgcatg ctgatcgcgc aagaggggct
1201 gctgtgcggt ggcagtgctg gcagcacggt ggcggtggcc gtgaaggctg cgcaggagct
1261 gcaggagggc cagcgctgcg tggtcattct gcccgactca gtgcggaact acatgaccaa
1321 gttcctgagc gacaggtgga tgctgcagaa gggctttctg aaggaggagg acctcacgga
1381 gaagaagccc tggtggtggc acctccgtgt tcaggagctg ggcctgtcag ccccgctgac
1441 cgtgctcccg accatcacct gtgggcacac catcgagatc ctccgggaga agggcttcga
1501 ccaggcgccc gtggtggatg aggcgggggt aatcctggga atggtgacgc ttgggaacat
1561 gctctcgtcc ctgcttgccg ggaaggtgca gccgtcagac caagttggca aagtcatcta
1621 caagcagttc aaacagatcc gcctcacgga cacgctgggc aggctctcgc acatcctgga
1681 gatggaccac ttcgccctgg tggtgcacga gcagatccag taccacagca ccgggaagtc
1741 cagtcagcgg cagatggtgt tcggggtggt caccgccatt gacttgctga acttcgtggc
1801 cgcccaggag cgggaccaga agtgaagtcc ggagcgctgg gcggtgcgga gcgggcccgc
1861 cacccttgcc cacttctcct tcgctttcct gagccctaaa cacacgcgtg attggtaact
1921 gcctggcctg gcaccgttat ccctgcacac ggcacagagc atccgtctcc cctcgttaac
1981 acatggcttc ctaaatggcc ctgtttacgg cctatgagat gaaatatgtg attttctcta
2041 atgtaacttc ctcttaggat gtttcaccaa ggaaatattg agagagaagt cggccaggta
2101 ggatgaacac aggcaatgac tgcgcagagt ggattaaagg caaaagagag aagagtccag
2161 gaaggggcgg ggagaagcct gggtggctca gcatcctcca cgggctgcgc cgtctgctcg
2221 gggctgagct ggcgggagca gtttgcgtgt ttgggttttt taattgagat gaaattcaaa
2281 taacctaaaa atcaatcact tgaaagtgaa caatcagcgg catttagtac atccagaaag
2341 ttgtgtaggc accacctctg tcacgttccg gaacattctg tcatcaccct gtgaagcaat
2401 catttcccct cccgtcttcc tcctcccctg gcaactgctg atcgactttg tgtctctgtt
2461 gtctaaaata ggttttccct gttctggaca tttcatataa atggaatccc ccaaaaaaaa
2521 aaaaaaaaaa aaaaaaaaaa aa
//