LOCUS BC008962 1205 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens growth differentiation factor 15, mRNA (cDNA clone
MGC:4145 IMAGE:3009858), complete cds.
ACCESSION BC008962
VERSION BC008962.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1205)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1205)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (29-MAY-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Nov 6, 2003 this sequence version replaced BC008962.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Institute for Systems Biology
http://www.systemsbiology.org
contact: amadan@systemsbiology.org
Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha
Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 10 Row: i Column: 12
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 4758935.
FEATURES Location/Qualifiers
source 1..1205
/db_xref="H-InvDB:HIT000034111"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:4145 IMAGE:3009858"
/tissue_type="Muscle, rhabdomyosarcoma"
/clone_lib="NIH_MGC_17"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..1205
/gene="GDF15"
/gene_synonym="GDF-15"
/gene_synonym="MIC-1"
/gene_synonym="MIC1"
/gene_synonym="NAG-1"
/gene_synonym="PDF"
/gene_synonym="PLAB"
/gene_synonym="PTGFB"
/db_xref="GeneID:9518"
/db_xref="HGNC:HGNC:30142"
/db_xref="MIM:605312"
CDS 18..944
/gene="GDF15"
/gene_synonym="GDF-15"
/gene_synonym="MIC-1"
/gene_synonym="MIC1"
/gene_synonym="NAG-1"
/gene_synonym="PDF"
/gene_synonym="PLAB"
/gene_synonym="PTGFB"
/codon_start=1
/product="growth differentiation factor 15"
/protein_id="AAH08962.1"
/db_xref="GeneID:9518"
/db_xref="HGNC:HGNC:30142"
/db_xref="MIM:605312"
/translation="MPGQELRTVNGSQMLLVLLVLSWLPHGGALSLAEASRASFPGPS
ELHSEDSRFRELRKRYEDLLTRLRANQSWEDSNTDLVPAPAVRILTPEVRLGSGGHLH
LRISRAALPEGLPEASRLHRALFRLSPTASRSWDVTRPLRRQLSLARPQAPALHLRLS
PPPSQSDQLLAESSSARPQLELHLRPQAARGRRRARARNGDHCPLGPGRCCRLHTVRA
SLEDLGWADWVLSPREVQVTMCIGACPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVP
ASYNPMVLIQKTDTGVSLQTYDDLLAKDCHCI"
BASE COUNT 231 a 385 c 361 g 228 t
ORIGIN
1 ccgcaacctg cacagccatg cccgggcaag aactcaggac ggtgaatggc tctcagatgc
61 tcctggtgtt gctggtgctc tcgtggctgc cgcatggggg cgccctgtct ctggccgagg
121 cgagccgcgc aagtttcccg ggaccctcag agttgcactc cgaagactcc agattccgag
181 agttgcggaa acgctacgag gacctgctaa ccaggctgcg ggccaaccag agctgggaag
241 attcgaacac cgacctcgtc ccggcccctg cagtccggat actcacgcca gaagtgcggc
301 tgggatccgg cggccacctg cacctgcgta tctctcgggc cgcccttccc gaggggctcc
361 ccgaggcctc ccgccttcac cgggctctgt tccggctgtc cccgacggcg tcaaggtcgt
421 gggacgtgac acgaccgctg cggcgtcagc tcagccttgc aagaccccag gcgcccgcgc
481 tgcacctgcg actgtcgccg ccgccgtcgc agtcggacca actgctggca gaatcttcgt
541 ccgcacggcc ccagctggag ttgcacttgc ggccgcaagc cgccaggggg cgccgcagag
601 cgcgtgcgcg caacggggac cactgtccgc tcgggcccgg gcgttgctgc cgtctgcaca
661 cggtccgcgc gtcgctggaa gacctgggct gggccgattg ggtgctgtcg ccacgggagg
721 tgcaagtgac catgtgcatc ggcgcgtgcc cgagccagtt ccgggcggca aacatgcacg
781 cgcagatcaa gacgagcctg caccgcctga agcccgacac ggtgccagcg ccctgctgcg
841 tgcccgccag ctacaatccc atggtgctca ttcaaaagac cgacaccggg gtgtcgctcc
901 agacctatga tgacttgtta gccaaagact gccactgcat atgagcagtc ctggtccttc
961 cactgtgcac ctgcgcggag gacgcgacct cagttgtcct gccctgtgga atgggctcaa
1021 ggttcctgag acacccgatt cctgcccaaa cagctgtatt tatataagtc tgttatttat
1081 tattaattta ttggggtgac cttcttgggg actcgggggc tggtctgatg gaactgtgta
1141 tttatttaaa actctggtga taaaaataaa gctgtctgaa ctgttaaaaa aaaaaaaaaa
1201 aaaaa
//