LOCUS BC008797 1603 bp mRNA linear HUM 19-MAR-2009
DEFINITION Homo sapiens 3-ketodihydrosphingosine reductase, mRNA (cDNA clone
MGC:3707 IMAGE:3636291), complete cds.
ACCESSION BC008797
VERSION BC008797.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1603)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1603)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (25-MAY-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Aug 19, 2003 this sequence version replaced BC008797.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 12 Row: d Column: 12
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 4503816
The stop codon of the CDS annotated on this record is located > 55
bases upstream of a splice junction, and therefore the mRNA is
predicted to be subject to nonsense-mediated mRNA decay (NMD).
FEATURES Location/Qualifiers
source 1..1603
/db_xref="H-InvDB:HIT000033977"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:3707 IMAGE:3636291"
/tissue_type="Placenta, choriocarcinoma"
/clone_lib="NIH_MGC_21"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..1603
/gene="KDSR"
/gene_synonym="DHSR"
/gene_synonym="SDR35C1"
/db_xref="GeneID:2531"
/db_xref="HGNC:HGNC:4021"
/db_xref="MIM:136440"
CDS 135..1133
/gene="KDSR"
/gene_synonym="DHSR"
/gene_synonym="SDR35C1"
/codon_start=1
/product="KDSR protein"
/protein_id="AAH08797.1"
/db_xref="GeneID:2531"
/db_xref="HGNC:HGNC:4021"
/db_xref="MIM:136440"
/translation="MLLLAAAFLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGI
GKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVSQDYNQVE
NVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAVITTM
KERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITVAYPPD
TDTPGFAEENRTKPLETRLISETTSVCKPEQVAKQIVKDAIQGNFNSSLGSDGYMLSA
LTCGMAPVTSITEGLQQVVTMGLFRTIALFYLGSFDSIVRRCMMQREKSENADKTA"
BASE COUNT 439 a 373 c 385 g 406 t
ORIGIN
1 gccccggccc gcaaacccaa acactccagg cgcccgcccg ccgcgcgtga ttctcgcctc
61 gccgcagccc agccctgcgc gccttgcccg gcggcccccg cccggccgct ccgggcccct
121 ggccccgcgg agcgatgctg ctgctggctg ccgccttcct cgtggccttc gtgctgctgc
181 tgtacatggt gtctccgctc atcagcccca agcccctcgc cctgcccggg gcgcatgtgg
241 tggttacagg aggttccagt ggcatcggga agtgcattgc tatcgagtgc tataaacaag
301 gagcttttat aactctggtt gcacgaaatg aggataagct gctgcaggca aagaaagaaa
361 ttgaaatgca ctctattaat gacaaacagg tggtactttg catatcagtt gatgtatctc
421 aagactataa ccaagtagag aatgtcataa aacaagcaca ggagaaactg ggtccagtgg
481 acatgctggt aaattgtgca ggaatggcag tgtcaggaaa atttgaagat cttgaagtta
541 gtacctttga aaggttaatg agcatcaatt acctgggcag cgtgtacccc agccgggccg
601 tgatcaccac catgaaggag cgccgggtgg gcaggatcgt gtttgtgtcc tcccaggcag
661 gacagttggg attattcggt ttcacagcct actctgcatc caagtttgcc ataaggggat
721 tggcagaagc tttgcagatg gaggtgaagc catataatgt ctacatcaca gttgcttacc
781 caccagacac agacacacct ggctttgccg aagaaaacag aacaaagcct ttggagactc
841 gacttatttc agagaccaca tctgtgtgca aaccagaaca ggtggccaaa caaattgtta
901 aagatgccat acaaggaaat ttcaacagtt cccttggctc agatgggtac atgctctcgg
961 ccctgacctg tgggatggct ccagtaactt ctattactga ggggctccag caggtggtca
1021 ccatgggcct tttccgcact attgctttgt tttaccttgg aagttttgac agcatagttc
1081 gtcgctgcat gatgcagaga gaaaaatctg aaaatgcaga caaaactgcc taatcttctt
1141 accccttgga agaagactgt ttccaaataa tttgaacagc ttgctgctaa atgggaccca
1201 atttttggcc tatagacact tatgtattgt tttcgaatac gtcagattgg accagtgctc
1261 ttcaggaatg tggctgcaag caaggggcta gaagttcacc tcctgacagt attattaata
1321 ctatgcaaat atggaatagg agaccatttg attttctagg ctttgtggta gagaggtgaa
1381 ggtatgagaa ttaatagcgt gtgaacaaag taaagaacag gattccagaa tgatcattaa
1441 atttgtttct atttattctt ttttgccccc ctagagatta agtccagaaa tgtactttct
1501 ggcacataaa gaaatcttga ggactttgtt taaaccttcc ataaaaaaac aattttgctt
1561 atactgctgt aatatttttg taaaaaaaaa aaaaaaaaaa aaa
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