LOCUS BC008761 2518 bp mRNA linear HUM 04-NOV-2003
DEFINITION Homo sapiens latent transforming growth factor beta binding protein
3, mRNA (cDNA clone IMAGE:3349420), partial cds.
ACCESSION BC008761
VERSION BC008761.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2518)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2518)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (25-MAY-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Oct 28, 2003 this sequence version replaced BC008761.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 5 Row: f Column: 12.
FEATURES Location/Qualifiers
source 1..2518
/db_xref="H-InvDB:HIT000087151"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:3349420"
/tissue_type="Colon, adenocarcinoma"
/clone_lib="NIH_MGC_15"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene <1..2518
/gene="LTBP3"
/gene_synonym="DKFZP586M2123"
/gene_synonym="LTBP2"
/db_xref="GeneID:4054"
/db_xref="MIM:602090"
CDS <1..2233
/gene="LTBP3"
/gene_synonym="DKFZP586M2123"
/gene_synonym="LTBP2"
/codon_start=2
/product="LTBP3 protein"
/protein_id="AAH08761.2"
/db_xref="GeneID:4054"
/db_xref="MIM:602090"
/translation="TDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPD
LPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCV
DVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDG
GFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQ
PGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDEC
EAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGS
YRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQH
GCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYS
SAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYC
KQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPE
EMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGS
HCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGG
FQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQ
RRR"
misc_feature 440..544
/gene="LTBP3"
/gene_synonym="DKFZP586M2123"
/gene_synonym="LTBP2"
/note="EGF_CA; Region: Calcium-binding EGF-like domain,
present in a large number of membrane-bound and
extracellular (mostly animal) proteins. Many of these
proteins require calcium for their biological function and
calcium-binding sites have been found to be located at the
N-terminus of particular EGF-like domains"
/db_xref="CDD:cd00054"
misc_feature 569..676
/gene="LTBP3"
/gene_synonym="DKFZP586M2123"
/gene_synonym="LTBP2"
/note="EGF_CA; Region: Calcium-binding EGF-like domain"
/db_xref="CDD:smart00179"
misc_feature 692..784
/gene="LTBP3"
/gene_synonym="DKFZP586M2123"
/gene_synonym="LTBP2"
/note="EGF_CA; Region: Calcium-binding EGF-like domain,
present in a large number of membrane-bound and
extracellular (mostly animal) proteins. Many of these
proteins require calcium for their biological function and
calcium-binding sites have been found to be located at the
N-terminus of particular EGF-like domains"
/db_xref="CDD:cd00054"
misc_feature 815..919
/gene="LTBP3"
/gene_synonym="DKFZP586M2123"
/gene_synonym="LTBP2"
/note="EGF_CA; Region: Calcium-binding EGF-like domain,
present in a large number of membrane-bound and
extracellular (mostly animal) proteins. Many of these
proteins require calcium for their biological function and
calcium-binding sites have been found to be located at the
N-terminus of particular EGF-like domains"
/db_xref="CDD:cd00054"
misc_feature 1247..1372
/gene="LTBP3"
/gene_synonym="DKFZP586M2123"
/gene_synonym="LTBP2"
/note="TB; Region: TB domain. This domain is also known as
the 8 cysteine domain. This family includes the hybrid
domains. This cysteine rich repeat is found in TGF binding
protein and fibrillin"
/db_xref="CDD:pfam00683"
BASE COUNT 461 a 849 c 793 g 415 t
ORIGIN
1 cacggactca ccggtgagtg aggagaggtc agtgcagcag agccacccaa ctgccaccac
61 gactcctgcc cggccctacc ccgagctgat ctcccgtccc tcgcccccga ccatgcgctg
121 gttcctgccg gacttgcctc cttcccgcag cgccgtagag atcgctccca ctcaggtcac
181 agagactgat gagtgccgac tgaaccagaa catctgtggc cacggagagt gcgtgccggg
241 cccccctgac tactcctgcc actgcaaccc cggctaccgg tcacatcccc agcaccgcta
301 ctgcgtggat gtgaacgagt gcgaggcaga gccctgtggc ccggggaggg gcatctgcat
361 gaacaccggc ggctcctaca attgccactg caaccgcggc taccgcctgc acgtgggcgc
421 cggggggcgc tcgtgcgtgg acctgaacga atgcgccaag ccccacctgt gcggcgacgg
481 cggcttctgc atcaactttc ccggtcacta caagtgcaac tgctaccccg gctaccggct
541 caaagcctcc cggcctcctg tgtgcgaaga catcgacgag tgccgggacc caagctcttg
601 cccggatggc aaatgcgaga acaagcccgg gagcttcaag tgcatcgcct gtcagcctgg
661 ctaccgcagc caggggggcg gggcctgtcg cgacgtgaac gagtgcgccg agggcagccc
721 ctgctcgcct ggctggtgcg agaacctccc gggctccttc cgctgcacct gtgcccaggg
781 ctacgcgccc gcgcccgacg gccgcagttg cttggatgtg gacgagtgtg aggctgggga
841 cgtgtgtgac aatggcatct gcagcaacac gccaggatct ttccagtgtc agtgcctctc
901 tggctaccat ctgtccaggg accggagcca ctgcgaggac attgatgagt gtgacttccc
961 tgcagcctgc attgggggtg actgcatcaa taccaatggc tcctacagat gtctttgccc
1021 ccaggggcat cggctggtgg gtggcaggaa atgccaagac atagatgagt gcagccagga
1081 cccgagcctg tgccttcccc atggggcctg caagaacctt cagggctcct atgtgtgtgt
1141 ctgcgatgag ggcttcactc ccacccagga ccagcacggt tgtgaggagg tggagcagcc
1201 ccaccacaag aaggagtgct acctgaactt cgatgacaca gtgttctgcg acagcgtatt
1261 ggccaccaac gtgacccagc aggagtgctg ctgctctctg ggggccggct ggggcgacca
1321 ctgcgaaatc tacccctgcc cagtctacag ctcagccgag ttccacagcc tctgcccaga
1381 cggaaagggc tacacccagg acaacaacat cgtcaactac ggcatcccag cccaccgtga
1441 catcgacgag tgcatgttgt tcgggtcgga gatttgcaag gagggcaagt gcgtgaacac
1501 gcagcctggc tacgagtgct actgcaagca gggcttctac tacgacggga acctgctgga
1561 atgcgtggac gtggacgagt gcctggacga gtccaactgc cggaacggag tgtgtgagaa
1621 cacgcgcggc ggctaccgct gtgcctgcac gccccctgcc gagtacagtc ccgcgcagcg
1681 ccagtgcctg agcccggaag agatggagcg tgccccggag cggcgcgacg tgtgctggag
1741 ccagcgcgga gaggacggca tgtgcgctgg ccccctggcc gggcctgccc tcaccttcga
1801 cgactgctgc tgccgccagg gccgcggctg gggcgcccaa tgccgaccgt gcccgccgcg
1861 cggcgcgggg tcccattgcc cgacatcgca gagcgagagc aattccttct gggacacaag
1921 ccccctgctg ttggggaagc ccccaagaga tgaggacagt tcagaggagg attcagacga
1981 gtgtcgctgc gtgagtggcc gctgcgtgcc gcggccgggc ggcgccgtgt gcgagtgtcc
2041 cggcggcttc cagctcgacg cctcccgcgc ccgctgcgtg gatatcgacg agtgccgaga
2101 gctgaaccag cgcgggctgc tgtgcaagag cgagcgctgc gtgaacacca gcggctcctt
2161 ccgctgcgtc tgcaaagccg gcttcgcgcg cagccgcccg cacggggcct gcgttcccca
2221 gcgccgccgc tgacgccgcc gacgccgccc tcggcccaga cctcggtgat cactgaggga
2281 tttccgcgag ctcggcctca cttctgcccc gacttgtggc tcggacccag ggaccttcag
2341 ggcccgcaga ccctcccggc gccttgagac ccgaggcgcc cctaccggcc cccctccccg
2401 gttagcgggc ggttgtaagg tctccggcgg gcgctgcctg ccttcctccc agagggtgtt
2461 tcctagaaac tgataaatca gatcgtgcct ttttaaaaaa aaaaaaaaaa aaaaaaaa
//