LOCUS BC008145 1448 bp mRNA linear HUM 30-JAN-2008
DEFINITION Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1,
mRNA (cDNA clone MGC:17277 IMAGE:4180383), complete cds.
ACCESSION BC008145
VERSION BC008145.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1448)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1448)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (22-MAY-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: David N. Louis, M.D.
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Baylor College of Medicine Human Genome
Sequencing Center
Center code: BCM-HGSC
Web site: http://www.hgsc.bcm.tmc.edu/cdna/
Contact: amg@bcm.tmc.edu
Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
A.N., Gibbs, R.A.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 12 Row: k Column: 1
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 18375500.
FEATURES Location/Qualifiers
source 1..1448
/db_xref="H-InvDB:HIT000033654"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:17277 IMAGE:4180383"
/tissue_type="Brain, anaplastic oligodendroglioma with
1p/19q loss"
/clone_lib="NCI_CGAP_Brn67"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..1448
/gene="APEX1"
/gene_synonym="APE"
/gene_synonym="APE1"
/gene_synonym="APEN"
/gene_synonym="APX"
/gene_synonym="HAP1"
/gene_synonym="REF-1"
/gene_synonym="REF1"
/db_xref="GeneID:328"
/db_xref="HGNC:HGNC:587"
/db_xref="MIM:107748"
CDS 216..1172
/gene="APEX1"
/gene_synonym="APE"
/gene_synonym="APE1"
/gene_synonym="APEN"
/gene_synonym="APX"
/gene_synonym="HAP1"
/gene_synonym="REF-1"
/gene_synonym="REF1"
/codon_start=1
/product="APEX nuclease (multifunctional DNA repair
enzyme) 1"
/protein_id="AAH08145.1"
/db_xref="GeneID:328"
/db_xref="HGNC:HGNC:587"
/db_xref="MIM:107748"
/translation="MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPAL
YEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSEN
KLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGEEEHDQEGRVIVA
EFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEI
DLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSK
NVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL"
BASE COUNT 399 a 345 c 373 g 331 t
ORIGIN
1 ggagctaggc tgccatcggg ccggtgcaga tacggggttg ctcttttgct cataagaggg
61 gcttcgctgg cagtctgaac ggcaagcttg agtcaggacc cttaattaag atcctcaatt
121 ggctggaggg cagatctcgc gagtagggca acgcggtaaa aatattgctt cggtgggtga
181 cgcggtacag ctgcccaagg gcgttcgtaa cgggaatgcc gaagcgtggg aaaaagggag
241 cggtggcgga agacggggat gagctcagga cagagccaga ggccaagaag agtaagacgg
301 ccgcaaagaa aaatgacaaa gaggcagcag gagagggccc agccctgtat gaggaccccc
361 cagatcagaa aacctcaccc agtggcaaac ctgccacact caagatctgc tcttggaatg
421 tggatgggct tcgagcctgg attaagaaga aaggattaga ttgggtaaag gaagaagccc
481 cagatatact gtgccttcaa gagaccaaat gttcagagaa caaactacca gctgaacttc
541 aggagctgcc tggactctct catcaatact ggtcagctcc ttcggacaag gaagggtaca
601 gtggcgtggg cctgctttcc cgccagtgcc cactcaaagt ttcttacggc ataggcgagg
661 aggagcatga tcaggaaggc cgggtgattg tggctgaatt tgactcgttt gtgctggtaa
721 cagcatatgt acctaatgca ggccgaggtc tggtacgact ggagtaccgg cagcgctggg
781 atgaagcctt tcgcaagttc ctgaagggcc tggcttcccg aaagcccctt gtgctgtgtg
841 gagacctcaa tgtggcacat gaagaaattg accttcgcaa ccccaagggg aacaaaaaga
901 atgctggctt cacgccacaa gagcgccaag gcttcgggga attactgcag gctgtgccac
961 tggctgacag ctttaggcac ctctacccca acacacccta tgcctacacc ttttggactt
1021 atatgatgaa tgctcgatcc aagaatgttg gttggcgcct tgattacttt ttgttgtccc
1081 actctctgtt acctgcattg tgtgacagca agatccgttc caaggccctc ggcagtgatc
1141 actgtcctat caccctatac ctagcactgt gacaccaccc ctaaatcact ttgagcctgg
1201 gaaataagcc ccctcaacca ccattccttc tttaaacact cttcagagaa atctgcattc
1261 tatttctcat gtataaaact aggaatcctc caaccaggct cctgtgatag agttctttta
1321 agcccaagat tttttatttg agggtttttt gttttttaaa aaaaaattga acaaagacta
1381 ctaatgactt tgtttgaatt atccacatga aaataaagag ccatagtttc aaaaaaaaaa
1441 aaaaaaaa
//