LOCUS BC007587 3482 bp mRNA linear HUM 16-SEP-2003
DEFINITION Homo sapiens latrophilin 1, mRNA (cDNA clone IMAGE:3162852),
partial cds.
ACCESSION BC007587
VERSION BC007587.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3482)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3482)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (10-MAY-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Steven Jones, Jennifer Asano, Ian Bosdet, Yaron Butterfield,
Susanna Chan, Readman Chiu, Chris Fjell, Erin Garland, Ran Guin,
Letticia Hsiao, Martin Krzywinski, Reta Kutsche, Oliver Lee, Soo
Sen Lee, Victor Ling, Carrie Mathewson, Candice McLeavy, Steven
Ness, Pawan Pandoh, Anna-Liisa Prabhu, Parvaneh Saeedi, Jacqueline
Schein, Duane Smailus, Michael Smith, Lorraine Spence, Jeff Stott,
Michael Thorne, Miranada Tsai, Natasja van den Bosch, Jill Vardy,
George Yang, Scott Zuyderduyn, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 22 Row: j Column: 17.
FEATURES Location/Qualifiers
source 1..3482
/db_xref="H-InvDB:HIT000086853"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:3162852"
/tissue_type="Brain, neuroblastoma"
/clone_lib="NIH_MGC_19"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene <1..3482
/gene="LPHN1"
/gene_synonym="CIRL1"
/gene_synonym="KIAA0821"
/gene_synonym="LEC2"
/db_xref="GeneID:22859"
CDS <1..2521
/gene="LPHN1"
/gene_synonym="CIRL1"
/gene_synonym="KIAA0821"
/gene_synonym="LEC2"
/codon_start=2
/product="LPHN1 protein"
/protein_id="AAH07587.1"
/db_xref="GeneID:22859"
/translation="WKDMNATEQVHTATMLLDVLEEGAFLLADNVREPARFLAAKENV
VLEVTVLNTEGQVQELVFPQEEYPRKNSIQLSAKTIKQNSRNGVVKVVFILYNNLGLF
LSTENATVKLAGEAGPGGPGGASLVVNSQVIAASINKESSRVFLMDPVIFTVAHLEDK
NHFNANCSFWNYSERSMLGYWSTQGCRLVESNKTHTTCACSHLTNFAVLMAHREIYQG
RINELLLSVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCINLFLAELLFL
VGIDKTQYEIACPIFAGLLHYFFLAAFSWLCLEGVHLYLLLVEVFESEYSRTKYYYLG
GYCFPALVVGIAAAIDYRSYGTEKACWLRVDNYFIWSFIGPVSFVIVVNLVFLMVTLH
KMIRSSSVLKPDSSRLDNIKSWALGAIALLFLLGLTWAFGLLFINKESVVMAYLFTTF
NAFQGVFIFVFHCALQKKVHKEYSKCLRHSYCCIRSPPGGTHGSLKTSAMRSNTRYYT
GTQSRIRRMWNDTVRKQTESSFMAGDINSTPTLNRGTMGNHLLTNPVLQPRGGTSPYN
TLIAESVGFNPSSPPVFNSPGSYREPKHPLGGREACGMDTLPLNGNFNNSYSLRSGDF
PPGDGGPEPPRGRNLADAAAFEKMIISELVHNNLRGSSSAAKGPPPPEPPVPPVPGGG
GEEEAGGPGGADRAEIELLYKALEEPLLLPRAQSVLYQSDLDESESCTAEDGATSRPL
SSPPGRDSLYASGANLRDSPSYPDSSPEGPSEALPPPPPAPPGPPEIYYTSRPPALVA
RNPLQGYYQVRRPSHEGYLAAPGLEGPGPDGDGQMQLVTSL"
misc_feature 488..646
/gene="LPHN1"
/gene_synonym="CIRL1"
/gene_synonym="KIAA0821"
/gene_synonym="LEC2"
/note="GPS; Region: Latrophilin/CL-1-like GPS domain.
Domain present in latrophilin/CL-1, sea urchin REJ and
polycystin"
/db_xref="CDD:pfam01825"
misc_feature 668..1408
/gene="LPHN1"
/gene_synonym="CIRL1"
/gene_synonym="KIAA0821"
/gene_synonym="LEC2"
/note="7tm_2; Region: 7 transmembrane receptor (Secretin
family)"
/db_xref="CDD:pfam00002"
misc_feature 1412..2518
/gene="LPHN1"
/gene_synonym="CIRL1"
/gene_synonym="KIAA0821"
/gene_synonym="LEC2"
/note="Latrophilin; Region: Latrophilin Cytoplasmic
C-terminal region. This family consists of the cytoplasmic
C-terminal region in latrophilin. Latrophilin is a
synaptic Ca2+ independent alpha- latrotoxin (LTX) receptor
and is a novel member of the secretin family of G-protein
coupled receptors that are involved in secretion.
Latrophilin mRNA is present only in neuronal tissue.
Lactrophillin interacts with G-alpha O"
/db_xref="CDD:pfam02354"
BASE COUNT 676 a 1142 c 1005 g 659 t
ORIGIN
1 ctggaaggac atgaatgcca cggagcaggt gcacacggcc accatgctcc tcgacgtcct
61 ggaggagggc gccttcctgc tggccgacaa tgtcagggag cctgcccgct tcctggctgc
121 caaggagaac gtggtcctgg aggtcacagt cctgaacaca gagggccagg tgcaggagct
181 ggtgttcccc caggaggagt acccgagaaa gaactccatc cagctgtctg ccaaaaccat
241 caagcagaac agccgcaatg gggtggtcaa agttgtcttc atcctctaca acaacctggg
301 cctcttcctg tccacggaga atgccacagt gaagctggcc ggcgaagcag gcccgggtgg
361 ccctgggggc gcctctctag tggtgaactc acaggtcatc gcagcatcca tcaacaagga
421 gtccagccgc gtcttcctca tggaccctgt catcttcacc gtggcccacc tggaggacaa
481 gaaccacttc aatgctaact gctccttctg gaactactcg gagcgttcca tgctgggcta
541 ctggtcgacc caaggctgcc gcctggtgga gtccaacaag acccatacca cgtgtgcctg
601 cagccacctc accaacttcg ctgtgctcat ggctcaccgt gagatctacc agggccgcat
661 caacgagctg ctgctgtcgg tcatcacctg ggtgggcatt gtgatctccc tggtctgctt
721 ggccatctgc atctccacct tctgcttcct gcgggggctg cagaccgacc gcaacaccat
781 ccacaagaac ctgtgcatca acctcttcct ggctgagctg ctcttcctgg tcgggatcga
841 caagactcag tatgagattg cctgccccat cttcgccggc ctgctgcact atttcttcct
901 ggctgccttc tcctggctgt gcctggaggg cgtgcacctc tacctgctac tagtggaggt
961 gtttgagagc gagtattccc gcaccaagta ctactacctg ggtggctact gcttcccggc
1021 cctggtggtg ggcatcgcgg ctgccattga ctaccgcagc tacggcaccg agaaggcctg
1081 ctggctccga gtggacaatt acttcatctg gagtttcatc gggccagtct ccttcgttat
1141 cgtggtcaac ctggtgttcc tcatggtgac cctgcacaag atgatccgaa gctcatctgt
1201 gctcaagccc gactccagcc gcctggacaa cattaaatcc tgggcgctgg gggccatcgc
1261 gctgctgttc ctgctgggcc tcacctgggc tttcggcctc ctcttcatca acaaggagtc
1321 ggtggtcatg gcctatctct tcaccacctt caacgccttc cagggggtct tcatcttcgt
1381 ctttcactgc gccttacaga agaaggtgca caaggagtac agcaagtgcc tgcgtcactc
1441 ctactgctgc atccgctccc cacccggggg cactcacgga tccctcaaga cctcagccat
1501 gcgaagcaac acccgctact acacagggac ccagagccga attcggagga tgtggaatga
1561 cactgtgagg aaacagacgg agtcctcctt catggcgggt gacatcaaca gcacccccac
1621 cctgaaccga ggtaccatgg ggaaccacct gctgaccaac cccgtgctgc agccccgtgg
1681 gggcaccagt ccctacaaca ccctcatcgc cgagtcagtg ggcttcaatc cctcctcgcc
1741 ccctgtcttc aactccccag ggagctaccg ggaacccaag caccccttgg gaggccggga
1801 agcctgtggc atggacaccc tgcccctgaa cggcaacttc aataacagtt actccttgcg
1861 aagtggggat ttccctcccg gggatggggg ccctgagccg ccccgaggcc ggaacctagc
1921 cgatgcggcg gcctttgaga agatgatcat ctcagagctg gtgcacaaca acctgcgggg
1981 gagcagcagc gcggccaagg gccctccacc gcctgagccc cctgtgccac ctgtgccagg
2041 gggcgggggc gaggaagagg cgggcgggcc cgggggtgct gaccgggccg agattgaact
2101 tctctataag gccctggagg agcctctgct gctgccccgg gcccagtcgg tgctgtacca
2161 gagcgatctg gacgagtcgg agagctgcac ggccgaggac ggcgccacca gccggcccct
2221 ctcctcccct cctggccggg actccctcta tgccagcggg gccaacctgc gggactcacc
2281 ctcctacccg gacagcagcc ctgaggggcc cagtgaggcc ctgcccccac cccctcccgc
2341 accccccggc ccccccgaaa tctactacac ctcgcgcccg ccagccctgg tggcccggaa
2401 tcccctgcag ggctactacc aggtgcggcg tcctagccac gagggctacc tggcagcccc
2461 aggccttgag gggccagggc ccgatgggga cgggcagatg cagctggtca ccagtctctg
2521 agggcacctc atggaccagg ggctggtggc ccaggccagg gagggaaccc tgggcagggc
2581 tctggtggga gagggagaca gatggaggca gtggctggtg ggccactctc tccaggtgcc
2641 cctcagccat gggccctaca gtcccctcag gggactctaa cctgggggcc tgaggtgcca
2701 gggttcacag acagggtttc ccaccagcca cacgcaccag ctctatttgg gggaagtgta
2761 gtgaggagga gcccagagga ccccagggga gtgaggaggg agaacttgga agggtgcagc
2821 ccacttccag actctcccct ctcccaccct tctaccctgt gaagggaaat gagggcttta
2881 gtttcctggg cagggagggg cagcttctga ggttgccaaa ggcccccact ggatggaacc
2941 tgttagctgc tcctctccgc agccagaaat gctgccggct gcacccagag ggagcagtga
3001 ggcaggacag atggacaggt tcctcctgcg ctgtaattcc ctgctccctg gagactggga
3061 aaaggccgca gggcaggggg actgggcggt ggtggctggt ggtttaaagg ttgaactttc
3121 tctgaagctc ctttcccctt gctcttggtc cctgccccgc aagcaaacct gccccctctg
3181 cctcccagtg cacccaatga ccccctccct tggggcgact cctgatgaag cacaactccc
3241 cgcagggccc ccagcccaca ggggtggcca tatttgggca gttcccagtc ctgtgggctc
3301 ggctatctgg ggagcagatt ttgggtctgg atctccctgg ggagtgggtc ctgggcttgg
3361 atctttccct agggggccct cttactcctt cctctctcct cctccttccc cattgctgta
3421 aatatttcaa cgaaatggaa aagaaaaaaa aaagccaaaa aaaaaaaaaa aaaaaaaaaa
3481 aa
//