LOCUS BC007369 828 bp mRNA linear HUM 11-DEC-2003
DEFINITION Homo sapiens guanylate kinase 1, mRNA (cDNA clone IMAGE:3633616),
partial cds.
ACCESSION BC007369
VERSION BC007369.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 828)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 828)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (01-MAY-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Dec 9, 2003 this sequence version replaced BC007369.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: DCTD/DTP
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Institute for Systems Biology
http://www.systemsbiology.org
contact: amadan@systemsbiology.org
Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha
Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 24 Row: f Column: 11.
FEATURES Location/Qualifiers
source 1..828
/db_xref="H-InvDB:HIT000086805"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:3633616"
/tissue_type="Ovary, adenocarcinoma"
/clone_lib="NIH_MGC_9"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene <1..828
/gene="GUK1"
/gene_synonym="GMK"
/db_xref="GeneID:2987"
/db_xref="MIM:139270"
CDS <1..549
/gene="GUK1"
/gene_synonym="GMK"
/codon_start=1
/product="GUK1 protein"
/protein_id="AAH07369.2"
/db_xref="GeneID:2987"
/db_xref="MIM:139270"
/translation="GKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTRE
VMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRP
IYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLD
QAYAELKEALSEEIKKAQRTGA"
misc_feature 1..519
/gene="GUK1"
/gene_synonym="GMK"
/note="GuKc; Region: Guanylate kinase homologues. Active
members of this family are enzymes which catalyze
ATP-dependent phosphorylation of GMP to GDP. The GuKc
structure resembles that of adenylate kinase.
Membrane-associated guanylate kinase homologs (MAGUKs) do
not possess guanylate kinase activities"
/db_xref="CDD:cd00071"
BASE COUNT 202 a 232 c 253 g 141 t
ORIGIN
1 gggaagagca ccctgctgaa gaggctgctc caggagcaca gcggcatctt tggcttcagc
61 gtgtcccata ccacgaggaa cccgaggccc ggcgaggaga acggcaaaga ttactacttt
121 gtaaccaggg aggtgatgca gcgtgacata gcagccggcg acttcatcga gcatgccgag
181 ttctcgggga acctgtatgg cacgagcaag gtggcggtgc aggccgtgca ggccatgaac
241 cgcatctgtg tgctggacgt ggacctgcag ggtgtgcgga acatcaaggc caccgatctg
301 cggcccatct acatctctgt gcagccgcct tcactgcacg tgctggagca gcggctgcgg
361 cagcgcaaca ctgaaaccga ggagagcctg gtgaagcggc tggctgctgc ccaggccgac
421 atggagagca gcaaggagcc cggcctgttt gatgtggtca tcattaacga cagcctggac
481 caggcctacg cagagctgaa ggaggcgctc tctgaggaaa tcaagaaagc tcaaaggacc
541 ggcgcctgag gcttgctgtc tgttctcggc accccgggcc catacaggac cagggcagca
601 gcattgagcc acccccttgg caggcgatac ggcagctctg tgcccttggc cagcatgtgg
661 agtggaggag atgctgcccc tgtggttgga acatcctggg gtgacccccg acccagcctc
721 gctgggctgt cccctgtccc tatctctcac tctggaccca gggctgacat cctaataaaa
781 taactgttgg attagaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//