LOCUS       BC006850                2530 bp    mRNA    linear   HUM 15-JUL-2006
DEFINITION  Homo sapiens mutL homolog 1, colon cancer, nonpolyposis type 2 (E.
            coli), mRNA (cDNA clone MGC:5172 IMAGE:3451538), complete cds.
ACCESSION   BC006850
VERSION     BC006850.1
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2530)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 2530)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (27-APR-2001) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: ATCC
            cDNA Library Preparation: Life Technologies, Inc.
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: Baylor College of Medicine Human Genome
            Sequencing Center
            Center code: BCM-HGSC
            Web site: http://www.hgsc.bcm.tmc.edu/cdna/
            Contact: amg@bcm.tmc.edu
            Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
            Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
            A.N., Gibbs, R.A.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAK Plate: 3 Row: l Column: 24
            This clone was selected for full length sequencing because it
            passed the following selection criteria: matched mRNA gi: 28559089.
FEATURES             Location/Qualifiers
     source          1..2530
                     /db_xref="H-InvDB:HIT000032957"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:5172 IMAGE:3451538"
                     /tissue_type="Placenta, choriocarcinoma"
                     /clone_lib="NIH_MGC_10"
                     /lab_host="DH10B"
                     /note="Vector: pCMV-SPORT6"
     gene            1..2530
                     /gene="MLH1"
                     /gene_synonym="FCC2"
                     /gene_synonym="hMLH1"
                     /gene_synonym="HNPCC"
                     /gene_synonym="HNPCC2"
                     /gene_synonym="MGC5172"
                     /db_xref="GeneID:4292"
                     /db_xref="HGNC:HGNC:7127"
                     /db_xref="MIM:120436"
     CDS             51..2321
                     /gene="MLH1"
                     /gene_synonym="FCC2"
                     /gene_synonym="hMLH1"
                     /gene_synonym="HNPCC"
                     /gene_synonym="HNPCC2"
                     /gene_synonym="MGC5172"
                     /codon_start=1
                     /product="mutL homolog 1, colon cancer, nonpolyposis type
                     2 (E. coli)"
                     /protein_id="AAH06850.1"
                     /db_xref="GeneID:4292"
                     /db_xref="HGNC:HGNC:7127"
                     /db_xref="MIM:120436"
                     /translation="MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKS
                     TSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGE
                     ALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIA
                     TRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRS
                     IFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAI
                     ETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKL
                     LGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQK
                     LDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGD
                     TTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLS
                     LQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIY
                     DFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLAD
                     YFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAM
                     FYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNI
                     LQLANLPDLYKVFERC"
BASE COUNT          742 a          543 c          601 g          644 t
ORIGIN      
        1 ggcacttccg ttgagcatct agacgtttcc ttggctcttc tggcgccaaa atgtcgttcg
       61 tggcaggggt tattcggcgg ctggacgaga cagtggtgaa ccgcatcgcg gcgggggaag
      121 ttatccagcg gccagctaat gctatcaaag agatgattga gaactgttta gatgcaaaat
      181 ccacaagtat tcaagtgatt gttaaagagg gaggcctgaa gttgattcag atccaagaca
      241 atggcaccgg gatcaggaaa gaagatctgg atattgtatg tgaaaggttc actactagta
      301 aactgcagtc ctttgaggat ttagccagta tttctaccta tggctttcga ggtgaggctt
      361 tggccagcat aagccatgtg gctcatgtta ctattacaac gaaaacagct gatggaaagt
      421 gtgcatacag agcaagttac tcagatggaa aactgaaagc ccctcctaaa ccatgtgctg
      481 gcaatcaagg gacccagatc acggtggagg acctttttta caacatagcc acgaggagaa
      541 aagctttaaa aaatccaagt gaagaatatg ggaaaatttt ggaagttgtt ggcaggtatt
      601 cagtacacaa tgcaggcatt agtttctcag ttaaaaaaca aggagagaca gtagctgatg
      661 ttaggacact acccaatgcc tcaaccgtgg acaatattcg ctccatcttt ggaaatgctg
      721 ttagtcgaga actgatagaa attggatgtg aggataaaac cctagccttc aaaatgaatg
      781 gttacatatc caatgcaaac tactcagtga agaagtgcat cttcttactc ttcatcaacc
      841 atcgtctggt agaatcaact tccttgagaa aagccataga aacagtgtat gcagcctatt
      901 tgcccaaaaa cacacaccca ttcctgtacc tcagtttaga aatcagtccc cagaatgtgg
      961 atgttaatgt gcaccccaca aagcatgaag ttcacttcct gcacgaggag agcatcctgg
     1021 agcgggtgca gcagcacatc gagagcaagc tcctgggctc caattcctcc aggatgtact
     1081 tcacccagac tttgctacca ggacttgctg gcccctctgg ggagatggtt aaatccacaa
     1141 caagtctgac ctcgtcttct acttctggaa gtagtgataa ggtctatgcc caccagatgg
     1201 ttcgtacaga ttcccgggaa cagaagcttg atgcatttct gcagcctctg agcaaacccc
     1261 tgtccagtca gccccaggcc attgtcacag aggataagac agatatttct agtggcaggg
     1321 ctaggcagca agatgaggag atgcttgaac tcccagcccc tgctgaagtg gctgccaaaa
     1381 atcagagctt ggagggggat acaacaaagg ggacttcaga aatgtcagag aagagaggac
     1441 ctacttccag caaccccaga aagagacatc gggaagattc tgatgtggaa atggtggaag
     1501 atgattcccg aaaggaaatg actgcagctt gtaccccccg gagaaggatc attaacctca
     1561 ctagtgtttt gagtctccag gaagaaatta atgagcaggg acatgaggtt ctccgggaga
     1621 tgttgcataa ccactccttc gtgggctgtg tgaatcctca gtgggccttg gcacagcatc
     1681 aaaccaagtt ataccttctc aacaccacca agcttagtga agaactgttc taccagatac
     1741 tcatttatga ttttgccaat tttggtgttc tcaggttatc ggagccagca ccgctctttg
     1801 accttgccat gcttgcctta gatagtccag agagtggctg gacagaggaa gatggtccca
     1861 aagaaggact tgctgaatac attgttgagt ttctgaagaa gaaggctgag atgcttgcag
     1921 actatttctc tttggaaatt gatgaggaag ggaacctgat tggattaccc cttctgattg
     1981 acaactatgt gccccctttg gagggactgc ctatcttcat tcttcgacta gccactgagg
     2041 tgaattggga cgaagaaaag gaatgttttg aaagcctcag taaagaatgc gctatgttct
     2101 attccatccg gaagcagtac atatctgagg agtcgaccct ctcaggccag cagagtgaag
     2161 tgcctggctc cattccaaac tcctggaagt ggactgtgga acacattgtc tataaagcct
     2221 tgcgctcaca cattctgcct cctaaacatt tcacagaaga tggaaatatc ctgcagcttg
     2281 ctaacctgcc tgatctatac aaagtctttg agaggtgtta aatatggtta tttatgcact
     2341 gtgggatgtg ttcttctttc tctgtattcc gatacaaagt gttgtatcaa agtgtgatat
     2401 acaaagtgta ccaacataag tgttggtagc acttaagact tatacttgcc ttctgatagt
     2461 attcctttat acacagtgga ttgattataa ataaatagat gtgtcttaac ataaaaaaaa
     2521 aaaaaaaaaa
//