LOCUS BC006526 3209 bp mRNA linear HUM 06-NOV-2003
DEFINITION Homo sapiens sodium channel, nonvoltage-gated 1 alpha, mRNA (cDNA
clone IMAGE:3936903), partial cds.
ACCESSION BC006526
VERSION BC006526.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3209)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3209)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (24-APR-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Nov 6, 2003 this sequence version replaced BC006526.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: DCTD/DTP
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Institute for Systems Biology
http://www.systemsbiology.org
contact: amadan@systemsbiology.org
Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha
Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 14 Row: n Column: 14
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 4506814.
FEATURES Location/Qualifiers
source 1..3209
/db_xref="H-InvDB:HIT000032899"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:3936903"
/tissue_type="Lung, small cell carcinoma"
/clone_lib="NIH_MGC_7"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene <1..3209
/gene="SCNN1A"
/gene_synonym="ENaCa"
/gene_synonym="ENaCalpha"
/gene_synonym="SCNEA"
/gene_synonym="SCNN1"
/db_xref="GeneID:6337"
/db_xref="MIM:600228"
CDS <1..2137
/gene="SCNN1A"
/gene_synonym="ENaCa"
/gene_synonym="ENaCalpha"
/gene_synonym="SCNEA"
/gene_synonym="SCNN1"
/codon_start=2
/product="SCNN1A protein"
/protein_id="AAH06526.2"
/db_xref="GeneID:6337"
/db_xref="MIM:600228"
/translation="GTQGPELSLDPDPCSPQSTPGLMKGNKLEEQDPRPLQPIPGLME
GNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFE
FFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNI
NLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRS
RRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKS
DCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQA
NYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGAR
VMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYP
SKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSS
DHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKV
NIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFL
MLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAP
PPAYATLGPRPSPGGSAGASSSTCPLGGP"
misc_feature 311..625
/gene="SCNN1A"
/gene_synonym="ENaCa"
/gene_synonym="ENaCalpha"
/gene_synonym="SCNEA"
/gene_synonym="SCNN1"
/note="ASC; Region: Amiloride-sensitive sodium channel"
/db_xref="CDD:pfam00858"
misc_feature 827..1840
/gene="SCNN1A"
/gene_synonym="ENaCa"
/gene_synonym="ENaCalpha"
/gene_synonym="SCNEA"
/gene_synonym="SCNN1"
/note="ASC; Region: Amiloride-sensitive sodium channel"
/db_xref="CDD:pfam00858"
BASE COUNT 714 a 1004 c 806 g 685 t
ORIGIN
1 gggcactcag ggcccagagc tcagccttga ccctgaccct tgctctcccc aatccactcc
61 ggggctcatg aaggggaaca agctggagga gcaggaccct agacctctgc agcccatacc
121 aggtctcatg gaggggaaca agctggagga gcaggactct agccctccac agtccactcc
181 agggctcatg aaggggaaca agcgtgagga gcaggggctg ggccccgaac ctgcggcgcc
241 ccagcagccc acggcggagg aggaggccct gatcgagttc caccgctcct accgagagct
301 cttcgagttc ttctgcaaca acaccaccat ccacggcgcc atccgcctgg tgtgctccca
361 gcacaaccgc atgaagacgg ccttctgggc agtgctgtgg ctctgcacct ttggcatgat
421 gtactggcaa ttcggcctgc ttttcggaga gtacttcagc taccccgtca gcctcaacat
481 caacctcaac tcggacaagc tcgtcttccc cgcagtgacc atctgcaccc tcaatcccta
541 caggtacccg gaaattaaag aggagctgga ggagctggac cgcatcacag agcagacgct
601 ctttgacctg tacaaataca gctccttcac cactctcgtg gccggctccc gcagccgtcg
661 cgacctgcgg gggactctgc cgcacccctt gcagcgcctg agggtcccgc ccccgcctca
721 cggggcccgt cgagcccgta gcgtggcctc cagcttgcgg gacaacaacc cccaggtgga
781 ctggaaggac tggaagatcg gcttccagct gtgcaaccag aacaaatcgg actgcttcta
841 ccagacatac tcatcagggg tggatgcggt gagggagtgg taccgcttcc actacatcaa
901 catcctgtcg aggctgccag agactctgcc atccctggag gaggacacgc tgggcaactt
961 catcttcgcc tgccgcttca accaggtctc ctgcaaccag gcgaattact ctcacttcca
1021 ccacccgatg tatggaaact gctatacttt caatgacaag aacaactcca acctctggat
1081 gtcttccatg cctggaatca acaacggtct gtccctgatg ctgcgcgcag agcagaatga
1141 cttcattccc ctgctgtcca cagtgactgg ggcccgggta atggtgcacg ggcaggatga
1201 acctgccttt atggatgatg gtggctttaa cttgcggcct ggcgtggaga cctccatcag
1261 catgaggaag gaaaccctgg acagacttgg gggcgattat ggcgactgca ccaagaatgg
1321 cagtgatgtt cctgttgaga acctttaccc ttcaaagtac acacagcagg tgtgtattca
1381 ctcctgcttc caggagagca tgatcaagga gtgtggctgt gcctacatct tctatccgcg
1441 gccccagaac gtggagtact gtgactacag aaagcacagt tcctgggggt actgctacta
1501 taagctccag gttgacttct cctcagacca cctgggctgt ttcaccaagt gccggaagcc
1561 atgcagcgtg accagctacc agctctctgc tggttactca cgatggccct cggtgacatc
1621 ccaggaatgg gtcttccaga tgctatcgcg acagaacaat tacaccgtca acaacaagag
1681 aaatggagtg gccaaagtca acatcttctt caaggagctg aactacaaaa ccaattctga
1741 gtctccctct gtcacgatgg tcaccctcct gtccaacctg ggcagccagt ggagcctgtg
1801 gttcggctcc tcggtgttgt ctgtggtgga gatggctgag ctcgtctttg acctgctggt
1861 catcatgttc ctcatgctgc tccgaaggtt ccgaagccga tactggtctc caggccgagg
1921 gggcaggggt gctcaggagg tagcctccac cctggcatcc tcccctcctt cccacttctg
1981 cccccacccc atgtctctgt ccttgtccca gccaggccct gctccctctc cagccttgac
2041 agcccctccc cctgcctatg ccaccctggg cccccgccca tctccagggg gctctgcagg
2101 ggccagttcc tccacctgtc ctctgggggg gccctgagag ggaaggagag gtttctcaca
2161 ccaaggcaga tgctcctctg gtgggagggt gctggccctg gcaagattga aggatgtgca
2221 gggcttcctc tcagagccgc ccaaactgcc gttgatgtgt ggaggggaag caagatgggt
2281 aagggctcag gaagttgctc caagaacagt agctgatgaa gctgcccaga agtgccttgg
2341 ctccagccct gtaccccttg gtactgcctc tgaacactct ggtttcccca cccaactgcg
2401 gctaagtctc tttttccctt ggatcagcca agcgaaactt ggagctttga caaggaactt
2461 tcctaagaaa ccgctgataa ccaggacaaa acacaaccaa gggtacacgc aggcatgcac
2521 gggtttcctg cccagcgacg gcttaagcca gcccccgact ggcctggcca cactgctctc
2581 cagtagcaca gatgtctgct cctcctcttg aacttgggtg ggaaacccca cccaaaagcc
2641 ccctttgtta cttaggcaat tccccttccc tgactcccga gggctagggc tagagcagac
2701 ccgggtaagt aaaggcagac ccagggctcc tctagcctca tacccgtgcc ctcacagagc
2761 catgccccgg cacctctgcc ctgtgtcttt catacctcta catgtctgct tgagatattt
2821 cctcagcctg aaagtttccc caaccatctg ccagagaact cctatgcatc ccttagaacc
2881 ctgctcagac accattactt ttgtgaacgc ttctgccaca tcttgtcttc cccaaaattg
2941 atcactccgc cttctcctgg gctcccgtag cacactataa catctgctgg agtgttgctg
3001 ttgcaccata ctttcttgta catttgtgtc tcccttccca actagactgt aagtgccttg
3061 cggtcaggga ctgaatcttg cccgtttatg tatgctccat gtctagccca tcatcctgct
3121 tggagcaagt aggcaggagc tcaataaatg tttgttgcat gaagaaaaaa aaaaaaaaaa
3181 aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//