LOCUS BC006498 3073 bp mRNA linear HUM 09-JUN-2008
DEFINITION Homo sapiens ribonucleotide reductase M1, mRNA (cDNA clone MGC:2326
IMAGE:2989344), complete cds.
ACCESSION BC006498
VERSION BC006498.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3073)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3073)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (17-APR-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Aug 19, 2003 this sequence version replaced BC006498.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Louis M. Staudt, M.D., Ph.D.
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Institute for Systems Biology
http://www.systemsbiology.org
contact: amadan@systemsbiology.org
Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha
Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 3 Row: c Column: 10
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 21071083.
FEATURES Location/Qualifiers
source 1..3073
/db_xref="H-InvDB:HIT000032878"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:2326 IMAGE:2989344"
/tissue_type="Lymph, Burkitt lymphoma"
/clone_lib="NIH_MGC_8"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..3073
/gene="RRM1"
/gene_synonym="R1"
/gene_synonym="RIR1"
/gene_synonym="RR1"
/db_xref="GeneID:6240"
/db_xref="HGNC:HGNC:10451"
/db_xref="MIM:180410"
CDS 160..2538
/gene="RRM1"
/gene_synonym="R1"
/gene_synonym="RIR1"
/gene_synonym="RR1"
/codon_start=1
/product="ribonucleotide reductase M1"
/protein_id="AAH06498.1"
/db_xref="GeneID:6240"
/db_xref="HGNC:HGNC:10451"
/db_xref="MIM:180410"
/translation="MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVI
QGLYSGVTTVELDTLAAETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLY
NYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKIN
GKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSC
FLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPML
RVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWI
PDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYA
IIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLA
LNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGL
ADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGIL
QYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNI
YTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKT
VWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLR
TRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCSLENRDECLMCGS"
BASE COUNT 954 a 598 c 692 g 829 t
ORIGIN
1 ctgctctgaa gaaagtgctg tctggctcca actccagttc tttcccctga gcagcgcctg
61 gaacctaacc cttcccactc tgtcaccttc tcgatcccgc cggcgcttta gagccgcagt
121 ccagtcttgg atccttcaga gcctcagcca ctagctgcga tgcatgtgat caagcgagat
181 ggccgccaag aacgagtcat gtttgacaaa attacatctc gaatccagaa gctttgttat
241 ggactcaata tggattttgt tgatcctgct cagatcacca tgaaagtaat ccaaggcttg
301 tacagtgggg tcaccacagt ggaactagat actttggctg ctgaaacagc tgcaaccttg
361 actactaagc accctgacta tgctatcctg gcagccagga tcgctgtctc taacttgcac
421 aaagaaacaa agaaagtgtt cagtgatgtg atggaagacc tctataacta cataaatcca
481 cataatggca aacactctcc catggtggcc aagtcaacat tggatattgt tctggccaat
541 aaagatcgcc tgaattctgc tattatctat gaccgagatt tctcttacaa ttacttcggc
601 tttaagacgc tagagcggtc ttatttgttg aagatcaatg gaaaagtggc tgaaagacca
661 caacatatgt tgatgagagt atctgttggg atccacaaag aagacattga tgcagcaatt
721 gaaacatata atcttctttc tgagaggtgg tttactcatg cttcgcccac tctcttcaat
781 gctggtacca accgcccaca actttctagc tgttttcttc tgagtatgaa agatgacagc
841 attgaaggca tttatgacac tctaaagcaa tgtgcattga tttctaagtc tgctggagga
901 attggtgttg ctgtgagttg tattcgggct actggcagct acattgctgg gactaatggc
961 aattccaatg gccttgtacc gatgctgaga gtatataaca acacagctag atatgtggat
1021 caaggtggga acaagcgtcc tggggcattt gctatttacc tggagccttg gcatttagac
1081 atctttgaat tccttgattt aaagaagaac acaggaaagg aagagcagcg tgccagagat
1141 cttttctttg ctctttggat tccggatctc ttcatgaaac gagtggagac taatcaggac
1201 tggtctttga tgtgtccaaa tgagtgtcct ggtctggatg aggtttgggg agaggaattt
1261 gagaaactat atgcaagtta tgagaaacaa ggtcgtgtcc gcaaagttgt aaaagctcag
1321 cagctttggt atgccatcat tgagtctcag acggaaacag gcaccccgta tatgctctac
1381 aaagattcct gtaatcgaaa gagcaaccag cagaacctgg gaaccatcaa atgcagcaac
1441 ctgtgcacag aaatagtgga gtacaccagc aaagatgagg ttgctgtttg taatttggct
1501 tccctggccc tgaatatgta tgtcacatca gaacacacat acgactttaa gaagttggct
1561 gaagtcacta aagtcgttgt ccgaaacttg aataaaatta ttgatataaa ctactatcct
1621 gtaccagagg catgcctatc aaataaacgc catcgcccca ttggaattgg ggtacaaggt
1681 ctggcagatg cttttatcct gatgagatac ccttttgaga gtgcagaagc ccagttactg
1741 aataagcaga tctttgaaac tatttattat ggtgctctgg aagccagctg tgaccttgcc
1801 aaggagcagg gcccatacga aacctatgag ggctctccag ttagcaaagg aattcttcag
1861 tatgatatgt ggaatgttac tcctacagac ctatgggact ggaaggttct caaggagaag
1921 attgcaaagt atggtataag aaacagttta cttattgccc cgatgcctac agcttccact
1981 gctcagatcc tggggaataa tgagtccatt gaaccttaca ccagcaacat ctatactcgc
2041 agagtcttgt caggagaatt tcagattgta aatcctcact tattgaaaga tcttaccgag
2101 cggggcctat ggcatgaaga gatgaaaaac cagattattg catgcaatgg ctctattcag
2161 agcataccag aaattcctga tgacctgaag caactttata aaactgtgtg ggaaatctct
2221 cagaaaactg ttctcaagat ggcagctgag agaggtgctt tcattgatca aagccaatct
2281 ttgaacatcc acattgctga gcctaactat ggcaaactca ctagtatgca cttctacggc
2341 tggaagcagg gtttgaagac tgggatgtat tatttaagga cgagaccagc agctaatcca
2401 atccagttca ctctaaataa ggagaagcta aaagataaag aaaaggtatc aaaagaggaa
2461 gaagagaagg agaggaacac agcagccatg gtgtgctctt tggagaatag agatgaatgt
2521 ctgatgtgtg gatcctgagg aaagacttgg aagagaccag catgtcttca gtagccaaac
2581 tacttcttga gcatagatag gtatagtggg tttgcttgag gtggtaaggc tttgctggac
2641 cctgttgcag gcaaaaggag taattgattt aaagtactgt taatgatgtt aatgattttt
2701 ttttaaactc atatattggg attttcacca aaataatgct tttgaaaaaa agaaaaaaaa
2761 aacggatata ttgagaatca aagtagaagt tttaggaatg caaaataagt catcttgcat
2821 acagggagtg gttaagtaag gtttcatcac ccatttagca ctgcttttct gaagacttca
2881 gttttgttaa ggagatttag ttttactgct ttgactggtg ggtctctaga agcaaaactg
2941 agtgataact catgagaagt actgatagga cctttatctg gatatggtcc tataggttat
3001 tctgaaataa agataaacat ttctaagtga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
3061 aaaaaaaaaa aaa
//