LOCUS BC006158 2672 bp mRNA linear HUM 16-SEP-2003
DEFINITION Homo sapiens chloride channel 7, mRNA (cDNA clone IMAGE:3628560),
partial cds.
ACCESSION BC006158
VERSION BC006158.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2672)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2672)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (02-APR-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Steven Jones, Jennifer Asano, Ian Bosdet, Yaron Butterfield,
Susanna Chan, Readman Chiu, Chris Fjell, Erin Garland, Ran Guin,
Letticia Hsiao, Martin Krzywinski, Reta Kutsche, Oliver Lee, Soo
Sen Lee, Victor Ling, Carrie Mathewson, Candice McLeavy, Steven
Ness, Pawan Pandoh, Anna-Liisa Prabhu, Parvaneh Saeedi, Jacqueline
Schein, Duane Smailus, Michael Smith, Lorraine Spence, Jeff Stott,
Michael Thorne, Miranada Tsai, Natasja van den Bosch, Jill Vardy,
George Yang, Scott Zuyderduyn, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 18 Row: h Column: 1.
FEATURES Location/Qualifiers
source 1..2672
/db_xref="H-InvDB:HIT000086604"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:3628560"
/tissue_type="Brain, neuroblastoma"
/clone_lib="NIH_MGC_19"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene <1..2672
/gene="CLCN7"
/gene_synonym="CLC-7"
/gene_synonym="CLC7"
/gene_synonym="OPTA2"
/db_xref="GeneID:1186"
/db_xref="MIM:602727"
CDS <1..1363
/gene="CLCN7"
/gene_synonym="CLC-7"
/gene_synonym="CLC7"
/gene_synonym="OPTA2"
/codon_start=2
/product="CLCN7 protein"
/protein_id="AAH06158.1"
/db_xref="GeneID:1186"
/db_xref="MIM:602727"
/translation="SSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALN
YWLTMFRIRYIHRPCLQVIEAMLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFC
ADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAG
VFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIM
MEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAR
EVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIV
LLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPS
PYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRLGKRGLEELSL
AQT"
misc_feature 8..739
/gene="CLCN7"
/gene_synonym="CLC-7"
/gene_synonym="CLC7"
/gene_synonym="OPTA2"
/note="voltage_CLC; Region: Voltage gated chloride
channel. This family of ion channels contains 10 or 12
transmembrane helices. Each protein forms a single pore.
It has been shown that some members of this family form
homodimers. These proteins contain two pfam00571 domains"
/db_xref="CDD:pfam00654"
misc_feature 1160..1315
/gene="CLCN7"
/gene_synonym="CLC-7"
/gene_synonym="CLC7"
/gene_synonym="OPTA2"
/note="CBS; Region: CBS domain. CBS domains are small
intracellular modules of unknown function. They are mostly
found in 2 or four copies within a protein. Pairs of CBS
domains dimerise to form a stable globular domain. Two CBS
domains are found in inosine-monophosphate dehydrogenase
from all species, however the CBS domains are not needed
for activity. CBS domains are found attached to a wide
range of other protein domains suggesting that CBS domains
may play a regulatory role. The region containing the CBS
domains in Cystathionine-beta synthase is involved in
regulation by S-AdoMet"
/db_xref="CDD:pfam00571"
BASE COUNT 445 a 910 c 818 g 499 t
ORIGIN
1 gtccagccca ggcctcatca acttcggaag gtttgactcg gagaaaatgg cctacacgat
61 ccacgagatc ccagtcttca tcgccatggg cgtggtgggc ggtgtgcttg gagctgtgtt
121 caatgccttg aactactggc tgaccatgtt tcgaatcagg tacatccacc ggccctgcct
181 gcaggtgatc gaggccatgc tggtggccgc cgtcacggcc acagttgcct tcgtgctgat
241 ctactcgtcg cgggattgcc agcccctgca ggggggctcc atgtcctacc cgctgcagct
301 cttttgtgca gatggcgagt acaactccat ggctgcggcc ttcttcaaca ccccggagaa
361 gagcgtggtg agcctcttcc acgacccgcc aggctcctac aaccccctga ccctcggcct
421 gttcacgctg gtctacttct tcctggcctg ctggacctac gggctcacgg tgtctgccgg
481 ggtcttcatc ccgtccctgc tcatcggggc tgcctggggc cggctctttg ggatctccct
541 gtcctacctc acgggggcag cgatctgggc ggaccccggc aaatacgccc tgatgggagc
601 tgctgcccag ctgggcggga ttgtgcggat gacactgagc ctgaccgtca tcatgatgga
661 ggccaccagc aacgtgacct acggcttccc catcatgctg gtgctcatga ccgccaagat
721 cgtgggcgac gtcttcattg agggcctgta cgacatgcac attcagctgc agagtgtgcc
781 cttcctgcac tgggaggccc cggtcacctc acactcactc actgccaggg aggtgatgag
841 cacaccagtg acctgcctga ggcggcgtga gaaggtcggc gtcattgtgg acgtgctgag
901 cgacacggcg tccaatcaca acggcttccc cgtggtggag catgccgatg acacccagcc
961 tgcccggctc cagggcctga tcctgcgctc ccagctcatc gttctcctaa agcacaaggt
1021 gtttgtggag cggtccaacc tgggcctggt acagcggcgc ctgaggctga aggacttccg
1081 agacgcctac ccgcgcttcc cacccatcca gtccatccac gtgtcccagg acgagcggga
1141 gtgcaccatg gacctctccg agttcatgaa cccctccccc tacacggtgc cccaggaggc
1201 gtcgctccca cgggtgttca agctgttccg ggccctgggc ctgcggcacc tggtggtggt
1261 ggacaaccgc aatcaggttg tcgggttggt gaccaggaag gacctcgcca ggtaccgcct
1321 gggaaagaga ggcttggagg agctctcgct ggcccagacg tgaggcccag ccctgcccat
1381 agtgggcact ggcgctggca ccccggccct tctgcatttc ctcccggagt cactggtttc
1441 tcggcccaaa ccatgctccc cagcagtggc aatggcgagc accctgcagc tgggcgggca
1501 ggcggcaggc gcggaactga ccctctcgcg ggactgaccc tgttgtgggc agtggtctcc
1561 ccccttggcg cctccttgcg caggcccagc ctccactctc ctcgtctagg tttctttacc
1621 tccagggatc agctgtgtgt gtgtgacctc cctaccgggc tatcggcctc ttgggagcca
1681 gcggcagggc cggcacctgc gtgcctgtgc ccgtgtgcgt gagacagagc ccttgcccct
1741 gctgctgccc cgagggctgc cctgccctgg aagggcccct ctgcctccac accagtggag
1801 tcttcgagac ttgggagctg cttggcctca ttttcagcca tgagcagacg gcctgtggtc
1861 cctgggcctg aggcacggac tcgtagcacc agggtttgga ggctgcgacc gccccggaga
1921 gcagcttcac actggcgcca cagaggagcc ccacgtgcac tccccggcct gcatccggct
1981 tgggtacacg ggcccagagg actggggtga ctcacgggcc ctgtgctgtg atgttgagag
2041 ctgagaaaaa cctccaaggc cctgagcccc atgcccagcc ctgccttggt cccccaaccc
2101 ccagagcttg gagtctgggc cccacaccca gccctgcctt ggtccctgag cctcagagcg
2161 tggaattgct gccctgtgga cactggctgg gaaggcaggt cttcccctag cacatgggga
2221 ccccggcctc gagggtgacc tccctacccc gcccctgcca gccaccaagc gcaggtgcag
2281 cgggggccag actcctgccg gcctcagagg acacctggcc cagcacaggc agctagaagg
2341 gccggtgggc accggggccg ggaagccccc acctcaccac ctgagggccc ctgggaggct
2401 cctctggcct ggctgggctg ggtctggggc cgccacaggc ccctcacggg gcggcagagg
2461 caacttcagt gtccctgtta gagcaacacg ggtccctccg tggggggctg ggtgcggccc
2521 cctgccgtgt atttcctccc cagggagtgg ggcctccccg ggagctgacg ccaccaccct
2581 gcttagccct cacagggccc caaggtgtcc gagtgtgttg ggtctgaacg cgaaataaag
2641 aaatcctctc aaaaaaaaaa aaaaaaaaaa aa
//