LOCUS BC005858 1403 bp mRNA linear HUM 05-NOV-2003
DEFINITION Homo sapiens fibronectin 1, mRNA (cDNA clone IMAGE:3506187),
partial cds.
ACCESSION BC005858
VERSION BC005858.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1403)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1403)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (02-APR-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Oct 28, 2003 this sequence version replaced BC005858.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: DCTD/DTP
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Institute for Systems Biology
http://www.systemsbiology.org
contact: amadan@systemsbiology.org
Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha
Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 7 Row: n Column: 23.
FEATURES Location/Qualifiers
source 1..1403
/db_xref="H-InvDB:HIT000032481"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:3506187"
/tissue_type="Kidney, renal cell adenocarcinoma"
/clone_lib="NIH_MGC_14"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene <1..1403
/gene="FN1"
/gene_synonym="CIG"
/gene_synonym="FINC"
/gene_synonym="FN"
/gene_synonym="LETS"
/db_xref="GeneID:2335"
/db_xref="MIM:135600"
CDS <1..637
/gene="FN1"
/gene_synonym="CIG"
/gene_synonym="FINC"
/gene_synonym="FN"
/gene_synonym="LETS"
/codon_start=2
/product="FN1 protein"
/protein_id="AAH05858.2"
/db_xref="GeneID:2335"
/db_xref="MIM:135600"
/translation="KDQQRHKVREEVVTVGNSVNEGLNQPTDDSCFDPYTVSHYAVGD
EWERMSESGFKLLCQCLGFGSGHFRCDSSRWCHDNGVNYKIGEKWDRQGENGQMMSCT
CLGNGKGEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNCRR
PGGEPSPEGTTGQSYNQYSQRYHQRTNTNVNCPIECFMPLDVQADREDSRE"
misc_feature 92..226
/gene="FN1"
/gene_synonym="CIG"
/gene_synonym="FINC"
/gene_synonym="FN"
/gene_synonym="LETS"
/note="Region: Fibronectin type 1 domain"
/db_xref="CDD:smart00058"
misc_feature 227..352
/gene="FN1"
/gene_synonym="CIG"
/gene_synonym="FINC"
/gene_synonym="FN"
/gene_synonym="LETS"
/note="Region: Fibronectin type 1 domain"
/db_xref="CDD:smart00058"
misc_feature 356..475
/gene="FN1"
/gene_synonym="CIG"
/gene_synonym="FINC"
/gene_synonym="FN"
/gene_synonym="LETS"
/note="Region: Fibronectin type 1 domain, approximately 40
residue long with two conserved disulfide bridges. FN1 is
one of three types of internal repeats which combine to
form larger domains within fibronectin. Fibronectin, a
plasma protein that binds cell surfaces and various
compounds including collagen, fibrin, heparin, DNA, and
actin, usually exists as a dimer in plasma and as an
insoluble multimer in extracellular matrices. Dimers of
nearly identical subunits are linked by a disulfide bond
close to their C-terminus. FN1 domains also found in
coagulation factor XII, HGF activator, and tissue-type
plasminogen activator. In tissue plasminogen activator,
FN1 domains may form functional fibrin-binding units with
EGF-like domains C-terminal to FN1"
/db_xref="CDD:cd00061"
BASE COUNT 455 a 268 c 304 g 376 t
ORIGIN
1 gaaagaccag cagaggcata aggttcggga agaggttgtt accgtgggca actctgtcaa
61 cgaaggcttg aaccaaccta cggatgactc gtgctttgac ccctacacag tttcccatta
121 tgccgttgga gatgagtggg aacgaatgtc tgaatcaggc tttaaactgt tgtgccagtg
181 cttaggcttt ggaagtggtc atttcagatg tgattcatct agatggtgcc atgacaatgg
241 tgtgaactac aagattggag agaagtggga ccgtcaggga gaaaatggcc agatgatgag
301 ctgcacatgt cttgggaacg gaaaaggaga attcaagtgt gaccctcatg aggcaacgtg
361 ttatgatgat gggaagacat accacgtagg agaacagtgg cagaaggaat atctcggtgc
421 catttgctcc tgcacatgct ttggaggcca gcggggctgg cgctgtgaca actgccgcag
481 acctgggggt gaacccagtc ccgaaggcac tactggccag tcctacaacc agtattctca
541 gagataccat cagagaacaa acactaatgt taattgccca attgagtgct tcatgccttt
601 agatgtacag gctgacagag aagattcccg agagtaaatc atctttccaa tccagaggaa
661 caagcatgtc tctctgccaa gatccatcta aactggagtg atgttagcag acccagctta
721 gagttcttct ttctttctta agccctttgc tctggaggaa gttctccagc ttcagctcaa
781 ctcacagctt ctccaagcat caccctggga gtttcctgag ggttttctca taaatgaggg
841 ctgcacattg cctgttctgc ttcgaagtat tcaataccgc tcagtatttt aaatgaagtg
901 attctaagat ttggtttggg atcaatagga aagcatatgc agccaaccaa gatgcaaatg
961 ttttgaaatg atatgaccaa aattttaagt aggaaagtca cccaaacact tctgctttca
1021 cttaagtgtc tggcccgcaa tactgtagga acaagcatga tcttgttact gtgatatttt
1081 aaatatccac agtactcact ttttccaaat gatcctagta attgcctaga aatatctttc
1141 tcttacctgt tatttatcaa tttttcccag tatttttata cggaaaaaat tgtattgaaa
1201 acacttagta tgcagttgat aagaggaatt tggtataatt atggtgggtg attatttttt
1261 atactgtatg tgccaaagct ttactactgt ggaaagacaa ctgttttaat aaaagattta
1321 cattccacaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
1381 aaaaaaaaaa aaaaaaaaaa aaa
//