LOCUS BC005855 1603 bp mRNA linear HUM 30-MAR-2004
DEFINITION Homo sapiens leucine zipper, putative tumor suppressor 2, mRNA
(cDNA clone IMAGE:2988487), partial cds.
ACCESSION BC005855
VERSION BC005855.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1603)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1603)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (02-APR-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Oct 28, 2003 this sequence version replaced BC005855.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Institute for Systems Biology
http://www.systemsbiology.org
contact: amadan@systemsbiology.org
Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha
Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 3 Row: n Column: 17
This clone was selected for full length sequencing because it
passed the following selection criteria: Hexamer frequency ORF
analysis.
FEATURES Location/Qualifiers
source 1..1603
/db_xref="H-InvDB:HIT000086542"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:2988487"
/tissue_type="Colon, adenocarcinoma"
/clone_lib="NIH_MGC_15"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene <1..1603
/gene="LZTS2"
/gene_synonym="KIAA1813"
/gene_synonym="LAPSER1"
/db_xref="GeneID:84445"
CDS <1..925
/gene="LZTS2"
/gene_synonym="KIAA1813"
/gene_synonym="LAPSER1"
/codon_start=2
/product="LZTS2 protein"
/protein_id="AAH05855.2"
/db_xref="GeneID:84445"
/translation="RHWQREREALREDCAAQAQRAQRAQQLLQLQVFQLQQEKRQLQD
DFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQLKESQAEL
VQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEACSQELQRHRQEAEQ
LREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQVERLRV
ELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQL
SLELEARELADLGLAEQAPCICLEEITATEI"
misc_feature 230..790
/gene="LZTS2"
/gene_synonym="KIAA1813"
/gene_synonym="LAPSER1"
/note="Fez1; Region: Fez1. This family represents the
eukaryotic Fez1 protein. Fez1 contains a leucine-zipper
region with similarity to the DNA-binding domain of the
cAMP-responsive activating-transcription factor 5. There
is evidence that Fez1 inhibits cancer cell growth through
regulation of mitosis, and that its alterations result in
abnormal cell growth. Note that some family members
contain more than one copy of this region"
/db_xref="CDD:pfam06818"
BASE COUNT 346 a 456 c 534 g 267 t
ORIGIN
1 gcggcactgg cagcgagagc gtgaggccct gcgagaggac tgtgcggccc aggcacagcg
61 ggcacagcgg gcccaacagc tgctgcagct gcaggtgttc cagctgcagc aggagaagcg
121 gcaattgcag gacgacttcg cacagctgct gcaggagcgc gaacagctgg agcggcgctg
181 cgccaccttg gagcgggagc agcgggagct cgggccgagg cttgaggaga ccaagtggga
241 ggtgtgccag aaatcaggcg agatctccct gctgaagcag cagctgaaag agtctcaggc
301 agagctggtg cagaagggca gcgagctggt ggctctgcgg gtggcgctgc gggaggcccg
361 tgctacgctg cgggtcagtg agggccgtgc gcggggtcta caggaggccg cccgagctcg
421 ggagctggag ctggaagcct gttcccagga gctgcagcga caccgccagg aagctgagca
481 gctgcgggag aaagctgggc agttggatgc tgaggcggcc ggactccggg agccccctgt
541 gccacctgcc accgctgacc cattcctcct ggcagagagt gatgaggcca aagtgcagcg
601 ggcagcagcc ggggttgggg gcagcttgcg ggcccaggtg gagcgattgc gggtggagct
661 gcagcgggag cggcggcggg gtgaggagca gcgggacagc tttgaggggg agcggctggc
721 ctggcaggca gagaaggagc aggtgatccg ctaccagaag cagctgcagc acaactacat
781 ccagatgtac cggcgcaacc ggcagctaga gcaggagctg cagcagctca gcctggagct
841 ggaggcccgg gagctcgctg acctgggcct ggccgagcag gccccctgca tctgcctgga
901 ggagatcact gctactgaga tctagggccc tcagcaacca gctctgtagg gagctctgcc
961 agaggggcag cagctgcaga tccacttagg ccccagggtc cacggatggc cccaaaggct
1021 gagggcccca aagccacttg tctcctagga tccaggcctc tgggcttctg ccaagaactc
1081 agggtggccc tatgacttgg aggagcaaga tcagaccgct caaaggtccc cgtgttcact
1141 gttacccaga ggctcttgtt actacccact tcattcccca ccgctgccag tgccactgcc
1201 aaccctgttc acaggcgctt ccagcccact ccagccaggg gagcagggaa gaagaagggg
1261 ctccctcctc ttcacattcc ccccgacccc aaagccagag aaagccagat ggcaccagct
1321 gctccggatg tgcctgccca cattggggga cagggccggg cctgggctcg gttcccaggt
1381 ttgagctctg cagcctctct cctggagtga gggggctgaa gtcagaccaa aggaagaact
1441 cagaaatgtc ttgtttattt gtgtttgtga ccaagcagcc tctcccttca cccaggttta
1501 tggcctcgtt ttcacttgta tatttttcac actgtaaatt tcttgtacaa acccaaagaa
1561 aaaattaaaa aaaatttttt tgtttaaaaa aaaaaaaaaa aaa
//