LOCUS       BC005815                2402 bp    mRNA    linear   HUM 15-JUL-2006
DEFINITION  Homo sapiens proprotein convertase subtilisin/kexin type 2, mRNA
            (cDNA clone MGC:10713 IMAGE:3937444), complete cds.
ACCESSION   BC005815
VERSION     BC005815.2
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2402)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 2402)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (02-APR-2001) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     On Aug 20, 2003 this sequence version replaced BC005815.1.
            Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: DCTD/DTP
            cDNA Library Preparation: Rubin Laboratory
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: Institute for Systems Biology
            http://www.systemsbiology.org
            contact: amadan@systemsbiology.org
            Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha
            Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAL Plate: 14 Row: l Column: 16
            This clone was selected for full length sequencing because it
            passed the following selection criteria: matched mRNA gi: 20336243.
FEATURES             Location/Qualifiers
     source          1..2402
                     /db_xref="H-InvDB:HIT000032455"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:10713 IMAGE:3937444"
                     /tissue_type="Lung, small cell carcinoma"
                     /clone_lib="NIH_MGC_7"
                     /lab_host="DH10B-R"
                     /note="Vector: pOTB7"
     gene            1..2402
                     /gene="PCSK2"
                     /gene_synonym="PC2"
                     /gene_synonym="SPC2"
                     /db_xref="GeneID:5126"
                     /db_xref="HGNC:HGNC:8744"
                     /db_xref="MIM:162151"
     CDS             256..2172
                     /gene="PCSK2"
                     /gene_synonym="PC2"
                     /gene_synonym="SPC2"
                     /codon_start=1
                     /product="proprotein convertase subtilisin/kexin type 2"
                     /protein_id="AAH05815.1"
                     /db_xref="GeneID:5126"
                     /db_xref="HGNC:HGNC:8744"
                     /db_xref="MIM:162151"
                     /translation="MKGGCVSQWKAAAGFLFCVMVFASAERPVFTNHFLVELHKGGED
                     KARQVAAEHGFGVRKLPFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQE
                     GFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKG
                     VTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSA
                     AANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGK
                     TVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSA
                     INDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAG
                     VFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAG
                     AMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDACEGKENFVRYLEHVQ
                     AVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARG
                     TWTLELGFVGSAPQKGVLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSKKEELEEELD
                     EAVERSLKSILNKN"
BASE COUNT          595 a          680 c          627 g          500 t
ORIGIN      
        1 ccggtacaca cagctcccca cattctcacc cctgcccgcg cgccgggccg cctgactgca
       61 cggcttcccc tccagccaga tgctggagaa cacacactga ttcgctgctt tccaagaccc
      121 tgttcagtct ctttctctat acaaagattt ttttaaaaac tatatataag aattctttat
      181 ttgcaccctc cctccgagtc ccctgctccg ccagcctgcg cgcctcctag caccactttt
      241 cactcccaaa gaaggatgaa gggtggttgt gtctcccagt ggaaggcggc cgccgggttc
      301 ctcttctgtg tcatggtttt tgcatctgct gagcgaccgg tcttcacgaa tcattttctt
      361 gtggagttgc ataaaggggg agaggacaaa gctcgccaag ttgcagcaga acacggcttt
      421 ggagtccgaa agcttccctt tgctgaaggt ctgtaccact tttatcacaa tggccttgca
      481 aaggccaaga gaagacgcag cctacaccac aagcagcagc tggagagaga ccccagggta
      541 aagatggctt tgcagcagga aggatttgac cgaaaaaagc gaggttacag agacatcaat
      601 gagatcgaca tcaacatgaa cgatcctctt tttacaaagc agtggtatct gatcaatact
      661 gggcaagctg atggcactcc tggccttgat ttgaatgtgg ctgaagcctg ggagctggga
      721 tacacaggga aaggtgttac cattggaatt atggatgatg ggattgacta tctccacccg
      781 gacctggcct ccaactataa tgccgaagca agttacgact tcagcagcaa cgacccctat
      841 ccttaccctc ggtacacaga tgactggttt aacagccacg ggacccgatg tgcaggagaa
      901 gtttctgctg ccgccaacaa caatatctgt ggagttggag tagcatacaa ctccaaggtt
      961 gcaggcatcc ggatgctgga ccagccattc atgacagaca tcatcgaggc ctcctccatc
     1021 agtcatatgc cacagctgat tgacatctac agcgccagct ggggccccac agacaacggc
     1081 aagacagtgg atgggccccg ggagctcacg ctgcaggcca tggccgatgg cgtgaacaag
     1141 ggccgcggcg gcaaaggcag catctacgtg tgggcctccg gggacggcgg cagctatgac
     1201 gactgcaact gcgacggcta cgcctccagc atgtggacca tctccatcaa ctcagccatc
     1261 aacgacggca ggactgccct gtacgacgag agctgctctt ccaccttggc ttccaccttc
     1321 agcaacggga ggaaaaggaa ccccgaggcc ggtgtggcaa ccacagattt gtacggcaac
     1381 tgcactctga ggcattctgg gacatctgca gctgcccccg aggcagctgg tgtgtttgca
     1441 ctggctctgg aggctaacct gggtctgacc tggcgggaca tgcagcatct gactgtgctc
     1501 acctccaaac ggaaccagct tcacgacgag gtccatcagt ggcggcgcaa tggggtcggc
     1561 ctggaattta atcacctctt tggctacggg gtccttgatg caggtgccat ggtgaaaatg
     1621 gctaaagact ggaaaaccgt gcctgagaga ttccactgtg tgggaggctc cgtgcaggac
     1681 cctgagaaaa taccatccac tggcaagttg gtgctgacac tcacaaccga cgcctgtgag
     1741 gggaaggaaa attttgtccg ctacctggag catgtccagg ctgtcatcac ggtcaacgca
     1801 accagaagag gagacctgaa catcaacatg acttccccta tgggcaccaa gtccattttg
     1861 ctgagccggc gtccaaggga tgacgactcc aaggtgggct ttgacaagtg gcctttcatg
     1921 accactcaca cgtgggggga agacgcccga ggcacctgga ccctggagct gggatttgtc
     1981 ggcagcgccc cgcagaaggg ggtgctgaag gagtggaccc tgatgctgca tggcactcag
     2041 agtgccccgt acatcgacca ggtggtgcgg gattaccagt ccaagttggc catgtccaag
     2101 aaagaggagc tggaggaaga gctggacgaa gccgtggaga gaagcctgaa aagcatcctt
     2161 aacaagaact agcgctgcac atccgccttt cccaccgccc tccctcccca gctccgcctc
     2221 tgtcctcgct ccacgtttca ggcaggcacc tagcaattcc atcacccgta caggcaattc
     2281 cgtcttctta atctgaagct tcactcactg tcaatgatta ttttcattac aatggaaaca
     2341 atctttttta ctctatgccc caaatatagc gttcccaaca acaaaaaaaa aaaaaaaaaa
     2401 aa
//