LOCUS BC005815 2402 bp mRNA linear HUM 15-JUL-2006 DEFINITION Homo sapiens proprotein convertase subtilisin/kexin type 2, mRNA (cDNA clone MGC:10713 IMAGE:3937444), complete cds. ACCESSION BC005815 VERSION BC005815.2 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2402) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. CONSRTM Mammalian Gene Collection Program Team TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 2402) CONSRTM NIH MGC Project TITLE Direct Submission JOURNAL Submitted (02-APR-2001) National Institutes of Health, Mammalian Gene Collection (MGC), Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT On Aug 20, 2003 this sequence version replaced BC005815.1. Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: DCTD/DTP cDNA Library Preparation: Rubin Laboratory cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: Institute for Systems Biology http://www.systemsbiology.org contact: amadan@systemsbiology.org Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAL Plate: 14 Row: l Column: 16 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi: 20336243. FEATURES Location/Qualifiers source 1..2402 /db_xref="H-InvDB:HIT000032455" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:10713 IMAGE:3937444" /tissue_type="Lung, small cell carcinoma" /clone_lib="NIH_MGC_7" /lab_host="DH10B-R" /note="Vector: pOTB7" gene 1..2402 /gene="PCSK2" /gene_synonym="PC2" /gene_synonym="SPC2" /db_xref="GeneID:5126" /db_xref="HGNC:HGNC:8744" /db_xref="MIM:162151" CDS 256..2172 /gene="PCSK2" /gene_synonym="PC2" /gene_synonym="SPC2" /codon_start=1 /product="proprotein convertase subtilisin/kexin type 2" /protein_id="AAH05815.1" /db_xref="GeneID:5126" /db_xref="HGNC:HGNC:8744" /db_xref="MIM:162151" /translation="MKGGCVSQWKAAAGFLFCVMVFASAERPVFTNHFLVELHKGGED KARQVAAEHGFGVRKLPFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQE GFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKG VTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSA AANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGK TVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSA INDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAG VFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAG AMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDACEGKENFVRYLEHVQ AVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARG TWTLELGFVGSAPQKGVLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSKKEELEEELD EAVERSLKSILNKN" BASE COUNT 595 a 680 c 627 g 500 t ORIGIN 1 ccggtacaca cagctcccca cattctcacc cctgcccgcg cgccgggccg cctgactgca 61 cggcttcccc tccagccaga tgctggagaa cacacactga ttcgctgctt tccaagaccc 121 tgttcagtct ctttctctat acaaagattt ttttaaaaac tatatataag aattctttat 181 ttgcaccctc cctccgagtc ccctgctccg ccagcctgcg cgcctcctag caccactttt 241 cactcccaaa gaaggatgaa gggtggttgt gtctcccagt ggaaggcggc cgccgggttc 301 ctcttctgtg tcatggtttt tgcatctgct gagcgaccgg tcttcacgaa tcattttctt 361 gtggagttgc ataaaggggg agaggacaaa gctcgccaag ttgcagcaga acacggcttt 421 ggagtccgaa agcttccctt tgctgaaggt ctgtaccact tttatcacaa tggccttgca 481 aaggccaaga gaagacgcag cctacaccac aagcagcagc tggagagaga ccccagggta 541 aagatggctt tgcagcagga aggatttgac cgaaaaaagc gaggttacag agacatcaat 601 gagatcgaca tcaacatgaa cgatcctctt tttacaaagc agtggtatct gatcaatact 661 gggcaagctg atggcactcc tggccttgat ttgaatgtgg ctgaagcctg ggagctggga 721 tacacaggga aaggtgttac cattggaatt atggatgatg ggattgacta tctccacccg 781 gacctggcct ccaactataa tgccgaagca agttacgact tcagcagcaa cgacccctat 841 ccttaccctc ggtacacaga tgactggttt aacagccacg ggacccgatg tgcaggagaa 901 gtttctgctg ccgccaacaa caatatctgt ggagttggag tagcatacaa ctccaaggtt 961 gcaggcatcc ggatgctgga ccagccattc atgacagaca tcatcgaggc ctcctccatc 1021 agtcatatgc cacagctgat tgacatctac agcgccagct ggggccccac agacaacggc 1081 aagacagtgg atgggccccg ggagctcacg ctgcaggcca tggccgatgg cgtgaacaag 1141 ggccgcggcg gcaaaggcag catctacgtg tgggcctccg gggacggcgg cagctatgac 1201 gactgcaact gcgacggcta cgcctccagc atgtggacca tctccatcaa ctcagccatc 1261 aacgacggca ggactgccct gtacgacgag agctgctctt ccaccttggc ttccaccttc 1321 agcaacggga ggaaaaggaa ccccgaggcc ggtgtggcaa ccacagattt gtacggcaac 1381 tgcactctga ggcattctgg gacatctgca gctgcccccg aggcagctgg tgtgtttgca 1441 ctggctctgg aggctaacct gggtctgacc tggcgggaca tgcagcatct gactgtgctc 1501 acctccaaac ggaaccagct tcacgacgag gtccatcagt ggcggcgcaa tggggtcggc 1561 ctggaattta atcacctctt tggctacggg gtccttgatg caggtgccat ggtgaaaatg 1621 gctaaagact ggaaaaccgt gcctgagaga ttccactgtg tgggaggctc cgtgcaggac 1681 cctgagaaaa taccatccac tggcaagttg gtgctgacac tcacaaccga cgcctgtgag 1741 gggaaggaaa attttgtccg ctacctggag catgtccagg ctgtcatcac ggtcaacgca 1801 accagaagag gagacctgaa catcaacatg acttccccta tgggcaccaa gtccattttg 1861 ctgagccggc gtccaaggga tgacgactcc aaggtgggct ttgacaagtg gcctttcatg 1921 accactcaca cgtgggggga agacgcccga ggcacctgga ccctggagct gggatttgtc 1981 ggcagcgccc cgcagaaggg ggtgctgaag gagtggaccc tgatgctgca tggcactcag 2041 agtgccccgt acatcgacca ggtggtgcgg gattaccagt ccaagttggc catgtccaag 2101 aaagaggagc tggaggaaga gctggacgaa gccgtggaga gaagcctgaa aagcatcctt 2161 aacaagaact agcgctgcac atccgccttt cccaccgccc tccctcccca gctccgcctc 2221 tgtcctcgct ccacgtttca ggcaggcacc tagcaattcc atcacccgta caggcaattc 2281 cgtcttctta atctgaagct tcactcactg tcaatgatta ttttcattac aatggaaaca 2341 atctttttta ctctatgccc caaatatagc gttcccaaca acaaaaaaaa aaaaaaaaaa 2401 aa //