LOCUS BC005387 1386 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens aldo-keto reductase family 1, member B1 (aldose
reductase), mRNA (cDNA clone MGC:12512 IMAGE:3960811), complete
cds.
ACCESSION BC005387
VERSION BC005387.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1386)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1386)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (27-MAR-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: CLONTECH Laboratories, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 16 Row: e Column: 18
This clone was selected for full length sequencing because it
passed the following selection criteria: Hexamer frequency ORF
analysis, Similarity but not identity to protein.
FEATURES Location/Qualifiers
source 1..1386
/db_xref="H-InvDB:HIT000032430"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:12512 IMAGE:3960811"
/tissue_type="Bladder, carcinoma"
/clone_lib="NIH_MGC_53"
/lab_host="DH10B"
/note="Vector: pDNR-LIB"
gene 1..1386
/gene="AKR1B1"
/gene_synonym="ADR"
/gene_synonym="AR"
/gene_synonym="MGC1804"
/db_xref="GeneID:231"
/db_xref="HGNC:HGNC:381"
/db_xref="MIM:103880"
CDS 39..989
/gene="AKR1B1"
/gene_synonym="ADR"
/gene_synonym="AR"
/gene_synonym="MGC1804"
/codon_start=1
/product="aldo-keto reductase family 1, member B1 (aldose
reductase)"
/protein_id="AAH05387.1"
/db_xref="GeneID:231"
/db_xref="HGNC:HGNC:381"
/db_xref="MIM:103880"
/translation="MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHID
CAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKL
DYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTRAAMEELVDEGLVKAIGIS
NFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDR
PWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKV
FDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF"
BASE COUNT 349 a 354 c 367 g 316 t
ORIGIN
1 gcaccgtact gggcgggggt ctggggagcg cagcagccat ggctagccgt ctcctgctca
61 acaacggcgc caagatgccc atcctggggt tgggtacctg gaagtcccct ccagggcagg
121 tgactgaggc cgtgaaggtg gccattgacg tcgggtaccg ccacatcgac tgtgcccatg
181 tgtaccagaa tgagaatgag gtgggggtgg ccattcagga gaagctcagg gagcaggtgg
241 tgaagcgtga ggagctcttc atcgtcagca agctgtggtg cacgtaccat gagaagggcc
301 tggtgaaagg agcctgccag aagacactca gcgacctgaa gctggactac ctggacctct
361 accttattca ctggccgact ggctttaagc ctgggaagga atttttccca ttggatgagt
421 cgggcaatgt ggttcccagt gacaccaaca ttctggacac gcgggcggcc atggaagagc
481 tggtggatga agggctggtg aaagctattg gcatctccaa cttcaaccat ctccaggtgg
541 agatgatctt aaacaaacct ggcttgaagt ataagcctgc agttaaccag attgagtgcc
601 acccatatct cactcaggag aagttaatcc agtactgcca gtccaaaggc atcgtggtga
661 ccgcctacag ccccctcggc tctcctgaca ggccctgggc caagcccgag gacccttctc
721 tcctggagga tcccaggatc aaggcgatcg cagccaagca caataaaact acagcccagg
781 tcctgatccg gttccccatg cagaggaact tggtggtgat ccccaagtct gtgacaccag
841 aacgcattgc tgagaacttt aaggtctttg actttgaact gagcagccag gatatgacca
901 ccttactcag ctacaacagg aactggaggg tctgtgcctt gttgagctgt acctcccaca
961 aggattaccc cttccatgaa gagttttgaa gctgtggttg cctgctcgtc cccaagtgac
1021 ctatacctgt gtttcttgcc tcattttttt ccttgcaaat gtagtatggc ctgtgtcact
1081 cagcagtggg acagcaacct gtagagtggc cagcgagggc gtgtctagct tgatgttgga
1141 tctcaagagc cctgtcagta gagtagaagt ctcttccagt ttgctttgcc cttctttcta
1201 ccctgctggg gaaagtacaa cctgaatacc cttttctgac caaagagaag caaaatctac
1261 caggtcaaaa tagtgccact aacggttgag ttttgactgc ttggaactgg aatcctttca
1321 gcaagacttc tctttgcctc aaataaaaag tgcttttaaa aaaaaaaaaa aaaaaaaaaa
1381 aaaaaa
//