LOCUS BC004371 1862 bp mRNA linear HUM 03-OCT-2003
DEFINITION Homo sapiens amyloid beta (A4) precursor-like protein 2, mRNA (cDNA
clone MGC:10449 IMAGE:3640033), complete cds.
ACCESSION BC004371
VERSION BC004371.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1862)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1862)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (12-MAR-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Steven Jones, Jennifer Asano, Ian Bosdet, Yaron Butterfield,
Susanna Chan, Readman Chiu, Chris Fjell, Erin Garland, Ran Guin,
Letticia Hsiao, Martin Krzywinski, Reta Kutsche, Oliver Lee, Soo
Sen Lee, Victor Ling, Carrie Mathewson, Candice McLeavy, Steven
Ness, Pawan Pandoh, Anna-Liisa Prabhu, Parvaneh Saeedi, Jacqueline
Schein, Duane Smailus, Michael Smith, Lorraine Spence, Jeff Stott,
Michael Thorne, Miranada Tsai, Natasja van den Bosch, Jill Vardy,
George Yang, Scott Zuyderduyn, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 13 Row: f Column: 16
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 4502146.
FEATURES Location/Qualifiers
source 1..1862
/db_xref="H-InvDB:HIT000031896"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:10449 IMAGE:3640033"
/tissue_type="Pancreas, adenocarcinoma"
/clone_lib="NIH_MGC_39"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..1862
/gene="APLP2"
/gene_synonym="APPH"
/gene_synonym="APPL2"
/gene_synonym="CDEBP"
/db_xref="GeneID:334"
/db_xref="MIM:104776"
CDS 63..1631
/gene="APLP2"
/gene_synonym="APPH"
/gene_synonym="APPL2"
/gene_synonym="CDEBP"
/codon_start=1
/product="APLP2 protein"
/protein_id="AAH04371.1"
/db_xref="GeneID:334"
/db_xref="MIM:104776"
/translation="MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTG
FAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITN
VMEANQRVSIDNWCRRDKKQCKSRFVTPFKCLVPPTPLPTNDVDVYFETSADDNEHAR
FQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAAS
EKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALRRYVRAENKDRL
HTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQTLSLLYKVPYVAQEIQEEIDE
LLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFHPFPALPENEGSGVGEQDG
GLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLEEERESVGPLREDFSLS
SSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHG
YENPTYKYLEQMQI"
misc_feature 186..473
/gene="APLP2"
/gene_synonym="APPH"
/gene_synonym="APPL2"
/gene_synonym="CDEBP"
/note="A4_EXTRA; Region: Amyloid A4 extracellular domain"
/db_xref="CDD:pfam02177"
BASE COUNT 505 a 454 c 529 g 374 t
ORIGIN
1 gctaagcgag gagtctgagt gtgtgagctt gagagccgcg cgctagagcg acccggcgag
61 ggatggcggc caccgggacc gcggccgccg cagccacggg caggctcctg cttctgctgc
121 tggtggggct cacggcgcct gccttggcgc tggccggcta catcgaggct cttgcagcca
181 atgccggaac aggatttgct gttgctgagc ctcaaatcgc aatgttttgt gggaagttaa
241 atatgcatgt gaacattcag actgggaaat gggaacctga tccaacaggc accaagagct
301 gctttgaaac aaaagaagaa gttcttcagt actgtcagga gatgtatcca gagctacaga
361 tcacaaatgt gatggaggca aaccagcggg ttagtattga caactggtgc cggagggaca
421 aaaagcaatg caagagtcgc tttgttacac ctttcaagtg tctcgttcct ccaactcctc
481 tgccaaccaa tgatgttgat gtgtatttcg agacctctgc agatgataat gagcatgctc
541 gcttccagaa ggctaaggag cagctggaga ttcggcaccg caaccgaatg gacagggtaa
601 agaaggaatg ggaagaggca gagcttcaag ctaagaacct ccccaaagca gagaggcaga
661 ctctgattca gcacttccaa gccatggtta aagctttaga gaaggaagca gccagtgaga
721 agcagcagct ggtggagacc cacctggccc gagtggaagc tatgctgaat gaccgccgtc
781 ggatggctct ggagaactac ctggctgcct tgcagtctga cccgccacgg cctcatcgca
841 ttctccaggc cttacggcgt tatgtccgtg ctgagaacaa agatcgctta cataccatcc
901 gtcattacca gcacgtgttg gctgttgacc cagaaaaggc ggcccagatg aaatcccagg
961 tgatgacaca tctccacgtg attgaagaaa ggaggaacca aaccctctct ctgctctaca
1021 aagtacctta tgtagcccaa gaaattcaag aggaaattga tgagctcctt caggagcagc
1081 gtgcagatat ggaccagttc actgcctcaa tctcagagac ccctgtggac gtccgggtga
1141 gctctgagga gagtgaggag atcccaccgt tccacccctt ccaccccttc ccagccctac
1201 ctgagaacga aggatctgga gtgggagagc aggatggggg actgatcggt gccgaagaga
1261 aagtgattaa cagtaagaat aaagtggatg aaaacatggt cattgacgag actctggatg
1321 ttaaggaaat gattttcaat gccgagagag ttggaggcct cgaggaagag cgggaatccg
1381 tgggcccact gcgggaggac ttcagtctga gtagcagtgc tctcattggc ctgctggtca
1441 tcgcagtggc cattgccacg gtcatcgtca tcagcctggt gatgctgagg aagaggcagt
1501 atggcaccat cagccacggg atcgtggagg ttgatccaat gctcacccca gaagagcgtc
1561 acctgaacaa gatgcagaac catggctatg agaaccccac ctacaaatac ctggagcaga
1621 tgcagattta ggtggcaggg agcgcggcag ccctggcgga gggatgcagg tgggccggaa
1681 gatcccacga ttccgatcga ctgccaagca gcagccgctg ccaggggctg cgtctgacat
1741 cctgacctcc tggactgtag gactatataa agtactactg tagaactgca atttccattc
1801 ttttaaatgg gtgaaaaatg gtaatataac aatatatgat atataaaaaa aaaaaaaaaa
1861 aa
//