LOCUS BC004311 1760 bp mRNA linear HUM 01-SEP-2006
DEFINITION Homo sapiens potassium voltage-gated channel, subfamily H
(eag-related), member 2, mRNA (cDNA clone IMAGE:3627585), partial
cds.
ACCESSION BC004311
VERSION BC004311.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1760)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1760)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (01-MAR-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Sep 16, 2003 this sequence version replaced BC004311.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 13 Row: i Column: 10.
FEATURES Location/Qualifiers
source 1..1760
/db_xref="H-InvDB:HIT000086331"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:3627585"
/tissue_type="Brain, neuroblastoma"
/clone_lib="NIH_MGC_19"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene <1..1760
/gene="KCNH2"
/gene_synonym="ERG1"
/gene_synonym="HERG"
/gene_synonym="HERG1"
/gene_synonym="Kv11.1"
/gene_synonym="SQT1"
/db_xref="GeneID:3757"
/db_xref="HGNC:HGNC:6251"
/db_xref="MIM:152427"
CDS <1..1335
/gene="KCNH2"
/gene_synonym="ERG1"
/gene_synonym="HERG"
/gene_synonym="HERG1"
/gene_synonym="Kv11.1"
/gene_synonym="SQT1"
/codon_start=1
/product="KCNH2 protein"
/protein_id="AAH04311.2"
/db_xref="GeneID:3757"
/db_xref="HGNC:HGNC:6251"
/db_xref="MIM:152427"
/translation="VLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFK
TTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGK
SNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGST
ELEGGFSRQRKRKLSFRRRTDTDTEQPGEVSALGPGRAGAGPSSRGRPGGPWGESPSS
GPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGAF
SGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQL
NRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDS
LSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS"
BASE COUNT 334 a 591 c 537 g 298 t
ORIGIN
1 gtgctgaagg gcttccctga gtgcctgcag gctgacatct gcctgcacct gaaccgctca
61 ctgctgcagc actgcaaacc cttccgaggg gccaccaagg gctgccttcg ggccctggcc
121 atgaagttca agaccacaca tgcaccgcca ggggacacac tggtgcatgc tggggacctg
181 ctcaccgccc tgtacttcat ctcccggggc tccatcgaga tcctgcgggg cgacgtcgtc
241 gtggccatcc tggggaagaa tgacatcttt ggggagcctc tgaacctgta tgcaaggcct
301 ggcaagtcga acggggatgt gcgggccctc acctactgtg acctacacaa gatccatcgg
361 gacgacctgc tggaggtgct ggacatgtac cctgagttct ccgaccactt ctggtccagc
421 ctggagatca ccttcaacct gcgagatacc aacatgatcc cgggctcccc cggcagtacg
481 gagttagagg gtggcttcag tcggcaacgc aagcgcaagt tgtccttccg caggcgcacg
541 gacacggaca cggagcagcc aggggaggtg tcggccttgg ggccgggccg ggcgggggca
601 gggccgagta gccggggccg gccggggggg ccgtgggggg agagcccgtc cagtggcccc
661 tccagccctg agagcagtga ggatgagggc ccaggccgca gctccagccc cctccgcctg
721 gtgcccttct ccagccccag gccccccgga gagccgccgg gtggggagcc cctgatggag
781 gactgcgaga agagcagcga cacttgcaac cccctgtcag gcgccttctc aggagtgtcc
841 aacattttca gcttctgggg ggacagtcgg ggccgccagt accaggagct ccctcgatgc
901 cccgccccca cccccagcct cctcaacatc cccctctcca gcccgggtcg gcggccccgg
961 ggcgacgtgg agagcaggct ggatgccctc cagcgccagc tcaacaggct ggagacccgg
1021 ctgagtgcag acatggccac tgtcctgcag ctgctacaga ggcagatgac gctggtcccg
1081 cccgcctaca gtgctgtgac caccccgggg cctggcccca cttccacatc cccgctgttg
1141 cccgtcagcc ccctccccac cctcaccttg gactcgcttt ctcaggtttc ccagttcatg
1201 gcgtgtgagg agctgccccc gggggcccca gagcttcccc aagaaggccc cacacgacgc
1261 ctctccctac cgggccagct gggggccctc acctcccagc ccctgcacag acacggctcg
1321 gacccgggca gttagtgggg ctgcccagtg tggacacgtg gctcacccag ggatcaaggc
1381 gctgctgggc cgctcccctt ggaggccctg ctcaggaggc cctgaccgtg gaaggggaga
1441 ggaactcgaa agcacagctc ctcccccagc ccttgggacc atcttctcct gcagtcccct
1501 gggccccagt gagaggggca ggggcagggc cggcagtagg tggggcctgt ggtcccccca
1561 ctgccctgag ggcattagct ggtctaactg cccggaggca cccggccctg ggccttaggc
1621 acctcaagga cttttctgct atttactgct cttattgtta aggataataa ttaaggatca
1681 tatgaataat taatgaagat gctgatgact atgaataata aataattatc ctgaggagaa
1741 aaaaaaaaaa aaaaaaaaaa
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