LOCUS BC003512 2433 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens mesothelin, mRNA (cDNA clone MGC:10686 IMAGE:3611296),
complete cds.
ACCESSION BC003512
VERSION BC003512.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2433)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2433)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (20-FEB-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 13 Row: a Column: 21
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 68303642.
FEATURES Location/Qualifiers
source 1..2433
/db_xref="H-InvDB:HIT000031568"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:10686 IMAGE:3611296"
/tissue_type="Pancreas, adenocarcinoma"
/clone_lib="NIH_MGC_39"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..2433
/gene="MSLN"
/gene_synonym="CAK1"
/gene_synonym="MPF"
/gene_synonym="SMR"
/db_xref="GeneID:10232"
/db_xref="HGNC:HGNC:7371"
/db_xref="MIM:601051"
CDS 418..2283
/gene="MSLN"
/gene_synonym="CAK1"
/gene_synonym="MPF"
/gene_synonym="SMR"
/codon_start=1
/product="mesothelin"
/protein_id="AAH03512.1"
/db_xref="GeneID:10232"
/db_xref="HGNC:HGNC:7371"
/db_xref="MIM:601051"
/translation="MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQA
APLDGVLANPPNISSLSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRC
LAHRLSEPPEDLDALPLDLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQR
LLPAALACWGVRGSLLSEADVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQ
QEAARAALQGGGPPYGPPSTWSVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSR
DPSWRQPERTILRPRFRREVEKTACPSGKKAREIDESLIFYKKWELEACVDAALLATQ
MDRVNAIPFTYEQLDVLKHKLDELYPQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLE
TLKALLEVNKGHEMSPQVATLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSS
VPPSSIWAVRPQDLDTCDPRQLDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLK
ALSQQNVSMDLATFMKLRTDAVLPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQR
QDDLDTLGLGLQGGIPNGYLVLDLSVQEALSGTPCLLGPGPVLTVLALLLASTLA"
BASE COUNT 431 a 823 c 755 g 424 t
ORIGIN
1 ccaggctctc cacccccact tcccaattga ggaaaccgag gcagaggagg ctcaggtgtg
61 gccaatcacc ctgcacatca gagttaccct gggcagggcc cactgagacc tgggaggggc
121 cactcgggac ctggagggct gggggctgcc cgggcgttag gggtaaagct ccctacccaa
181 ctgcgcagaa ggcctcagag gcctgggggc tgggcttccc ctttcacatc gccctttaga
241 ggcccacgtg tgggcattgg cccgcgatct gaaaggggct gtcctgttcc tcatgggcgc
301 tgccagcgcc acgcactcct ctttctgcct ggccggccac tcccgtctgc tgtgacgcgc
361 ggacagagag ctaccggtgg acccacggtg cctccctccc tgggatctac acagaccatg
421 gccttgccaa cggctcgacc cctgttgggg tcctgtggga cccccgccct cggcagcctc
481 ctgttcctgc tcttcagcct cggatgggtg cagccctcga ggaccctggc tggagagaca
541 gggcaggctg cacccctgga cggagtcctg gccaacccac ctaacatttc cagcctctcc
601 cctcgccaac tccttggctt cccgtgtgcg gaggtgtccg gcctgagcac ggagcgtgtc
661 cgggagctgg ctgtggcctt ggcacagaag aatgtcaagc tctcaacaga gcagctgcgc
721 tgtctggctc accggctctc tgagcccccc gaggacctgg acgccctccc attggacctg
781 ctgctattcc tcaacccaga tgcgttctcg gggccccagg cctgcacccg tttcttctcc
841 cgcatcacga aggccaatgt ggacctgctc ccgagggggg ctcccgagcg acagcggctg
901 ctgcctgcgg ctctggcctg ctggggtgtg cgggggtctc tgctgagcga ggctgatgtg
961 cgggctctgg gaggcctggc ttgcgacctg cctgggcgct ttgtggccga gtcggccgaa
1021 gtgctgctac cccggctggt gagctgcccg ggacccctgg accaggacca gcaggaggca
1081 gccagggcgg ctctgcaggg cgggggaccc ccctacggcc ccccgtcgac atggtctgtc
1141 tccacgatgg acgctctgcg gggcctgctg cccgtgctgg gccagcccat catccgcagc
1201 atcccgcagg gcatcgtggc cgcgtggcgg caacgctcct ctcgggaccc atcctggcgg
1261 cagcctgaac ggaccatcct ccggccgcgg ttccggcggg aagtggagaa gacagcctgt
1321 ccttcaggca agaaggcccg cgagatagac gagagcctca tcttctacaa gaagtgggag
1381 ctggaagcct gcgtggatgc ggccctgctg gccacccaga tggaccgcgt gaacgccatc
1441 cccttcacct acgagcagct ggacgtccta aagcataaac tggatgagct ctacccacaa
1501 ggttaccccg agtctgtgat ccagcacctg ggctacctct tcctcaagat gagccctgag
1561 gacattcgca agtggaatgt gacgtccctg gagaccctga aggctttgct tgaagtcaac
1621 aaagggcacg aaatgagtcc tcaggtggcc accctgatcg accgctttgt gaagggaagg
1681 ggccagctag acaaagacac cctagacacc ctgaccgcct tctaccctgg gtacctgtgc
1741 tccctcagcc ccgaggagct gagctccgtg ccccccagca gcatctgggc ggtcaggccc
1801 caggacctgg acacgtgtga cccaaggcag ctggacgtcc tctatcccaa ggcccgcctt
1861 gctttccaga acatgaacgg gtccgaatac ttcgtgaaga tccagtcctt cctgggtggg
1921 gcccccacgg aggatttgaa ggcgctcagt cagcagaatg tgagcatgga cttggccacg
1981 ttcatgaagc tgcggacgga tgcggtgctg ccgttgactg tggctgaggt gcagaaactt
2041 ctgggacccc acgtggaggg cctgaaggcg gaggagcggc accgcccggt gcgggactgg
2101 atcctacggc agcggcagga cgacctggac acgctggggc tggggctaca gggcggcatc
2161 cccaacggct acctggtcct agacctcagc gtgcaagagg ccctctcggg gacgccctgc
2221 ctcctaggac ctggacctgt tctcaccgtc ctggcactgc tcctagcctc caccctggcc
2281 tgagggcccc actcccttgc tggccccagc cctgctgggg atccccgcct ggccaggagc
2341 aggcacgggt gatccccgtt ccaccccaag agaactcgcg ctcagtaaac gggaacatgc
2401 cccctgcaga cacgtaaaaa aaaaaaaaaa aaa
//