LOCUS BC002767 2601 bp mRNA linear HUM 06-APR-2004
DEFINITION Homo sapiens LATS, large tumor suppressor, homolog 1 (Drosophila),
mRNA (cDNA clone MGC:3608 IMAGE:3632571), complete cds.
ACCESSION BC002767
VERSION BC002767.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2601)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2601)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (05-FEB-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 12 Row: o Column: 22
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 10862687.
FEATURES Location/Qualifiers
source 1..2601
/db_xref="H-InvDB:HIT000258892"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:3608 IMAGE:3632571"
/tissue_type="Uterus, endometrium adenocarcinoma"
/clone_lib="NIH_MGC_44"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..2601
/gene="LATS1"
/gene_synonym="WARTS"
/gene_synonym="wts"
/db_xref="GeneID:9113"
/db_xref="MIM:603473"
CDS 407..2479
/gene="LATS1"
/gene_synonym="WARTS"
/gene_synonym="wts"
/codon_start=1
/product="LATS1 protein"
/protein_id="AAH02767.1"
/db_xref="GeneID:9113"
/db_xref="MIM:603473"
/translation="MKRSEKPEGYRQMRPKTFPASNYTVSSRQMLQEIRESLRNLSKP
SDAAKAEHNMSKMSTEDPRQVRNPPKFGTHHKALQEIRNSLLPFANETNSSRSTSEVN
PQMLQDLQAAGFDEDMVIQALQKTNNRSIEAAIEFISKMSYQDPRREQMAAAAARPIN
ASMKPGNVQQSVNRKQSWKGSKESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGS
GISAFVQAHPSNGQRVNPPPPPQVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKR
YSGNMEYVISRISPVPPGAWQEGYPPPPLNTSPMNPPNQGQRGISSVPVGRQPIIMQS
SSKFNFPSGRPGMQNGTGQTDFMIHQNVVPAGTVNRQPPPPYPLTAANGQSPSALQTG
GSAAPSSYTNGSIPQSMMVPNRNSHNMELYNISVPGLQTNWPQSSSAPAQSSPSSGHE
IPTWQPNIPVRSNSFNNPLGNRASHSANSQPSATTVTAITPAPIQQPVKSMRVLKPEL
QTALAPTHPSWIPQPIQTVQPSPFPEGTASNVTVMPPVAEAPNYQGPPPPYPKHLLHQ
NPSVPPYESISKPSKEDQPSLPKEDESEKSYENVDSGDKEKKQITTSPITVRKNKKDE
ERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRVKPFKMSIFILN
HLFAWCLF"
misc_feature 707..820
/gene="LATS1"
/gene_synonym="WARTS"
/gene_synonym="wts"
/note="UBA; Region: UBA/TS-N domain. This small domain is
composed of three alpha helices. This family includes the
previously defined UBA and TS-N domains. The UBA-domain
(ubiquitin associated domain) is a novel sequence motif
found in several proteins having connections to ubiquitin
and the ubiquitination pathway. The structure of the UBA
domain consists of a compact three helix bundle. This
domain is found at the N terminus of EF-TS hence the name
TS-N. The structure of EF-TS is known and this domain is
implicated in its interaction with EF-TU. The domain has
been found in non EF-TS proteins such as alpha-NAC and
MJ0280"
/db_xref="CDD:pfam00627"
BASE COUNT 805 a 636 c 532 g 628 t
ORIGIN
1 ggcacgaggc tgcagcggag tgcggcggcg gcgacactga gtggaaggca aaatggcggc
61 ggcggcggcg gtggcctggt gttaagggga gagccaggtc cttacgaccc ctgggacggg
121 ccgcgctggc ccgcggcagc ccccccgttc gtctccccgc tctgccccac cagggatact
181 tggggttgct gggacggact ctggccgcct cagcgtccgc cctcaggccc gtggccgctg
241 tccaggagct ctgctctccc ctccagagtt aattatttat attgtaaaga attttaacag
301 tcctggggac ttccttgaag catcattttc acttttgctc agaagaaagc tctggatcta
361 tcaaataaag aagtccttcg tgtgggctac atatatagat gttttcatga agaggagtga
421 aaagccagaa ggatatagac aaatgaggcc taagaccttt cctgccagta actatactgt
481 cagtagccgg caaatgttac aagaaattcg ggaatccctt aggaatttat ctaaaccatc
541 tgatgctgct aaggctgagc ataacatgag taaaatgtca accgaagatc ctcgacaagt
601 cagaaatcca cccaaatttg ggacgcatca taaagccttg caggaaattc gaaactctct
661 gcttccattt gcaaatgaaa caaattcttc tcggagtact tcagaagtta atccacaaat
721 gcttcaagac ttgcaagctg ctggatttga tgaggatatg gttatacaag ctcttcagaa
781 aactaacaac agaagtatag aagcagcaat tgaattcatt agtaaaatga gttaccaaga
841 tcctcgacga gagcagatgg ctgcagcagc tgccagacct attaatgcca gcatgaaacc
901 agggaatgtg cagcaatcag ttaaccgcaa acagagctgg aaaggttcta aagaatcctt
961 agttcctcag aggcatggcc cgccactagg agaaagtgtg gcctatcatt ctgagagtcc
1021 caactcacag acagatgtag gaagaccttt gtctggatct ggtatatcag catttgttca
1081 agctcaccct agcaacggac agagagtgaa ccccccacca ccacctcaag taaggagtgt
1141 tactcctcca ccacctccaa gaggccagac tccccctcca agaggtacaa ctccacctcc
1201 cccttcatgg gaaccaaact ctcaaacaaa gcgctattct ggaaacatgg aatacgtaat
1261 ctcccgaatc tctcctgtcc cacctggggc atggcaagag ggctatcctc caccacctct
1321 caacacttcc cccatgaatc ctcctaatca aggacagaga ggcattagtt ctgttcctgt
1381 tggcagacaa ccaatcatca tgcagagttc tagcaaattt aactttccat cagggagacc
1441 tggaatgcag aatggtactg gacaaactga tttcatgata caccaaaatg ttgtccctgc
1501 tggcactgtg aatcggcagc caccacctcc atatcctctg acagcagcta atggacaaag
1561 cccttctgct ttacaaacag ggggatctgc tgctccttcg tcatatacaa atggaagtat
1621 tcctcagtct atgatggtgc caaacagaaa tagtcataac atggaactat ataacattag
1681 tgtacctgga ctgcaaacaa attggcctca gtcatcttct gctccagccc agtcatcccc
1741 gagcagtggg catgaaatcc ctacatggca acctaacata ccagtgaggt caaattcttt
1801 taataaccca ttaggaaata gagcaagtca ctctgctaat tctcagcctt ccgctacaac
1861 agtcactgca attacaccag ctcctattca acagcctgtg aaaagtatgc gtgtattaaa
1921 accagagcta cagactgctt tagcacctac acacccttct tggataccac agccaattca
1981 aactgttcaa cccagtcctt ttcctgaggg aaccgcttca aatgtgactg tgatgccacc
2041 tgttgctgaa gctccaaact atcaaggacc accaccaccc tacccaaaac atctgctgca
2101 ccaaaaccca tctgttcctc catacgagtc aatcagtaag cctagcaaag aggatcagcc
2161 aagcttgccc aaggaagatg agagtgaaaa gagttatgaa aatgttgata gtggggataa
2221 agaaaagaaa cagattacaa cttcacctat tactgttagg aaaaacaaga aagatgaaga
2281 gcgaagggaa tctcgtattc aaagttattc tcctcaagca tttaaattct ttatggagca
2341 acatgtagaa aatgtactca aatctcatca gcagcgtcta catcgtaaaa aacaattaga
2401 gaatgaaatg atgcgggtaa aaccttttaa aatgtccatt tttatactta atcatctgtt
2461 tgcttggtgt ttattttaaa atattgtgtc cagtattttt ctttcttttt atagctaaat
2521 aaaatatatt atcagttatg gaatttaaaa gtgaataaat attaaagtac ttttgaaaaa
2581 aaaaaaaaaa aaaaaaaaaa a
//