LOCUS BC002576 3065 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens matrix metallopeptidase 2 (gelatinase A, 72kDa
gelatinase, 72kDa type IV collagenase), mRNA (cDNA clone MGC:2313
IMAGE:3161383), complete cds.
ACCESSION BC002576
VERSION BC002576.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3065)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3065)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (05-FEB-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Aug 19, 2003 this sequence version replaced BC002576.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 4 Row: b Column: 24
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 11342665.
FEATURES Location/Qualifiers
source 1..3065
/db_xref="H-InvDB:HIT000031004"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:2313 IMAGE:3161383"
/tissue_type="Brain, neuroblastoma"
/clone_lib="NIH_MGC_19"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..3065
/gene="MMP2"
/gene_synonym="MMP-II"
/gene_synonym="MONA"
/gene_synonym="TBE-1"
/db_xref="GeneID:4313"
/db_xref="HGNC:HGNC:7166"
/db_xref="MIM:120360"
CDS 267..2249
/gene="MMP2"
/gene_synonym="MMP-II"
/gene_synonym="MONA"
/gene_synonym="TBE-1"
/codon_start=1
/product="matrix metallopeptidase 2 (gelatinase A, 72kDa
gelatinase, 72kDa type IV collagenase)"
/protein_id="AAH02576.1"
/db_xref="GeneID:4313"
/db_xref="HGNC:HGNC:7166"
/db_xref="MIM:120360"
/translation="MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPK
TDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRC
GNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFS
RIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEG
QVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPH
EALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPE
TAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPD
QGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPD
IDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLL
VATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQ
RVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQ
GGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC"
BASE COUNT 678 a 927 c 834 g 626 t
ORIGIN
1 ctcaggcggt ggctggaggc tgcgcatctg gggctttaaa catacaaagg gattgccagg
61 acctgcggcg gcggcggcgg cggcgggggc tggggcgcgg gggccggacc atgagccgct
121 gagccgggca aaccccaggc caccgagcca gcggaccctc ggagcgcagc cctgcgccgc
181 ggagcaggct ccaaccaggc ggcgacgcgg ccacacgcac cgagccagcg acccccgggc
241 gacgcgcggg gccagggagc gctacgatgg aggcgctaat ggcccggggc gcgctcacgg
301 gtcccctgag ggcgctctgt ctcctgggct gcctgctgag ccacgccgcc gccgcgccgt
361 cgcccatcat caagttcccc ggcgatgtcg cccccaaaac ggacaaagag ttggcagtgc
421 aatacctgaa caccttctat ggctgcccca aggagagctg caacctgttt gtgctgaagg
481 acacactaaa gaagatgcag aagttctttg gactgcccca gacaggtgat cttgaccaga
541 ataccatcga gaccatgcgg aagccacgct gcggcaaccc agatgtggcc aactacaact
601 tcttccctcg caagcccaag tgggacaaga accagatcac atacaggatc attggctaca
661 cacctgatct ggacccagag acagtggatg atgcctttgc tcgtgccttc caagtctgga
721 gcgatgtgac cccactgcgg ttttctcgaa tccatgatgg agaggcagac atcatgatca
781 actttggccg ctgggagcat ggcgatggat acccctttga cggtaaggac ggactcctgg
841 ctcatgcctt cgccccaggc actggtgttg ggggagactc ccattttgat gacgatgagc
901 tatggacctt gggagaaggc caagtggtcc gtgtgaagta tggcaacgcc gatggggagt
961 actgcaagtt ccccttcttg ttcaatggca aggagtacaa cagctgcact gataccggcc
1021 gcagcgatgg cttcctctgg tgctccacca cctacaactt tgagaaggat ggcaagtacg
1081 gcttctgtcc ccatgaagcc ctgttcacca tgggcggcaa cgctgaagga cagccctgca
1141 agtttccatt ccgcttccag ggcacatcct atgacagctg caccactgag ggccgcacgg
1201 atggctaccg ctggtgcggc accactgagg actacgaccg cgacaagaag tatggcttct
1261 gccctgagac cgccatgtcc actgttggtg ggaactcaga aggtgccccc tgtgtcttcc
1321 ccttcacttt cctgggcaac aaatatgaga gctgcaccag cgccggccgc agtgacggaa
1381 agatgtggtg tgcgaccaca gccaactacg atgacgaccg caagtggggc ttctgccctg
1441 accaagggta cagcctgttc ctcgtggcag cccacgagtt tggccacgcc atggggctgg
1501 agcactccca agaccctggg gccctgatgg cacccattta cacctacacc aagaacttcc
1561 gtctgtccca ggatgacatc aagggcattc aggagctcta tggggcctct cctgacattg
1621 accttggcac cggccccacc cccacactgg gccctgtcac tcctgagatc tgcaaacagg
1681 acattgtatt tgatggcatc gctcagatcc gtggtgagat cttcttcttc aaggaccggt
1741 tcatttggcg gactgtgacg ccacgtgaca agcccatggg gcccctgctg gtggccacat
1801 tctggcctga gctcccggaa aagattgatg cggtatacga ggccccacag gaggagaagg
1861 ctgtgttctt tgcagggaat gaatactgga tctactcagc cagcaccctg gagcgagggt
1921 accccaagcc actgaccagc ctgggactgc cccctgatgt ccagcgagtg gatgccgcct
1981 ttaactggag caaaaacaag aagacataca tctttgctgg agacaaattc tggagataca
2041 atgaggtgaa gaagaaaatg gatcctggct ttcccaagct catcgcagat gcctggaatg
2101 ccatccccga taacctggat gccgtcgtgg acctgcaggg cggcggtcac agctacttct
2161 tcaagggtgc ctattacctg aagctggaga accaaagtct gaagagcgtg aagtttggaa
2221 gcatcaaatc cgactggcta ggctgctgag ctggccctgg ctcccacagg cccttcctct
2281 ccactgcctt cgatacaccg ggcctggaga actagagaag gacccggagg ggcctggcag
2341 ccgtgccttc agctctacag ctaatcagca ttctcactcc tacctggtaa tttaagattc
2401 cagagagtgg ctcctcccgg tgcccaagaa tagatgctga ctgtactcct cccaggcgcc
2461 ccttccccct ccaatcccac caaccctcag agccacccct aaagagatcc tttgatattt
2521 tcaacgcagc cctgctttgg gctgccctgg tgctgccaca cttcaggctc ttctcctttc
2581 acaaccttct gtggctcaca gaacccttgg agccaatgga gactgtctca agagggcact
2641 ggtggcccga cagcctggca cagggcagtg ggacagggca tggccaggtg gccactccag
2701 acccctggct tttcactgct ggctgcctta gaacctttct tacattagca gtttgctttg
2761 tatgcacttt gtttttttct ttgggtcttg tttttttttt ccacttagaa attgcatttc
2821 ctgacagaag gactcaggtt gtctgaagtc actgcacagt gcatctcagc ccacatagtg
2881 atggttcccc tgttcactct acttagcatg tccctaccga gtctcttctc cactggatgg
2941 aggaaaacca agccgtggct tcccgctcag ccctccctgc ccctcccttc aaccattccc
3001 catgggaaat gtcaacaagt atgaataaag acacctactg agtgaaaaaa aaaaaaaaaa
3061 aaaaa
//