LOCUS BC002575 3237 bp mRNA linear HUM 04-NOV-2003
DEFINITION Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 37, mRNA (cDNA
clone IMAGE:3161568), partial cds.
ACCESSION BC002575
VERSION BC002575.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3237)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3237)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (05-FEB-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Oct 28, 2003 this sequence version replaced BC002575.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 4 Row: b Column: 22.
FEATURES Location/Qualifiers
source 1..3237
/db_xref="H-InvDB:HIT000086141"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:3161568"
/tissue_type="Brain, neuroblastoma"
/clone_lib="NIH_MGC_19"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene <1..3237
/gene="DHX37"
/gene_synonym="DDX37"
/gene_synonym="KIAA1517"
/gene_synonym="MGC2695"
/gene_synonym="MGC4322"
/gene_synonym="MGC46245"
/db_xref="GeneID:57647"
CDS <1..2956
/gene="DHX37"
/gene_synonym="DDX37"
/gene_synonym="KIAA1517"
/gene_synonym="MGC2695"
/gene_synonym="MGC4322"
/gene_synonym="MGC46245"
/codon_start=2
/product="DHX37 protein"
/protein_id="AAH02575.2"
/db_xref="GeneID:57647"
/translation="REESELDEDPAAEPAEAGVGTTVAPLPPAPAPSSQPVPAGMTVP
PPPAAAPPLPRALAKPAVFIPVNRSPEMQEERLKLPILSEEQVIMEAVAEHPIVIVCG
ETGSGKTTQVPQFLYEAGFSSEDSIIGVTEPRRVAAVAMSQRVAKEMNLSQRVVSYQI
RYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRI
VTLRAKRNLPLKLLIMSATLRVEDFTQNPRLFAKPPPVIKVESRQFPVTVHFNKRTPL
EDYSGECFRKVCKIHRMLPAGGILVFLTGQAEVHALCRRLRKAFPPSRARPQEKDDDQ
KDSVEEMRKFKKSRARAKKARAEVLPQINLDHYSVLPAGEGDEDREAEVDEEEGALDS
DLDLDLGDGGQDGGEQPDASLPLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVA
ETSLTIPGIKYVVDCGKVKKRYYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCY
RLYSSAVFGDFEQFPPPEITRRPVEDLILQMKALNVEKVINFPFPTPPSVEALLAAEE
LLIALGALQPPQKAERVKQLQENRLSCPITALGRTMATFPVAPRYAKMLALSRQHGCL
PYAITIVASMTVRELFEELDRPAASDEELTRLKSKRARVAQMKRTWAGQGASLKLGDL
MVLLGAVGACEYAGCTPQFCEANGLRYKAMMEIRRLRGQLTTAVNAVCPEAELFVDPK
MQPPTESQVTYLRQIVTAGLGDHLARRVQSEEMLEDKWRNAYKTPLLDDPVFIHPSSV
LFKELPEFVVYQEIVETTKMYMKGVSSVEVQWIPALLPSYCQFDKPLEEPAPTYCPER
GRVLCHRASVFYRVGWPLPAIEVDFPEGIDRYKHFARFLLEGQVFRKLASYQSCLLSS
PGTMLKTWARLQPRTESLLRALVAEKADCHEALLAAWKKNPKYLLAEYCEWLPQAMHP
DIEKAWPPTTVH"
misc_feature 293..715
/gene="DHX37"
/gene_synonym="DDX37"
/gene_synonym="KIAA1517"
/gene_synonym="MGC2695"
/gene_synonym="MGC4322"
/gene_synonym="MGC46245"
/note="DEXHc; Region: DEXH-box helicases. A diverse family
of proteins involved in ATP-dependent DNA or RNA
unwinding, needed in a variety of cellular processes. The
name derives from the sequence of the Walker B motif
(motif II). This domain contains the ATP-binding region"
/db_xref="CDD:cd00269"
misc_feature 1280..1504
/gene="DHX37"
/gene_synonym="DDX37"
/gene_synonym="KIAA1517"
/gene_synonym="MGC2695"
/gene_synonym="MGC4322"
/gene_synonym="MGC46245"
/note="HELICc; Region: helicase superfamily c-terminal
domain"
/db_xref="CDD:smart00490"
misc_feature 1784..2065
/gene="DHX37"
/gene_synonym="DDX37"
/gene_synonym="KIAA1517"
/gene_synonym="MGC2695"
/gene_synonym="MGC4322"
/gene_synonym="MGC46245"
/note="HA2; Region: Helicase associated domain (HA2). This
presumed domain is about 90 amino acid residues in length.
It is found is a diverse set of RNA helicases. Its
function is unknown, however it seems likely to be
involved in nucleic acid binding"
/db_xref="CDD:pfam04408"
BASE COUNT 685 a 971 c 999 g 582 t
ORIGIN
1 gagagaggag tcggagctgg acgaggaccc agctgctgag ccggctgagg ctggtgtggg
61 gaccaccgtg gcacctctgc cgccagctcc agcacccagc agtcagcccg tgccggctgg
121 gatgactgtt cctcctcctc cagctgcagc cccaccactg cccagggccc tggctaagcc
181 cgccgtcttc atccccgtga accgctcccc ggaaatgcag gaggaacggc tgaagctccc
241 aattctctcc gaagaacaag taatcatgga ggctgtggcc gagcacccca tcgtcatcgt
301 gtgtggtgag accggcagcg ggaagaccac acaggtgcct cagtttctct atgaagcagg
361 cttcagcagt gaagacagca tcatcggtgt cacggagccc cgccgagtgg ccgccgtggc
421 catgtcccag cgagtggcca aggagatgaa tctgtcccag cgggtcgtct cctaccagat
481 ccggtatgaa ggaaacgtga cagaggagac cagaatcaag ttcatgacgg atggtgtgct
541 gcttaaagaa atccagaagg acttcctgct gctgcggtac aaggtggtga tcatcgacga
601 ggcccacgag aggagcgtgt acacggacat cctcatcggc ctcctgtccc gcattgtgac
661 tctccgggct aagaggaacc tgccactcaa gctgctcatc atgtcggcca cgctgcgggt
721 ggaggacttc acccagaacc cacggctctt cgccaagccg ccgccggtca tcaaggtgga
781 atccaggcag ttcccagtga ctgtgcattt caacaagcgg acaccgctgg aagactacag
841 tggcgagtgc ttccggaagg tctgcaagat ccaccggatg ctgcccgcag gtggcatcct
901 ggtgttcctg acggggcagg ctgaggtgca tgcgctgtgc cgcaggctca ggaaggcttt
961 cccaccctcc agagcccggc cacaagaaaa ggacgacgat cagaaagact cggtggagga
1021 aatgcggaag tttaagaagt caagggccag ggccaagaag gcgcgggctg aggtgctgcc
1081 ccagatcaac ttggatcatt actcggtgtt accggcaggc gaaggcgatg aggacaggga
1141 ggcagaagtg gatgaggaag agggggccct ggactccgac ctcgatctgg acctggggga
1201 tggcgggcaa gatggaggtg agcagccgga tgcctccctc ccgctccacg tgctcccgct
1261 gtactctctg ctggccccag agaagcaagc acaggtcttt aagcctccac cggaggggac
1321 tcggttgtgt gttgtggcca ccaatgtggc cgagacgtcg cttaccatcc ctggcatcaa
1381 gtacgtggtg gactgtggga aggtcaagaa acgctactac gaccgcgtca ctggcgtatc
1441 ctccttccgt gtcacctggg tctcccaggc atcagctgac cagcgagcgg gcagagcagg
1501 acggacggag cccggccact gctacaggct gtattcatct gcggtttttg gtgacttcga
1561 gcagtttcct cctccagaaa tcacccggag gcctgttgaa gacttaatcc ttcaaatgaa
1621 ggcgctcaac gttgaaaagg tcatcaactt ccccttcccg acgcccccct ccgtggaagc
1681 ccttcttgcc gccgaggagc tgttgatcgc actgggtgcc ctgcaaccgc cccagaaagc
1741 agaaagggtg aagcaactgc aggagaaccg gctgagctgc cccatcactg cgctgggccg
1801 gacaatggcc acattccccg tggcaccccg ctacgctaag atgctggcac tgagccgaca
1861 acacggctgc ctgccctatg ccatcaccat cgtggccagc atgacggtgc gggagctgtt
1921 tgaggagctg gacagaccag cggccagtga cgaggagctc accaggctga agagcaagcg
1981 ggcccgggtg gcccagatga agaggacctg ggcagggcag ggggcttctc tgaagctcgg
2041 cgacctcatg gtgctgctgg gcgccgtggg agcctgtgaa tatgccggct gcacacccca
2101 gttttgcgaa gccaacgggc tgcggtacaa agccatgatg gagatccggc gcctgcgggg
2161 ccagctgacc accgcagtca atgccgtgtg ccccgaggct gagctcttcg tggatcccaa
2221 gatgcagccg cccaccgaga gccaggtgac ctacctgcga cagatcgtga cggcgggcct
2281 gggggaccac ttggcccgca gggtccagag cgaggagatg ctggaggaca agtggaggaa
2341 cgcctacaag acccctctcc tcgacgaccc tgtcttcatc caccccagct ccgtcctttt
2401 caaagagctc cccgagtttg tggtctacca ggaaatcgtg gagaccacta agatgtacat
2461 gaaaggcgtc tctagcgtgg aggtccagtg gatcccggcc ctgctgccct cttactgcca
2521 gtttgacaag cccctggagg aaccagcccc tacatactgc cccgagcggg ggcgggtgct
2581 gtgtcaccgg gccagcgtgt tctatcgcgt gggctggccg ctccccgcca tcgaggtgga
2641 ttttccagag gggattgacc gctacaagca ctttgcccgg ttcctgctgg aagggcaggt
2701 cttccgcaag ctggcctcat accagagctg tctgctgtcc agccccggca ccatgctgaa
2761 gacgtgggcc aggctgcagc cccgtacgga gagccttctg cgagccctgg ttgcagagaa
2821 ggctgactgc catgaagcct tgctggctgc ttggaagaaa aaccccaaat acctgctggc
2881 tgagtactgt gagtggcttc cacaggccat gcaccccgat atcgagaaag cctggccccc
2941 caccactgtc cactgaccag aaacctggct gcagggccga ggactggttt ggggactgga
3001 gggctggcag cagcctgtca ccgtgcgacc gtgaccacct ggcatgggct tcgtggcctg
3061 ctctcaggaa gtgggtcaag ccctgggaac cctcatccat gagagctcga tcccgtatga
3121 agggtgctgc cgcccgtgcc atctggcccg ggggtgactt tttgaactgt ttattatatg
3181 gtggatgatg atttcatctc acgtgctgga aaaaaaaaaa aaaaaaaaaa aaaaaaa
//